Find trials
Consejos para buscar

A Study to Better Understand the Mechanisms that Can Cause Knee Osteoarthritis (OA) following Anterior Cruciate Ligament (ACL) Rupture and ACL Reconstruction (ACLR)

Overview

Información sobre este estudio

The purpose of this study is to better understand the mechanisms that can cause knee osteoarthritis (OA) following anterior cruciate ligament (ACL) rupture and ACL reconstruction (ACLR). Those who suffer an ACL injury have a dramatically increased risk of developing early onset knee OA compared to those who do not injure their ACL. While research has established a causal link between ACL injury and OA, the mechanism behind it is still unclear.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Patients who have undergone ACLR 
    • The first group will comprise of patients who have undergone ACLR within the past 1-3 years and have been cleared to return to sport. 
      • Target age range of 14 to 35 
    • The second group will comprise of patients who are beginning to show signs of knee OA, which may include clinical signs of OA (joint stiffness and/or pain), KOOS scores, or radiographic signs of OA (joint space narrowing).
      • The sports orthopedics and physical therapy clinics at OSU Wexner Medical Center for subject recruitment.
      • There will not be a strict age limit. However, due to the nature of the progression of OA after an ACLR, we expect that this group will be between 24-50 years of age.

Exclusion Criteria:

  • Any concomitant grade III sprain (full tear) of ligamentous structures in the knee aside from the ACL, fractures, or injuries in the leg that require surgery.
  • Acute chondral defects will also be exclusionary.
    • Meniscal injuries will not be exclusionary, as they are frequently associated with ACL tears.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Timothy Hewett, Ph.D.

Cerrado para la inscripción

Contact information:

Timothy Hewett Ph.D.

Hewett.Timothy@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

.
CLS-20423884

Mayo Clinic Footer