Mechanical Ventilation Guided By Transpulmonary and Airway Driving Pressures

Overview

Información sobre este estudio

The purpose of this study is to test the correspondence between Airway Driving Pressure (DPAW; defined as plateau pressure minus positive end-expiratory pressure) and transpulmonary driving pressure (DPTP)—the quotient of tidal volume and lung compliance (CL), in response to intra-abdominal hypertension and changes in positive end-expiratory pressure during laparoscopic and robotic surgical interventions requiring intra-abdominal insufflation.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Patients requiring mechanical ventilation for abdominal laparoscopic and robotic surgeries.
  • Patients who are passively ventilated (no respiratory efforts) as a result of the sedation plan determined entirely by the primary anesthesia team --research team will not influence or participate on the sedation protocol plan or implementation.
  • Patients who are clinically stable and able to tolerate the changes in position that are routinely conducted as part of the standard of care in the operative room.
  • Patient/responsible family member signing the informed consent must speak English.

Exclusion Criteria:

  • Patients with open abdomen prior to surgical procedures.
  • Body mass index (BMI) greater than 35.
  • Patients with clinically evident spontaneous breathing efforts (ventilator wave forms) during surgical procedure.
  • Patients with clinical suspicion of elevated intra-cranial pressure (requiring head elevation).
  • Contraindication to body position change, as dictated by surgery-specific protocol.
  • Unstable cardio-respiratory insufficiency.
  • Age less than 18 years.
  • Cuff leak in endotracheal / tracheostomy tube.
  • Patient/responsible family member unable to understand the informed consent in English.
  • Patient with contraindication for nasogastric tube placement:
    • Severe midface trauma
    • Recent nasal surgery
    • Coagulation abnormality
    • Esophageal varices or stricture
    • Recent banding of esophageal varices
    • Alkaline ingestion

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Richard Oeckler, M.D., Ph.D.

Cerrado para la inscripción

Contact information:

Linda Weise R.R.T., L.R.T.

(507) 293-2535

Weise.Linda@mayo.edu

More information

Publicaciones

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CLS-20359111

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