Ensayos clínicos

Inclusion Criteria:

• Patients must be between the ages of 18 and 65, who have undergone TAC with IPAA for any indication (i.e., ulcerative colitis, indeterminate colitis, FAP). 
• All patients will have had closure of ileostomy, with reinstitution of fecal stream through the ileal pouch, at least 1 year prior to enrollment in the study.
• Fifteen patients with and 15 without symptoms suggestive of a defecatory disorder based on Rome IV questionnaire for functional defecation disorders will be enrolled in this study (considered symptomatic for a response of at least ‘often’ to any of the following questions:
  • Straining during bowel movements;
  • Feeling of incomplete evacuation; 
  • Sensation of blocked stools;
  • Manual maneuvers to facilitate defecation;
  • Difficulty relaxing to allow defecation for at least the previous 6 months. 
• Subjects will have their vital signs checked and documented at their screenining visits:
  • Height;
  • Weight;
  • Temperature;
  • Blood pressure.
• Subjects will also undergo a physical exam which will include an abdominal exam and a rectal exam. The Rome IV and SIBDQ questionnaires will be asked at screening.

Exclusion Criteria:

• Female patients who are pregnant.
• Patients unable to give informed consent.
• Patients with significant cardiovascular, respiratory, neurological, psychiatric, or endocrine disease will be excluded from the study.