Publications

1. Sadighi Akha AA, Csomos K, Ujhazi B, Walter JE, Kumanovics A. Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders. Clin Lab Med. 2023 Sep; 43 (3):467-483 Epub 2023 June 09
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2. Kumanovics A, Sadighi Akha AA. Flow cytometry for B-cell subset analysis in immunodeficiencies. J Immunol Methods. 2022 Oct; 509:113327 Epub 2022 Aug 05
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3. Sadighi Akha AA, Kumanovics A. Anti-cytokine autoantibodies and inborn errors of immunity. J Immunol Methods. 2022 Sep; 508:113313 Epub 2022 July 09
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4. Byeon SK, Madugundu AK, Garapati K, Ramarajan MG, Saraswat M, Kumar-M P, Hughes T, Shah R, Patnaik MM, Chia N, Ashrafzadeh-Kian S, Yao JD, Pritt BS, Cattaneo R, Salama ME, Zenka RM, Kipp BR, Grebe SKG, Singh RJ, Sadighi Akha AA, Algeciras-Schimnich A, Dasari S, Olson JE, Walsh JR, Venkatakrishnan AJ, Jenkinson G, O'Horo JC, Badley AD, Pandey A. Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study. Lancet Digit Health. 2022 Sep; 4 (9):e632-e645 Epub 2022 July 11
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5. Knight V, Heimall JR, Chong H, Nandiwada SL, Chen K, Lawrence MG, Sadighi Akha AA, Kumanovics A, Jyonouchi S, Ngo SY, Vinh DC, Hagin D, Forbes Satter LR, Marsh RA, Chiang SCC, Willrich MAV, Frazer-Abel AA, Rider NL. A Toolkit and Framework for Optimal Laboratory Evaluation of Individuals with Suspected Primary Immunodeficiency. J Allergy Clin Immunol Pract. 2021 Sep; 9 (9):3293-3307.e6 Epub 2021 May 24
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6. Knight V, Askar MZ, Ntrivalas E, Nandiwada SL, Peterson LK, Tebo AE, Kadkhoda K, Schmitz JL, