Publications

1. Zhou JX, Li LX, Zhang H, Agborbesong E, Harris PC, Calvet JP, Li X. DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease. Kidney Int. 2024 May 21 [Epub ahead of print]
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2. Zhou JX, Cheng AS, Chen L, Li LX, Agborbesong E, Torres VE, Harris PC, Li X. CD74 Promotes Cyst Growth and Renal Fibrosis in Autosomal Dominant Polycystic Kidney Disease. Cells. 2024 Mar 11; 13 (6)
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3. Agborbesong E, Zhou JX, Zhang H, Li LX, Harris PC, Calvet JP, Li X. Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability. Biomedicines. 2024 Mar 7; 12 (3) Epub 2024 Mar 07
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4. Firdaus Z, Li X. Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches. Int J Mol Sci. 2024 Feb 15; 25 (4)
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5. Zhang L, Zhang H, Agborbesong E, Zhou JX, Li X. Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis. Cell Death Dis. 2023 Dec 5; 14 (12):795 Epub 2023 Dec 05
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6. Agborbesong E, Bissler J, Li X. Liquid Biopsy at the Frontier of Kidney Diseases: Application of Exosomes in Diagnostics and Therapeutics. Genes (Basel). 2023 Jun 28; 14 (7) Epub 2023 June 28
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7. Cheng AS, Li X. The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury. Int J Mol Sci. 2023 May 4; 24 (9) Epub 2023 May 04
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8. Samarpita S, Li X. Leveraging Exosomes as the Next-Generation Bio-Shuttles: The Next Biggest Approach against Th17 Cell Catastrophe. Int J Mol Sci. 2023 Apr 21; 24 (8)
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9. Yu W, Wang G, Li X, Li LX, Zhang H, Gui X, Zhou JX, Calvet JP, Li X. Transcription factor FoxM1 promotes cyst growth in PKD1 mutant ADPKD. Hum Mol Genet. 2023 Mar 20; 32 (7):1114-1126
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10. Agborbesong E, Zhou JX, Li LX, Harris PC, Calvet JP, Li X. Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Hum Mol Genet. 2023 Jan 27; 32 (4):567-579
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11. Woolbright BL, Rajendran G, Abbott E, Martin A, Amalraj S, Dennis K, Li X, Warrick J, Taylor JA 3rd. Role of MIF1/MIF2/CD74 interactions in bladder cancer. J Pathol. 2023 Jan; 259 (1):46-55 Epub 2022 Nov 09
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12. Zou J, Yu C, Zhang C, Guan Y, Zhang Y, Tolbert E, Zhang W, Zhao T, Bayliss G, Li X, Ye Z, Zhuang S. Inhibition of MLL1-menin interaction attenuates renal fibrosis in obstructive nephropathy. FASEB J. 2023 Jan; 37 (1):e22712
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13. Li LX, Zhang X, Zhang H, Agborbesong E, Zhou JX, Calvet JP, Li X. Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys. Cells. 2022 Dec 22; 12 (1)
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14. Zhou JX, Agborbesong E, Li LX, Li X. Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC Progression. Int J Mol Sci. 2022 Dec 2; 23 (23) Epub 2022 Dec 02
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15. Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu ASL, Li X, Calvet JP. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1; 323 (4):F492-F506 Epub 2022 Aug 18
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16. Li LX, Zhang L, Agborbesong E, Zhang X, Zhou JX, Li X. Cross talk between lysine methyltransferase Smyd2 and TGF-beta-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Aug 1; 323 (2):F227-F242 Epub 2022 June 27
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17. Zhang X, Zhou W, Niu Y, Zhu S, Zhang Y, Li X, Yu C. Lysyl oxidase promotes renal fibrosis via accelerating collagen cross-link driving by beta-arrestin/ERK/STAT3 pathway. FASEB J. 2022 Aug; 36 (8):e22427
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18. Zhang X, Li X. Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential. Metabolites. 2022 Jan 10; 12 (1)
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19. Zhang X, Li LX, Yu C, Nath KA, Zhuang S, Li X. Targeting lysine-specific demethylase 1A inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis. FASEB J. 2022 Jan; 36 (1):e22122
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20. Agborbesong E, Li LX, Li L, Li X. Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD. Front Mol Biosci. 2022; 9:922428 Epub 2022 June 29
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21. Agborbesong E, Zhou JX, Li LX, Calvet JP, Li X. Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability. FASEB J. 2022 Jan; 36 (1):e22089
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22. Zhang L, Tian M, Song Y, Liang W, Li X, Tong Y, Wang H. Urinary SARS-CoV-2 RNA Is an Indicator for the Progression and Prognosis of COVID-19. Diagnostics (Basel). 2021 Nov 12; 11 (11)
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23. Zhang X, Li LX, Ding H, Torres VE, Yu C, Li X. Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models. J Am Soc Nephrol. 2021 Nov; 32 (11):2759-2776
