Find trials
Consejos para buscar

A Study of Alveolar-Capillary Recruitment as a Screening and Tracking Tool for Patients with Pulmonary Arterial Hypertension

Overview

Información sobre este estudio

The purpose of this study is to determine if non-invasive measurement of blood flow to the lungs and the movement of gas from the lungs to the blood stream at rest and in response to low to moderate intensity exercise can be used as an assessment tool to allow for earlier detection and monitoring of individuals with pulmonary-arterial hypertension, and the response to drug treatments.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria

  • Aim 1 PAH patients
    • Diagnosed as having Group 1 PAH
      • Idiopathic
      • Hereditary
      • Drug or toxin induced
      • Associated with connective tissue disease
    • Confirmation of PAH by right heart catheterization
    • Capacity to consent
  • Aim 2 PAH patients
    • Physician approves the prescription of ambrisentan
    • Equal number that have/do not have other medications for PAH

  • Healthy controls

    • Free of any cardiovascular or pulmonary disease
    • Not currently taking any medication
    • Age- and sex-matched to PAH subjects
    • Capacity to consent

Exclusion Criteria

  • Receiving subcutaneous prostanoids
    • Other medications (oral phosphodiesterase type 5 inhibitors, oral or inhaled prostanoids, calcium channel blockers, or l-arginine) allowed as long as subject has been taking them for at least 3 months prior to commencing study
  • Pregnant or considering trying to become pregnant during  enrollment in the study

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Bruce Johnson, Ph.D.

Cerrado para la inscripción

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Bruce Johnson, Ph.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

.
CLS-20310850

Mayo Clinic Footer