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Identifying the mechanisms that contribute to excessive unchecked cell growth (neoplasia), and the contribution of damaged non-growing (senescent) cells to human diseases, including arthritis, cardiovascular disease and muscle wasting. More
The Center for Biomedical Discovery's cancer and cell aging biomedical research platform brings together investigators with diverse skills and interests to tackle the complex questions posed by human disease through understanding:
Normal regulated cell growth is required for life, whereas cancer (neoplasia) results from uncontrolled cell growth. Researchers study the mechanisms that control and regulate cell growth, or that fail to do so in cancer.
Cell aging contributes to functional decline of tissues and organs and increases the risk of chronic diseases such as Alzheimer's disease, atherosclerosis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, osteoarthritis and osteoporosis. One type of aged cells, senescent cells, are highly abundant at disease sites, indicating that they are particularly important drivers of pathology. Senescent cells are of particular interest to investigators in the Center for Biomedical Discovery's cancer and cell aging platform.
Team science grants foster new collaborations of scientists from diverse fields to drive innovative, cutting-edge research focused on understanding biological processes that contribute to human disease.
Platform directors and research leaders welcome your input and feedback.