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24. Zhang X, Agborbesong E, Li X. The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential. Int J Mol Sci. 2021 Oct 19; 22 (20)
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25. Chan K, Li X. Current Epigenetic Insights in Kidney Development. Genes (Basel). 2021 Aug 21; 12 (8)
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26. Ding H, Li LX, Harris PC, Yang J, Li X. Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease. Nat Commun. 2021 Jul 27; 12 (1):4548 Epub 2021 July 27
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27. Li LX, Li X. Epigenetically Mediated Ciliogenesis and Cell Cycle Regulation, and Their Translational Potential. Cells. 2021 Jul 2; 10 (7) Epub 2021 July 02
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28. Liu L, Liu F, Guan Y, Zou J, Zhang C, Xiong C, Zhao TC, Bayliss G, Li X, Zhuang S. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis. FASEB J. 2021 Jul; 35 (7):e21715
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29. Zhang L, Li X. DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy. Cells. 2021 Jun 18; 10 (6) Epub 2021 June 18
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30. Zhou JX, Li X. Non-Coding RNAs in Hereditary Kidney Disorders. Int J Mol Sci. 2021 Mar 16; 22(6).
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31. Ding H, Zhang L, Yang Q, Zhang X, Li X. Epigenetics in kidney diseases. Adv Clin Chem. 2021; 104:233-297 Epub 2020 Oct 21
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32. Merlin JPJ, Li X. Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases. Front Genet. 2021; 12:817974 Epub 2022 Jan 05
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33. Li LX, Zhou JX, Wang X, Zhang H, Harris PC, Calvet JP, Li X. Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis. Sci Adv. 2020 Oct; 6 (44) Epub 2020 Oct 30
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34. El Ters M, Zhou X, Lepping RJ, Lu P, Karcher RT, Mahnken JD, Brooks WM, Winklhofer FT, Li X, Yu ASL. Biological Efficacy and Safety of Niacinamide in Patients With ADPKD. Kidney Int Rep. 2020 Aug; 5(8):1271-1279. Epub 2020 Jun 10.
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35. Yan Q, Zhu K, Zhang L, Fu Q, Chen Z, Liu S, Fu D, Nakazato R, Yoshioka K, Diao B, Ding G, Li X, Wang H. A negative feedback loop between JNK-associated leucine zipper protein and TGF-beta1 regulates kidney fibrosis. Commun Biol. 2020 Jun 5; 3 (1):288 Epub 2020 June 05
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36. Li X. Epigenetics and cell cycle regulation in cystogenesis. Cell Signal. 2020 Apr; 68:109509 Epub 2019 Dec 23
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37. Zhang L, Li LX, Zhou JX, Harris PC, Calvet JP, Li X. RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD. Theranostics. 2020; 10 (18):8281-8297 Epub 2020 July 09
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38. Li Q, Cui S, Ma Q, Liu Y, Yu H, Geng G, Agborbesong E, Ren C, Wei K, Zhang Y, Yang J, Bai X, Cai G, Xie Y, Li X, Chen X. Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. JCI Insight. 2019 Sep 19; 4 (18) Epub 2019 Sept 19
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39. Salah SM, Meisenheimer JD, Rao R, Peda JD, Wallace DP, Foster D, Li X, Li X, Zhou X, Vallejo JA, Wacker MJ, Fields TA, Swenson-Fields KI. MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease. Am J Physiol Renal Physiol. 2019 Aug 01; 317(2):F343-F360. Epub 2019 May 15.
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40. Li LX, Agborbesong E, Zhang L, Li X. Investigation of epigenetics in kidney cell biology. Methods Cell Biol. 2019; 153:255-278 Epub 2019 June 13
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41. Trott JF, Hwang VJ, Ishimaru T, Chmiel KJ, Zhou JX, Shim K, Stewart BJ, Mahjoub MR, Jen KY, Barupal DK, Li X, Weiss RH. Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis. Am J Physiol Renal Physiol. 2018 Dec 1; 315 (6):F1855-F1868 Epub 2018 Oct 03
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42. Li LX, Zhou JX, Calvet JP, Godwin AK, Jensen RA, Li X. Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. Cell Death Dis. 2018 Feb 27; 9 (3):326
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43. Zhang HB, Wang XD, Xu K, Li XG. The progress of prophylactic treatment in retinopathy of prematurity. Int J Ophthalmol. 2018; 11 (5):858-873 Epub 2018 May 18
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44. Hwang VJ, Zhou X, Chen X, Trott J, Abu Aboud O, Shim K, Dionne LK, Chmiel KJ, Senapedis W, Baloglu E, Mahjoub MR, Li X, Weiss RH. Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease. Kidney Int. 2017 Oct; 92(4):922-933. Epub 2017 May 23.
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45. Raman A, Reif GA, Dai Y, Khanna A, Li X, Astleford L, Parnell SC, Calvet JP, Wallace DP. Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease. J Am Soc Nephrol. 2017 Sep; 28 (9):2708-2719 Epub 2017 May 18
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46. Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017 Jun 30; 127 (7):2751-2764 Epub 2017 June 12
