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Thyroid Autoimmune Dysfunction Due to Immune Checkpoint Inhibitors

Overview

Información sobre este estudio

The primary objective is to characterize the immune cell phenotypes in thyroid fine needle aspirates (FNA) and the peripheral blood of patients with ICI-induced thyroid dysfunction using flow cytometry. Control patients will be those with thyroid nodules as well as autoimmune thyroid disease, with and without exposure to ICI.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Provide voluntary and written informed consent to be included in the study (for those who are not fluent in English, we will consult an interpreter who can go over the consent with patient).
  • ICI cohort patients: About to start ICI therapy or are currently on ICI therapy (patients who have started therapy, must have baseline thyroid function test values available for review) for treatment of their malignancy.
  • Non-ICI cohort patients: Referred to thyroid clinic for further evaluation of thyroid nodules, autoimmune thyroid disease and/or diagnosis of primary thyroid malignancy.
  • Must be willing to undergo blood collections as outlined in the protocol.
  • Patients who are already on thyroid replacement therapy are eligible only if they have had a ≥50% increase or decrease in dose in their thyroid replacement therapy since starting an ICI agent.

Exclusion Criteria:

  • Pregnant
  • Prisoners
  • Not willing to voluntarily consent or if withdraw consent at any time during the course or of the study.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Mabel Ryder, M.D.

Cerrado para la inscripción

Contact information:

Anupam Kotwal M.B.B.S.

(507) 266-0500

Kotwal.Anupam@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20396294

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