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Evaluation of the Effect of Fasting and Exercise on Uptake of Tc-99m Sestamibi in Breast Tissue

Overview

Información sobre este estudio

The primary objective of this study is to determine if exercise, fasting, or eating prior to the molecular breast imaging study will have an effect on the uptake of the tracer in the breast tissue.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion criteria:

Arm 1:

  1. Able to fast overnight or for 6 hours
  2. Non-diabetic
  3. Age > 40 years
  4. Negative pregnancy test, postmenopausal, or surgically sterilized
  5. Negative mammogram at Mayo Clinic within the last 15 months (defined as screening mammogram or subsequent diagnostic workup with BI-RADS 1 or 2 final assessment)
  6. No current breast concerns

Arm 2:

  1. Able to fast overnight or for 6 hours
  2. Able to perform light to moderate exercise on an exercise bike
  3. Non-diabetic and Body Mass Index < 25
  4. Age > 40 years and < 70 years
  5. Negative pregnancy test, postmenopausal, or surgically sterilized
  6. Negative mammogram at Mayo Clinic within the last 15 months (defined as screening mammogram or subsequent diagnostic workup with BI-RADS 1 or 2 final assessment)
  7. No current breast concerns 8. No history of coronary artery disease, angina, stroke or peripheral arterial disease.

Arm 3:

  1. Able to fast overnight or for 6 hours
  2. Willing to consume a dose of caffeine (200 mg), equivalent to that of an 8 oz Starbuck brewed coffee.
  3. Non-diabetic
  4. Age > 40 years
  5. Negative pregnancy test, postmenopausal, or surgically sterilized
  6. Negative mammogram at Mayo Clinic within the last 15 months (defined as screening mammogram or subsequent diagnostic workup with BI-RADS 1 or 2 final assessment)
  7. No current breast concerns

Arm 4:

  1. Able to fast overnight or for 6 hours
  2. Non-diabetic
  3. Age > 40 years
  4. Negative pregnancy test, postmenopausal, or surgically sterilized
  5. Negative mammogram at Mayo Clinic within the last 15 months (defined as screening mammogram or subsequent diagnostic workup with BI-RADS 1 or 2 final assessment)
  6. No current breast concerns

Exclusion Criteria:

  • Pregnancy test (if necessary) is not negative, or the patient is unable to complete the pregnancy test
  • Physically unable to sit upright and still remain still during two consecutive MBI studies over the course of a 2 hour period.
  • Have undergone unilateral or bilateral mastectomy
  • Breast implants or silicone injections
  • Are unable to understand and sign the consent form

Arm 2-also includes: Unable to perform light to moderate exercise for 12 minutes on a treadmill or a stationary bicycle

Arm 3: Unwilling to consume a 200 mg dose of caffeine

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20112086

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