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Neuromyelitis Optica Clinical Consortium (NMOCC) Clinical Database Development for Neuromyelitis Optica Spectrum Disorders

Overview

Información sobre este estudio

The primary objective is of this protocol to create a database of NMO patient information that can be queried to address specific scientific questions.  The first series of questions will focus on the clinical characteristics and course of the disease.  For example, sex ratio, ethnicity, and age of onset will be described for NMOSD as a whole and amongst the different diagnostic subcategories.  A main question of whether NMO-IgG seropositive patients differ with respect to disease activity compared with seronegative patients and exploratory multivariable analyses of the natural history will be conducted

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

The inclusion criteria for this study are the following:

  1. The patient must satisfy diagnostic criteria for at least one of the following diseases:
    1. Neuromyelitis optica spectrum disorders—Diagnostic criteria include history or evidence of optic neuritis and longitudinally extensive transverse myelitis without symptomatic involvement of the brain by history or MRI.
      1. NMO seropositive patients are those who have a circulating antibody, NMO-IgG, against aquaporin-4.
      2. NMO seronegative patients are those who likely have NMO but do not test positive for the NMO-IgG
      3. Any clinical syndrome associated with positive NMO-IgG
    2. Bilateral optic neuritis—Diagnostic criteria include history or evidence of optic neuritis in both eyes without symptomatic involvement of the brain by history.
    3. Longitudinally extensive transverse myelitis—Diagnostic criteria include history or evidence of longitudinally extensive inflammation across at least three continuous vertebral lengths of the spinal cord without symptomatic involvement of the brain by history or MRI.
    4. Recurrent transverse myelitis—Diagnostic criteria include history or evidence of inflammation in the spinal cord that recurred at least 3 months apart with evidence of remission in between events.
    5. Monophasic transverse myelitis—Diagnostic criteria include history of evidence of inflammation in one focal area of the spinal cord without recurrence or symptomatic involvement of the brain by history or MRI.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Dean Wingerchuk, M.D.

Cerrado; inscripción por invitación

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"Close"
El estudio no está abierto para todos los que cumplen con los criterios de elegibilidad, sino solamente para las personas que el equipo del estudio ha invitado a participar.

Contact information:

Anne Allen

(480) 342-6054

Allen.Anne@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20316795

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