Ensayos clínicos

Inclusion Criteria:

Aim 1 and 2

HCC cases (HIV infected, n=100) and controls (HIV uninfected, n=100): 

1. >18yrs
2. Confirmed to have HCC diagnosed by ultrasound and CT scan
3. On stable antiretroviral therapy (ART) for at least 6 months

HIV-infected HCC negative controls (n=100):

1. >18yrs
2. On ART for at least 6 months.

Aim 3

1. Known HIV statu 
2. >18 years of age 
3. TE score >9.3 Kpa 
4. On ART for at least 6 months   
5. Intending to stay in the Jos or Lagos area for at least 24 months 
6. Not pregnant.

Exclusion Criteria:

Aim 1 and 2

HCC cases (HIV infected, n=100) and controls (HIV uninfected, n=100): 

1. Other known primary or secondary malignancy; b) history of malignancy within the past 5 years.

HIV-infected HCC negative controls (n=100):

1. Clinical and/or radiologic evidence of HCC, other liver diseases such as autoimmune hepatitis, cholestatic liver diseases, Wilson Disease, hemochromatosis; or other primary or secondary malignancy 
2. >21 alcoholic drinks per week
3. Adults unable to consent
4. Individuals who are not yet adults (infants, children, teenagers)
5. Pregnant women and Prisoners

Aim 3

1. Have clinical and/or radiologic evidence of HCC, other liver diseases such as autoimmune hepatitis, cholestatic liver diseases, Wilson Disease, hemochromatosis; or other primary or secondary malignancy.