Ensayos clínicos

Inclusion Criteria:

Eligible patients will be offered enrollment if the time interval between initial diagnosis and surgery allows for performance of the PEM studies with both F18 FDG and F-18 FES, and they meet the following criteria:

• Postmenopausal women, as defined by
  • Lack of menstrual periods for ≥ 12 months
  • For women with prior hysterectomy and age < 60, a serum FSH level within the postmenopausal range
• Histologic proof of invasive breast carcinoma that is ER positive per ASCO/CAP guidelines (staining in ≥ 1% of cells by immunohistochemistry)
• Extent of disease confirmed, or to be confirmed, on a clinical contrast-enhanced breast MRI examination
• Minimum size criteria for index cancer of 10 mm as measured on mammogram, ultrasound, or MRI.
• Planned surgical excision of the breast cancer at Mayo Clinic, Rochester

Exclusion Criteria:

Patients are excluded if they meet any of the following criteria:

• Premenopausal
• Unable to undergo PEM scanning (weight limit of 300 lbs. on PEM system or inability to lie prone for 30 minutes)
• Total serum bilirubin > 1.5 x upper limit of normal (abnormal hepatic metabolism may interfere with FES hepatic excretion),
• Serum creatinine > 1.5 x upper limit of normal
• Patients who have received, are currently receiving, or planning to receive neoadjuvant systemic therapy prior to surgical excision
• Patients who will undergo core needle biopsy of the breast or axilla between the breast MRI and investigational PEM studies. NOTE: Axillary ultrasound with or without fine needle aspiration of an axillary mass or lymph node is allowed.
• Patients with breast implants?