Polycystic kidney disease

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Displaying 1-10 out of 22 doctors available

  1. Andrew J. Bentall, M.B., Ch.B., M.D.

    Andrew J. Bentall, M.B., Ch.B., M.D.

    1. Nephrologist
    2. Transplant Nephrologist
    1. Rochester, MN
    Areas of focus:

    Transplant, Pre-transplant evaluation, Kidney donor evaluation, Immunosuppressive drug therapy, Pancreas transplant, Ki...dney transplant, Living donor kidney transplant, Preventing infection in immunocompromised patient, Preoperative cardiac evaluation, Post-transplant long-term care, Living-donor transplant, Post-kidney transplant care, Post-pancreas transplant care, Pre-kidney transplant evaluation, Pre-pancreas transplant evaluation, Preemptive kidney transplant, Simultaneous pancreas-kidney transplant, Living kidney donation, Living organ donation, Paired kidney donation, Diabetic nephropathy, Secondary high blood pressure, Hyperphosphatemia, Hyperparathyroidism, Nephrotic syndrome, Kidney failure, Renal papillary necrosis, Hydronephrosis, Glomerulonephritis, Renal tubular acidosis, Lupus nephritis, Hyperoxaluria, Kidney infection, Chronic kidney disease, End-stage renal disease, Polycystic kidney disease, Renal cell carcinoma, IgA nephropathy, Minimal change disease, Primary hyperoxaluria, Acute kidney injury , Secondary hyperparathyroidism, Tertiary hyperparathyroidism, Inherited cystic kidney disorder, Renovascular disease, Simple kidney cyst, Membranoproliferative glomerulonephritis, Hypertensive nephropathy, Metabolic acidosis, Renal parenchymal disease, Immunotactoid glomerulonephritis, Thin basement membrane disease, Hereditary nephritis, Renovascular hypertension, Malignant hypertension, Post-transplant hypertension, Interstitial nephritis, Myeloma kidney disease, Metabolic kidney disease, Renal amyloidosis

  2. Fouad T. Chebib, M.D.

    Fouad T. Chebib, M.D.

    1. Jacksonville, FL
    Areas of focus:

    Transplant, Pancreas transplant, Kidney transplant, Kidney dialysis, High blood pressure, Kidney stone, Chronic kidney ...disease, End-stage renal disease, Acute kidney failure, Polycystic kidney disease, Glomerular disease, Kidney cyst

  3. Carl H. Cramer, II, M.D.

    Carl H. Cramer, II, M.D.

    1. Transplant Nephrologist
    2. Pediatrician
    3. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Dialysis, Hemodialysis, Peritoneal dialysis, High blood pressure, Secondary high blood pressure, Nep...hrotic syndrome, Renal artery stenosis, Kidney failure, Hydronephrosis, Shrinking kidney, Glomerulonephritis, Renal tubular acidosis, Lupus nephritis, Blood in urine, Nail disease, Urinary tract infection, Horseshoe kidney, Protein in urine, Single kidney, Kidney infection, Congenital kidney disorder, Postural proteinuria, High blood pressure in children, Childhood nephrotic syndrome, Chronic kidney disease, End-stage renal disease, Kidney injury, Polycystic kidney disease, IgA nephropathy, Glomerular disease, Minimal change disease, Focal segmental glomerulosclerosis, Acute kidney injury , Tuberous sclerosis, Renovascular disease, Nephritis, Kidney cyst, Multicystic kidney dysplasia, Membranoproliferative glomerulonephritis, Medullary sponge kidney, Kidney angiomyolipoma, Thin basement membrane disease, Hereditary nephritis, Renovascular hypertension, Malignant hypertension, Post-transplant hypertension, Interstitial nephritis

  4. Neera K. Dahl, M.D., Ph.D.

    Neera K. Dahl, M.D., Ph.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney stone, Genetic disorder, Polycystic kidney disease, Polycystic liver disease

  5. Patrick G. Dean, M.D.

    Patrick G. Dean, M.D.

    1. Transplant Surgeon
    Areas of focus:

    Transplant, Pancreas transplant, Kidney transplant, Islet cell transplant, Diabetes, End-stage renal disease, Polycysti...c kidney disease, ADPKD

  6. Navin R. Gupta, M.D.

    Navin R. Gupta, M.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    High blood pressure, Kidney stone, Alport syndrome, Chronic kidney disease, Polycystic kidney disease, Focal segmental ...glomerulosclerosis, Acute kidney injury

  7. Christian Hanna, M.D., M.S.

    Christian Hanna, M.D., M.S.

