Ensayos clínicos

Inclusion Criteria:

• 3 groups:

  • Group 1 will include 8 patients with a DSM-5 diagnosis of anorexia nervosa;
  • Group 2 will include 8 healthy normal weight volunteers (BMI 20-25); and
  • Group 3 will include 8 patients with class I-II obesity (BMI 30-40).
• Age > 18 and ≤ 50 years.
• Stable weight for 3 months prior to study entry.
• Able to provide written informed consent prior to any study procedures, and be willing and able to comply with study procedures.

Exclusion Criteria:

• Any contraindications to MRI.
• Claustrophobia.
• Diabetes.
• Unstable coronary artery disease.
• Heart failure.
• Cardiac arrhythmia.
• Cardiac valvular disease.
• Obstructive or interstitial lung disease.
• Pregnancy.
• Previous gastric surgery.
• Gastroparesis.
• Congenital abnormalities of the GI tract.
• Currently on or prescribed a medication or over the counter supplement known to affect weight or satiety within 3 months of study entry.
• A positive score on the AUDIT-C questionnaire as judged by an investigator.
• Patient has a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder study adherence.