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Study of von Willebrand Factor Multimers in Preeclampsia

Overview

Información sobre este estudio

This study is being done to look for early indicators in the blood and urine of hypertensive disorders of pregnancy. Specifically, this study will look for differences between gestational hypertension, preeclampsia, HELLP syndrome and normal pregnancy. The following indicators will be studied: specific activated clotting factors (proteins in the blood that help form clots); the enzyme that cleaves clotting factor aggregates (clots); and microparticles (small particles shed from cells) from blood vessel cells, platelets (part of the blood that forms clots) and in the urine. Gestational hypertension refers to a benign form of high blood pressure in pregnancy.  The results of this study might lead to the development of methods to identify this condition early, and new ways to treat it

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion criteria for preeclampsia:

  • Women in the third trimester of pregnancy with hypertension, proteinuria and edema.
  • Women with severe forms of preeclampsia who, in addition to the classical diad, develop:
  • Renal failure
  • Thrombocytopenia
  • Microangiopathic hemolytic anemia
  • Elevated liver enzymes
  • Neurological symptoms and signs, including convulsions
  • Epigastric pain
  • Retinal hemorrhage, exudates, papilledema
  • Pulmonary edema.  

Inclusion criteria for normal pregnancy:

  • Women in the third trimester of pregnancy without hypertension and proteinuria both during the pregnancy and in the early postpartum period. The presence of edema, but without hypertension and proteinuria, will be acceptable since edema develops in one third of otherwise normal pregnancies.  

Exclusion criteria for both groups:

  • Women with chronic diseases that predispose them to superimposed preeclampsia, such as:
  • Chronic renal failure
  • Diabetes mellitus
  • Pre-existing hypertension.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Vesna Garovic, M.D., Ph.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20314051

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