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47. Kakade VR, Tao S, Rajagopal M, Zhou X, Li X, Yu AS, Calvet JP, Pandey P, Rao R. A cAMP and CREB-mediated feed-forward mechanism regulates GSK3ß in polycystic kidney disease. J Mol Cell Biol. 2016 Dec; 8(6):464-476. Epub 2016 May 04.
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48. Zhou X, Fan LX, Peters DJ, Trudel M, Bradner JE, Li X. Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. Hum Mol Genet. 2015 Jul 15; 24(14):3982-93. Epub 2015 Apr 15.
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49. Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X. Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest. 2015 Jun; 125(6):2399-412. Epub 2015 May 11.
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50. Zhang H, Wang X, Xu K, Wang Y, Wang Y, Liu X, Zhang X, Wang L, Li X. 17beta-estradiol ameliorates oxygen-induced retinopathy in the early hyperoxic phase. Biochem Biophys Res Commun. 2015 Feb 20; 457 (4):700-5 Epub 2015 Jan 22
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51. Zhou JX, Fan LX, Li X, Calvet JP, Li X. TNFa signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling. PLoS One. 2015; 10(6):e0131043. Epub 2015 Jun 25.
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52. Tran PV, Sharma M, Li X, Calvet JP. Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis? Birth Defects Res C Embryo Today. 2014 Jun; 102 (2):159-73 Epub 2014 May 26
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53. Yao G, Su X, Nguyen V, Roberts K, Li X, Takakura A, Plomann M, Zhou J. Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. Hum Mol Genet. 2014 May 15; 23 (10):2769-79 Epub 2014 Jan 02
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54. Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X. SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet. 2014 Mar 15; 23(6):1644-55. Epub 2013 Nov 07.
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55. Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X. Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts. J Am Soc Nephrol. 2013 Dec; 24(12):2010-22. Epub 2013 Aug 29.
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56. Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul; 123(7):3084-98. Epub 2013 Jun 17.
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57. Fan LX, Li X, Magenheimer B, Calvet JP, Li X. Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. Kidney Int. 2012 Jan; 81 (1):76-85 Epub 2011 Sept 07
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58. Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012; 7 (11):e49418 Epub 2012 Nov 13
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59. Li X. Epigenetics and autosomal dominant polycystic kidney disease. Biochim Biophys Acta. 2011 Oct; 1812 (10):1213-8 Epub 2010 Oct 20
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60. Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010 Apr; 137 (7):1075-84 Epub 2010 Feb 24
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61. Li X, Magenheimer BS, Xia S, Johnson T, Wallace DP, Calvet JP, Li R. A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat Med. 2008 Aug; 14 (8):863-8 Epub 2008 June 15
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62. Starremans PG, Li X, Finnerty PE, Guo L, Takakura A, Neilson EG, Zhou J. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int. 2008 Jun; 73 (12):1394-405 Epub 2008 Apr 02
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63. Wang S, Zhang J, Nauli SM, Li X, Starremans PG, Luo Y, Roberts KA, Zhou J. Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol. 2007 Apr; 27 (8):3241-52 Epub 2007 Feb 05
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64. Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol. 2005 Dec; 7 (12):1202-12 Epub 2005 Nov 27
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65. Delmas P, Nauli SM, Li X, Coste B, Osorio N, Crest M, Brown DA, Zhou J. Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J. 2004 Apr; 18 (6):740-2 Epub 2004 Feb 06
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66. Luo Y, Vassilev PM, Li X, Kawanabe Y, Zhou J. Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol. 2003 Apr; 23 (7):2600-7
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67. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33 (2):129-37 Epub 2003 Jan 06
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68. Delmas P, Nomura H, Li XG, Lakkis M, Luo Y, Segal Y, Fernandez-Fernandez JM, Harris P, Frischauf AM, Brown DA, Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem. 2002 Mar 29; 277(13):11276-83.
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69. Dai S, Gao M, Li X, Li R. [Distribution of Bacillus thuringiensis in soils of north and south of China]. Wei Sheng Wu Xue Bao. 1996 Aug; 36 (4):295-302
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70. Duan X, Li X, Xue Q, Abo-el-Saad M, Xu D, Wu R. Transgenic rice plants harboring an introduced potato proteinase inhibitor II gene are insect resistant. Nat Biotechnol. 1996 Apr; 14 (4):494-8
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71. Duan X, Li X, Xue Q, Abo-El-Saad M, Wu R. Potato proteinase inhibitor II gene that confers insect resistance in transgenic rice plants Rice Genetics III. 1996.
    
