Ensayos clínicos

Inclusion Criteria:

• Pediatric patients (aged 8-18 years) with chronic symptoms (>3 months) symptoms of  lightheadedness, syncope, headache, fatigue, weakness, sweating, nausea and heart palpitations, flushing, generalized puritis or dermatographism. 
• Consent obtained from a responsible guardian AND from subjects 8-17 years of age OR consent obtained from subjects 18 years of age.  

Exclusion Criteria:

• Previous diagnosis of a primary mast cell disorder (Systemic Mastocytosis or Monoclonal Mast Cell Activation Syndrome) or secondary mast cell activation disorder (IgE-mediated allergies).
• Concomitant therapy with anticholinergic, alpha-adrenergic antagonists, beta-adrenergic antagonists or other medications which could interfere with autonomic testing.  Patients may participate if the potentially interfering medication is held for five half-lives prior to the study