Ensayos clínicos

Inclusion Criteria

• Diagnosis of chronic obstructive pulmonary disease.
• Relatively stable airway obstruction with post FEV1 < 80% predicted normal and post FEV1/FVC <70%
• Male or female patients
• Age 40 years or older
• Smoking history of more than 10 pack years

Exclusion Criteria

• Significant disease other than COPD
• Clinically relevant abnormal lab values.
• History of asthma.
• Diagnosis of thyrotoxicosis
• Diagnosis of paroxysmal tachycardia
• History of myocardial infarction within 1 year of screening visit
• Unstable or life-threatening cardiac arrhythmia
• Hospitalization for heart failure within the past year
• Known active tuberculosis.
• Malignancy for which patient has undergone resection, radiation therapy or chemotherapy within last five years
• History of life-threatening pulmonary obstruction.
• History of cystic fibrosis
• Clinically evident bronchiectasis
• History of significant alcohol or drug abuse
• Thoracotomy with pulmonary resection
• Oral ß-adrenergics
• Oral corticosteroid medication at unstable doses
• Regular use of daytime oxygen therapy for more than one hour per day
• Pulmonary rehabilitation program in the six weeks prior to the screening visit
• Investigational drug within one month or six half lives (whichever is greater) prior to screening visit
• Known hypersensitivity to ß-adrenergic drugs, anticholinergics, BAC, EDTA
• Pregnant or nursing
• Women of childbearing potential not using a highly effective method of birth control
• Patients who are unable to comply with pulmonary medication restrictions