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Validation of Cognitive Tests in Elderly Cirrhotic Patients

Overview

Información sobre este estudio

The purpose of this study is to define the prevalence and impact of cognitive impairment and their impact on HRQOL in elderly patients with cirrhosis compared to elderly patients without cirrhosis.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria

Group 1: Elderly Controls

  • Age Between 65 and 95 with Preserved activities of daily living
  • Able to give consent for study
  • MME_>25
  • Without Evidence of MCI and/or Chronic Liver Disease/cirrhosis

Group 2: Elderly Cirrhosis

  • Age Between 65and 95 years
  • Able to give consent
  • Clinically or biopsy proven cirrhosis

Exclusion Criteria:

Group 1: Elderly Controls

  • Unable to give informed consent
  • Alcohol/illicit drug abuse within 3 months
  • History of mental illness disorders (bipolar, schizophrenia, uncontrolled depression BDI>20, seizure disorder), cerebrovascular disease (stroke), progressive neurological diseases (severe neuropathy, Parkinson’s, Multiple sclerosis etc).  Serious liver (cirrhosis, hepatitis of any kind, fatty liver without >3 ULN AST and ALT ok), kidney (CKD > stage II), heart (any uncontrolled CAD, CHF, AFib and other serious arrhythmias), respiratory (COPD, IPF), endocrine (DM if last hemoglobin Aic >7.5), or metabolic diseases (osteoporosis is ok)
  • Current therapy with Galantamine and Aricept or other therapies directed for dementia
  • Use of anti-psychotics and any anti-seizure medications

Group 2: Elderly Cirrhosis

  • Not able to give consent
  • Alcohol and Illicit drug use within the last 3 months of study
  • TIPS within the last 3 months
  • Focal neurological deficits noted in the medical chart
  • Use of any anti-psychotics and anti-seizure medications
  • History of mental illness disorders (bipolar, schizophrenia, uncontrolled depression BDI>20, seizure disorder), cerebrovascular disease (stroke), progressive neurological diseases (severe neuropathy, Parkinson’s, Multiple sclerosis etc).  Serious kidney (CKD > stage II), heart (any uncontrolled CAD, CHF, AFib and other serious arrhythmias), respiratory (COPD, IPF), endocrine (DM if last hemoglobin Aic >7.5), or metabolic diseases (osteoporosis is ok).

 

 

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Hugo Vargas, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20408131

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