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Evaluating Childhood Cardiovascular Health Outcomes in NEPTUNE and CureGN

Overview

Información sobre este estudio

The purpose of this research study is to learn more about the risks to heart health in children and young adults with nephrotic syndrome. Nephrotic syndrome is a rare kidney condition that can affect children. They may be more likely to develop heart disease, high blood pressure and high cholesterol. We hope that the results of this study will help us to learn which tests should be used to determine which patients are most at risk for developing these illnesses.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria

  1. Participants age 6-21 years enrolled in either NEPTUNE or CureGN(The lower age limit was chosen based on ability to cooperate with study-related procedures.)

  2. Participants with a diagnosis of FSGS

  3. Participants with a diagnosis of MCNS with active disease defined as follows:

            a) steroid dependent- relapse during corticosteroid therapy or within 2 weeks of discontinuing corticosteroids

            b) frequently relapsing- ≥2 relapses in 6 months or ≥4 relapses in 12 months or

            c) steroid resistant - failure to induce remission with corticosteroids within 8 weeks

     4.   Informed consent from the parent or guardian and assent from a minor of ≥ 7 years

   Exclusion Criteria

  1. Participants with a diagnosis of IgA nephropathy, membranous nephropathy or other glomerular disease that is not FSGS or MCNS

  2. Participants on dialysis or who have a kidney transplant

  3. Participants with major co-morbid conditions such as cardiac disease, pulmonary disease, neurologic disease, diabetes mellitus or a genetic syndrome

  4. Participants/guardians or participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Cheryl Tran, M.D.

Cerrado para la inscripción

Contact information:

Julia Byrne

(507)538-4665

Byrne.Julia@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20314740

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