Ensayos clínicos

Inclusion Criteria:

• Rheumatoid Arthritis
  • Individuals must have at least one joint with definite clinical synovitis (swelling) that is not better explained by another disease.  Scores of categories A – D below will be added; a score of ≥ 6/10 is needed for inclusion in this study.
    • Joint Involvement
      • 1 large joint, 0 score
      • 2 – 10 large joints, 1 score
      • 1 – 3 small joints (with or without involvement of large joints), 2 score
      • 4 – 10 small joints (with or without involvement of large joints), 3 score
      • > 10 joints (at least 1 small joint), 5 score
    • Serology (at least one test result is needed)
      • Negative RF and Negative ACPA, 0 score
      • Low-positive RF or low-positive ACPA, 2 score
      • High-positive RF or high-positive ACPA, 3 score
    • Acute-phase reactants (at least one test result is needed)
      • Normal CRF and normal ESR, 0 score
      • Abnormal CRF or abnormal ESR, 1 score
    • Duration of symptoms
      • < 6 weeks, 0 score
      • ≥ 6 weeks, 1 score
• Psoriatic Arthritis
  • Individuals must have inflammatory articular disease (joint, spine, entheseal) with at least 3 of the following 5 points:
    • Evidence of psoriasis (one of a, b, c)
      • a. Current psoriasis: psoriatic skin or scalp disease currently present, as judged by a rheumatologist or a dermatologist
      • b. Personal history of psoriasis: a history of psoriasis obtained from patient or family physician, dermatologist, rheumatologist or other qualified health care professional
      • c. Family history of psoriasis: a history of psoriasis in a first or second degree relative by patient report
    • Psoriatic nail dystrophy
      • Typical psoriatic nail dystrophy, including onycholysis, pitting and hyperkeratosis observed on current physical exam
    • Negative test result for Rheumatoid Factor
      • Determined by any method except latex but preferably by ELISA or nephelometry, according to the local laboratory reference range
    • Dactylitis
      • Current (swelling of an entire digit)
      • History (a history of dactylitis recorded by a rheumatologist)
    • Radiological Evidence of juxta-articular new bone formation
      • Ill-defined ossification near joint margins - extending osteophyte formation - on plain X-ray films of hand or foot
  • Axial Spondyloarthritis
    • Individuals with all of the following 3 points:
      • Back pain
        • Lasting more than 3 months
        • Age of onset less than 45 years
      • One of a, b, c
        • a. Sacroiliitis on imaging (MRI or X-ray) plus one spondyloarthropathy feature listed below (in box c)
        • b. Positive testing for HLA-B27 plus two spondyloarthropathy features listed below (in box c)
        • c. Spondyloarthropathy features:
          • inflammatory back pain
          • Arthritis, enthesitis (heel)
          • Uveitis
          • Dactylitis
          • Psoriasis
          • Crohn's/colitis 
          • Good response to NSAIDS 
          • Family history for spondyloarthritis 
          • HLA-B27 
          • Elevated CRP 
          • Sacroiliitis on imaging
  • Peripheral Spondyloarthritis
    • Individuals that have been diagnosed with Arthritis, Enthesitis or Dactylitis AND one of criteria below:
      • At least one of the following - psoriasis, inflammatory bowel disease, preceding infection, HLA-B27, uveitis, or sacroiliitis on imaging (radiographs or MRI)
      • At least two of the following - arthritis, enthesitis, dactylitis, inflammatory back pain in the past, or a positive family history for spondyloarthritis

Exclusion Criteria:

• Individuals that are under the age of 18
• Prisoners
• Pregnant women
• Individuals that are functionally illiterate or unable to complete the questionnaires
• Non-English speaking subjects