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A Study of Prolactin Levels in Women with Chronic Migraine

Overview

Información sobre este estudio

The purpose of this study is to identify whether there is a difference in prolactin levels between patients with chronic migraine and healthy controls. This may help to explain the sensitivity to pain those patients with chronic migraine experience and may also help to establish a target for new treatments of chronic migraine

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria

  • Cases
    • Female
    • Age 18-50 years
    • Diagnosis of chronic migraine as defined by the ICHD III beta criteria
    • Must self-report a typically regular menstrual cycle
  • Controls
    • Female
    • Healthy 
    • Age 18-50 years
    • Must self-report a typically regular menstrual cycle

Exclusion Criteria

  • Cases
    • Has significantly elevated anxiety and depression inventory scores (GAD-7 score of 10 or higher and PHQ-9 score of 10 or higher)
    • Self-reports an unreliable menstrual cycle
    • A history of a pituitary adenoma or history of spontaneous galactorrhea
    • Has known hyperprolactinemia
    • Currently taking medications which can affect serum prolactin levels (drugs are listed below)
    • Pregnant or breastfeeding
    • History of schizophrenia or psychosis
  • Controls
    • Has significantly elevated anxiety and depression inventory scores (GAD-7 score of 10 or higher and PHQ-9 score of 10 or higher)
    • Of reproductive age with menstrual cycles  impossible to predict
    • A history of pituitary adenoma or history of spontaneous galactorrhea
    • Has known hyperprolactinemia
    • Currently taking any drugs which can affect serum prolactin levels (drugs are listed below)
    • Pregnant or breastfeeding
    • History of schizophrenia or psychosis
  • Drugs that affect prolactin levels that will exclude both cases and controls
    • Chlorpromazine
    • Fluphenazine
    • Haloperidol
    • Loxapine 
    • Perphenazine
    • Pimozide
    • Thiothixene
    • Trifluoperazine
    • Aripiprazole
    • Asenapine
    • Clozapine
    • Ilperidone
    • Lurasidone
    • Olanzepine
    • Paliperidone
    • Quetiapine
    • Risperidone
    • Ziprasidone
    • Amitriptyline
    • Desipramine
    • Clomipramine
    • Metoclopramide 
    • Domperidone
    • Prochrlorperazine
    • Verapamil
    • Methyldopa
    • Methadone
    • Morphine
    • Hydropmorphone
    • Oxydocone
    • Hydrocodone
    • Codeine

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Amaal Starling, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20268655

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