    1. Pediatric Nephrologist
    1. Rochester, MN
    Areas of focus:

    Kidney transplant, Dialysis, Continuous renal replacement therapy, Hemodialysis, Peritoneal dialysis, Hemolytic uremic ...syndrome, Nephrotic syndrome, Renal artery stenosis, Hydronephrosis, Kidney stone, Renal tubular acidosis, Blood in urine, Urinary tract infection, Horseshoe kidney, Protein in urine, Single kidney, Kidney infection, Congenital kidney disorder, Postural proteinuria, High blood pressure in children, Childhood nephrotic syndrome, Chronic kidney disease, End-stage renal disease, Polycystic kidney disease, IgA nephropathy, Glomerular disease, Minimal change disease, Focal segmental glomerulosclerosis, Membranous nephropathy, Acute kidney injury , Inherited cystic kidney disorder, Renovascular disease, Kidney cyst, Multicystic kidney dysplasia, Membranoproliferative glomerulonephritis, Medullary sponge kidney

  8. Marie C. Hogan, M.D., Ph.D.

    Marie C. Hogan, M.D., Ph.D.

    1. Internist
    2. Nephrologist
    1. Rochester, MN
    Areas of focus:

    End-stage renal disease, Polycystic kidney disease, IgA nephropathy, Glomerular disease, Focal segmental glomeruloscler...osis

  9. Musab S. Hommos, M.B.B.S.

    Musab S. Hommos, M.B.B.S.

    1. Nephrologist
    1. Phoenix, AZ
    Areas of focus:

    High blood pressure, Amyloidosis, Renal artery stenosis, Glomerulonephritis, Renal tubular acidosis, Chronic kidney dis...ease, End-stage renal disease, Polycystic kidney disease, Acute kidney injury

  10. Tambi Jarmi, M.D.

    Tambi Jarmi, M.D.

    1. Transplant Nephrologist
    1. Jacksonville, FL
    Areas of focus:

    Pre-transplant evaluation, Immunosuppressive drug therapy, Pancreas transplant, Kidney transplant, Post-transplant long...-term care, Diabetic nephropathy, Chronic kidney disease, End-stage renal disease, Acute kidney failure, Polycystic kidney disease

Research

Mayo Clinic is a leader in polycystic kidney disease research. Mayo Clinic researchers discovered:

  • The main gene that causes autosomal dominant polycystic kidney disease (ADPKD)
  • The gene that causes autosomal recessive polycystic kidney disease (ARPKD)
  • A gene that causes a rare form of polycystic kidney disease associated with multiple malformations (Meckel-Gruber syndrome)
  • The polycystic kidney disease proteins polycystin 1, polycystin 2 and fibrocystin
  • The polycystic kidney and liver disease gene GANAB
  • Other genes that cause kidney cyst disease, such as DNAJB11
  • A way to use CT and MRI scans to classify polycystic kidney disease and select people for clinical trials of new therapies
  • A pioneering approach to surgery to remove diseased kidneys and transplant healthy kidneys during the same surgery

Lab-based research at Mayo Clinic has focused on:

  • Explaining how mutations in the polycystic kidney disease genes lead to cyst development
  • Preclinical studies in drug therapies for polycystic kidney disease, such as octreotide and vasopressin antagonists
  • Finding effective therapies for polycystic kidney disease and liver disease
  • Improving imaging assessments of polycystic kidney and liver disease
  • Studies of polycystic kidney disease proteins in urine particles known as exosomes
  • Testing new compounds in animal models of polycystic kidney disease
  • Studies of the hairlike structures (primary cilia) implicated in polycystic kidney disease

Mayo research has shown that a new drug (tolvaptan) can dramatically slow the development and progression of polycystic kidney disease in animal models.

Mayo researchers have also shown that another drug (octreotide) delays the development of both polycystic kidney disease and polycystic liver disease and is a potential treatment option for people with liver involvement.

These medications are now in clinical trials and tolvaptan is approved for use in some countries for polycystic kidney disease. In addition, nephrologists at Mayo Clinic are working to understand how to prevent the progression of kidney (renal) disease in patients with polycystic kidney disease.

Read more about the extensive research being done at Mayo Clinic's Robert M. and Billie Kelley Pirnie Translational Polycystic Kidney Disease (PKD) Center.

The Mayo Nephrology Collaborative Group — a consortium of nephrologists located across the United States — develops and conducts studies aimed at improving treatment of patients with renal diseases, including polycystic kidney disease.

Publications

See a list of publications by Mayo Clinic doctors on polycystic kidney disease on PubMed, a service of the National Library of Medicine.

Research Profiles

By Mayo Clinic Staff

Polycystic kidney disease care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
Jan. 25, 2024
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Polycystic kidney disease

Research: It's all about patients

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Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.