Dissecting the Genetic Environment Contributions of Autoimmune Liver Disease

Overview

Información sobre este estudio

The overall objective of this proposal is to conduct a systematic approach to dissect both genetic underpinnings and non-genetic factors in the development of adult autoimmune liver diseases including autoimmune hepatitis (AIH), overlap AIH with Primary Biliary Cirrhosis (AIH-PBC), overlap AIH with Primary Sclerosing Cholangitis (AIH-PSC), and drug-induced autoimmune-like hepatitis (DIAIH).

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

AIH patients

  • Male and female patients ages ≥ 7 years old.
  • Diagnosis of probable AIH on the pretreatment score as defined by the International Autoimmune Hepatitis Group (IAIHG) revised criteria or
  • Diagnosis of probable AIH confirmed by the IAIHG Simplified Criteria for the Diagnosis of Autoimmune Hepatitis score

AIH-PBC Patients

  • Male and Female patients ages ≥ 7 years old.
  • Diagnosis of AIH-PBC overlap syndrome defined by the association of PBC and probable AIH either simultaneously or consecutively. 

AIH-PSC Patients

  • Male and Female patients ages ≥ 7 years old.

Diagnosis of AIH-PSC overlap syndrome defined by association of PSC and probable AIH

DIAIH Patients

  • Male and Female patients ages ≥ 7 years old.
  • Diagnosis of probable AIH on the pretreatment score as defined by the International Autoimmune Hepatitis Group (IAIHG) revised criteria or
  • Diagnosis of probable AIH confirmed by the IAIHG Simplified Criteria for the Diagnosis of Autoimmune Hepatitis score
  • Presence of a suspicion of drug etiology in triggering an AIH clinical picture.

Control Patients

  • Male and Female patients ages ≥ 7 years old.
  • No evidence, history or diagnosis of a chronic liver disease in medical history

Exclusion Criteria:

All AIH, overlap, DIAIH patients, and controls:

  • Prisoners and institutionalized individuals
  • Patients unable to provide consent

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Konstantinos Lazaridis, M.D.

Cerrado para la inscripción

More information

Publicaciones

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CLS-20314738

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