72. Li X, Li R. Coleopterancidal g-endotoxin and constructing its genomic library Journal of biotechnology. 1994; (10):75-83.
    
73. Li R, Dai S, Li X, Zhao Y, Sun C. [Morphology and delta-endotoxin proteins of Bacillus thuringiensis from soils and their toxicities to insects]. Wei Sheng Wu Xue Bao. 1992 Dec; 32 (6):387-93
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74. Li X, Dai S, Gao M, Li R. The fermentative properties of some new highly efficient and peculiar insecticidal strains of Bacillus thuringiensis Microbiology. 1992; IV:88-92.
    
75. Li X, Dai S, Li R. The effect of chemical auxiliaries on BT and preparation of new suspension emulsion form Microbiology. 1991; (18):68-71.
    
76. Li R, Dai S. The new highly efficienct mosquitocidal strains of Bacillus thuringiensis and Bacillius sphaericus The Chinese Journal of Vector Biology and Control. 1991; (2):36-37.
    
77. Li R, Li X, Dai S. The effect of chemical and conditions of storage on y-endotoxin of Bacillus thuringiensis Microbiology. 1991; (18):5-8.
    
78. Li R, Dai S, Li X, Luo C, Sheng Z, Sun M. [Survey of Bacillus thuringiensis and Bacillus sphaericus from soils of four provinces of China and their principal biological properties]. Wei Sheng Wu Xue Bao. 1990 Oct; 30 (5):380-8
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