Ensayos clínicos

Inclusion Criteria:

• Age ≥ 18 years
• For iSGS:
  • Endoscopic confirmation of airway narrowing at or above the cricoid and at or below the larynx
  • Respiratory symptoms, including stridor or dyspnea at rest or with exertion
• For asthma:
  • Asthma documented by a MC pulmonologist on the basis of compatible symptoms with evidence of fixed or inducible/reversible airways obstruction with or without elevated exhaled nitric oxide (eNO)
  • Evidence of active airflow obstruction based either on a reduction in the patient’s peak expiratory flow (PEF) <80% of personal best or irreversible obstruction on PF testing
• For healthy volunteers:
  • Absence of chronic cardiopulmonary conditions and respiratory symptoms

Exclusion Criteria:

• Smoking
• Restrictive lung disease
• Diseases known to cause neuromuscular weakness: amyotrophic lateral sclerosis, phrenic nerve injury, frailty
• MVV<30 times the one-second forced expiratory volume (FEV1) in asthma or healthy controls groups