Ensayos clínicos

Inclusion Criteria:

• IMWG criteria for the diagnosis of either MGUS or MM5.
• Presence of measurable disease defined by an M-spike of >1 g/dL and/or involved serum free immunoglobulin light chain >10 mg/dL.

For MGUS cohort only:

• At least 5 to <10% cPCs in the prior BM aspirate.
• Not received any plasma cell directed therapy.

For MM cohort

• At least >10% cPCs in recent BM aspirate.
• Newly diagnosed MM without receiving any plasma cell directed therapy OR Relapsed MM without having received salvage chemotherapy.

Exclusion Criteria:

For both MGUS and MM cohorts:

• Unable to provide consent.
• ECOG PS >1.
• Hemoglobin < 8g/dL.
• GFR <50 ml/min.
• Women who are pregnant.
• Abnormal liver function tests.
• Abnormal bleeding history or coagulation profile (INR >1.5).
• Prior history of adverse events with conscious sedation.