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The Use of Human Mesenchymal Stem Cell Technology for Treatment of Mandibular Osteoradionecrosis

Overview

Información sobre este estudio

We are currently working on a research project to investigate the use of stem cells to regenerate bone in the jaw that is unhealthy as a result of osteoradionecrosis (ORN). Stem cells have the capability to develop into bone, cartilage, fat, skin or blood vessels, and are thought to be involved in the healing process. Using your discarded jawbone (if this is being removed) and/or fat, we can generate stem cells and see if they can heal the bone in the laboratory setting. If this proves successful, we may be able to use this technology in patients to avoid extensive surgery.

In order to test this idea, the segment of your jawbone (if this is being removed) and/or fat which is routinely discarded as waste will be sent for testing. Our goal is generate stem cells for replacement of bone from patients suffering from this disease.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  1. Manidbular bone, as well as fat (from the neck and donor site) , will be harvested in any patient undergoing manidbular reconstruction for osteoradionecrosis

    OR

  2. Fat (from the neck and donor site) will be harvested from any patient undergoing tumor ablation and subsequent reconstruction with a prior history of head and neck irradiation

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Jeffrey Janus, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20320104

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