Ensayos clínicos

Inclusion Criteria

• No abdominal surgery (except appendectomy, cholecystectomy, hernia repair, hysterectomy, and C-section).
• Written informed consent.
• Patient is healthy control, IBS-C, or IBS-D confirmed by Rome III criteria.

Exclusion Criteria

• Females who are pregnant or breastfeeding.
• Use of tobacco products within the past 6 months (since nicotine may affect intestinal permeability).
• Use of NSAIDs or aspirin within the past week (since NSAIDs affect intestinal permeability).
• Use of oral corticosteroids within the previous 6 weeks.
• Ingestion of artificial sweeteners such as Splenda TM (sucralose), Nutrasweet TM (aspartame), lactulose or mannitol 2 days before the study tests begins; e.g., foods to be avoided are sugarless gyms or mints and diet soda.
• Ingestion of any prescription, over the counter, or herbal medications which can affect gastrointestinal transit 7 days before the study begins.
• Proton pump inhibitors.
• Antibiotics for the preceding 60 days before the start of the study.
• Alcohol intake beyond the recommended safe limit (<21 units per week).
• Bleeding disorders or medications that increase risk of bleeding from mucosal biopsies.
• Known allergy to fluorescein.
• Inflammatory bowel diseases, celiac disease.