Ensayos clínicos

Inclusion Criteria 

Children with Hypothalamic Ovesity:

• History of a tumor in the sellar/suprasellar region with hypothalamic involvement
• Age 2-17 years
• Stable hormone replacement therapy for more than 6 months (with levothyroxine, glucocorticoids and sex steroids)

Control Samples:

• Patients with simple obesity who have previously participated in a clinical trial aimed at studying the effect of vitamin-D supplementation on insulin action
• Age 12-18 years

Exclusion Criteria: 

• Untreated pituitary dysfunction except for untreated growth hormone deficiency
• Type 1 or 2 diabetes mellitus
• Previous (within 6-months) or current use of weight loss medication
• Previous (within 6-months) or current use of drugs associated with weight gain (e.g. steroids/anti-psychotics)
• Previous bariatric surgery
• Recent initiation (within 3-months) of anti-hypertensive or lipid medication
• Obesity associated with genetic disorder (monogenetic obesity)

Control Samples:

• Hepatic or Renal disorders.
• Type 1 or Type 2 diabetes mellitus.
• Ongoing use of insulin, metformin, or oral hypoglycemic medications.
• Malabsorption disorders (celiac disease, cystic fibrosis, and inflammatory bowel disease.
• Serum 25(OH) D > 100 ng/mL, and serum calcium > 10.8 mg/dL.
• Use of glucocorticoids or anti-seizure medications in the preceding 6 months, ongoing multivitamin supplementation