Ensayos clínicos

Inclusion Criteria

• Age 22 years or older
• Willing and able to give informed consent
• Clinical indication for nuclear stress test evaluation
• Chest pain syndrome
• Two or more coronary artery disease risk factors as defined by: 
  • Dyslipidemia: LDL >130 mm/dL or HDL <35 mm/dL or on treatment for dyslipidemia
  • Hypertension: blood pressure >140 mmHg systolic, >90 mmHg diastolic or on blood pressure altering treatment
  • Obesity: BMI>28
  • Current cigarette smoking
  • Diabetes: Type 1 or 2
  • Family history: coronary disease in a first or second degree relative

Exclusion Criteria

• Body Mass Index (BMI)<18.5 or BMI >40
• Known coronary disease as defined as:
  • Prior bypass surgery or coronary stenting
  • Q-wave infarction on a past EKG (>0.01 sec Q-wave duration in two adjacent leads)
  • Presence of pacemaker/defibrillator
  • Presence of artificial valve
  • Presence of obvious cyanotic or pre-diagnosed congenital heart defect and coarctation of the aorta
  • Presence of murmurs including valve lesions, ventricular septal defects, and AV fistualae
  • Presence of moderate or severe valve disease as defined by >1/6 heart murmur on physical diagnosis
  • Left Ventricular Assist Device (LVAD)
• Presence of scars on the site thorax areas
• Participation in trial within 30 days prior to collecting CADenceTM data except participation in registry studies
• Asthma with wheezing
• Inability to lie flat in the supine position
• Acute coronary syndrome with elevated cardiac biomarkers (TP>3x upper limit of normal (ULN) or CKMB>3x ULN)
• Heart Transplant
• Current cocaine use (within the past 24 hours, as reported by subject)
• Chronic Obstructive Pulmonary Disease (COPD)
• Contraindication to CT angiography
  • Renal failure with GFR<50 (angio risk)
  • Iodinated contrast allergy
  • Elevated heart rate which cannot be controlled sufficiently to achieve a good CT angiogram
  • Body weight >350lbs
  • Sinus rhythm rate greater than 100 beats per minute at screening
  • Atrial fibrillation with average heart rate of greater than 70 beats per minute on resting screening ECG