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Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms

Overview

Información sobre este estudio

Cystic tumors of the pancreas are fluid-filled growths. They are often treated by surgical removal. A safe and effective non-surgical treatment is desirable. Ethanol (alcohol) injection may treat cysts by killing the lining cells of the cyst, and is an accepted treatment for cysts of other organs. In this study, participants with pancreatic cysts will undergo endoscopic ultrasound (EUS) guided ethanol injection of pancreatic cysts. This is a pilot study to assess safety and efficacy.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Presence of a pancreatic cystic lesion, > 1.5 cm in maximum diameter
  • Treatment of the cystic lesion is desired due to symptoms or concern for subsequent malignancy
  • Age > or = 18 years
  • Able to give informed consent
  • Surgical treatment has been considered, and a surgical consultation offered to the patient, but the subject's cyst does not meet consensus criteria for surgical resection, or the subject is deemed a poor operative candidate, or ethanol ablation would allow a subtotal rather than total pancreatectomy, or the subject has decided not to undergo surgical treatment.

Exclusion Criteria:

  • Known or suspected pregnancy, or nursing
  • History of pancreatitis within past 3 months
  • Main pancreatic duct is dilated to > 4mm in body or tail
  • Cyst is known to communicate with the pancreatic duct
  • Cyst has a primarily microcystic architecture on EUS
  • Cyst is immediately adjacent to the main pancreatic duct on EUS
  • Cyst has a connection to the main pancreatic duct seen during EUS
  • During initial cyst aspiration, more fluid is recovered than expected (suggesting communication to the main pancreatic duct)
  • Pancreatic cytology has demonstrated cancer

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Mark Topazian, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20118287

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