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A Study of the Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

Overview

Información sobre este estudio

Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications following cardiac surgery with cardiopulmonary bypass that are thought to associated with inflammation. Some studies have shown that ketamine does decrease these complications when compared with anesthetics that are not commonly used in our cardiac anesthesiology practice. Propofol is another commonly used anesthetic medication which is used for induction of anesthesia. Ketamine has not been compared with propofol for potential to reduce post-operative complications associated with the inflammatory process. This study aims to see if ketamine will reduce the incidence of cognitive dysfunction, delirium, and renal dysfunction in comparison with propofol. In addition, the hemodynamic impact of ketamine compared with propofol will be investigated.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Scheduled to undergo cardiac surgery

Inclusion Criteria:

  • Age greater than or equal to 70 years presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota
  • Schedule to undergo complex cardiac surgery
    • Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and CABG procedures

Exclusion Criteria:

  • Left or right ventricular assist device implantation or explantation
  • Procedures not requiring cardiopulmonary bypass
  • Active infection or sepsis, severe hepatic disease or ascites
  • Pre-operative renal dysfunction including a baseline creatinine equal to or greater than 2.0 mg/dL or requiring dialysis
  • Immunosuppressive medication use (including steroid use)
  • Immunodeficiency syndrome
  • Known neurologic or psychiatric disorder or
  • Use of drugs for psychosis

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Erica Wittwer, M.D., Ph.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20152422

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