Ensayos clínicos

Inclusion Criteria

Prior to enrollment in the Registry, candidates must meet the following inclusion criteria:

• Diagnosis of WHO Group I PAH (< 6 months) including the following subgroups:

1. Pulmonary Arterial Hypertension (PAH)

1. Idiopathic PAH
2. Heritable PAH
   1. ALK-1, ENG,SMAD9, CAV1, KCNK3
   2. Drug and toxin induced Associated With:
      1. Connective tissue disease
      2. HIV infection
      3. Portal hypertension
      4. Congenital systemic to pulmonary shunts
    1’ Pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis
   • Documentation of the following hemodynamic parameters by pulmonary artery Catheterization
   • Mean pulmonary arterial pressure (PAPm) ≥ 25 mm Hg at rest and,
   • Pulmonary artery wedge pressure (PAWP) or left ventricular end diastolic pressure (LVEDP) ≤ 15 mm Hg in the absence of mitral stenosis and,
   • Pulmonary vascular resistance (PVR) > 3 Wood Units  
   • Patient has consented to participate in the NHLBI sponsored R24HL105333 National Biological Sample and Data Repository for PAH  
   •  
   •  Exclusion Criteria
               Patients not eligible for enrollment include:
   • Patients unwilling or unable to provide written consent for participation in the study.
   • Patients with an underlying medical disorder (e.g. metastatic cancer) with an anticipated life expectancy less than 2 years.
   • Patients who do not meet inclusion criteria including:
     • Have not had documentation of hemodynamic criteria by pulmonary artery catheterization as outlined in the inclusion criteria
     • Meet the criteria for inclusion into WHO Diagnostic Groups II, III, IV or V