Ensayos clínicos

Inclusion Criteria: 

• All women will have a systolic blood pressure lower than 150 mmHg and a diastolic blood pressure lower than 95 mmHg
• Subjects will also be non-obese (BMI <30), non-smokers, non-diabetic, and if on blood pressure medication they will be monotherapy taking one type of anti-hypertensive medications. 
• Participants will be asked to stop taking the medication 5 half-lives before the study day (this will range from 2-5 days depending on the type of medication).

Group 1:

• Healthy, young women 
• Ages of 18 and 35 yrs 

Group 2:

• Postmenopausal women 
• 45-75 years of age with no history of menopausal hormone therapy 
  • Menopause will be defined as amenorrhea for >12 months excluding oophorectomy
  • Participants will be limited to women not taking hormone replacement therapy. 

Group 3:

• Postmenopausal women 
• 45-75 years of age on transdermal estrogen

Exclusion Criteria:

• Subjects taking any other medications, except for oral contraceptives or hormone therapy, will not be eligible
• Candidates will be considered ineligible if they have any acute or chronic disorders (other than mild hypertension, where systolic blood pressure is 140 to 150 mmHg)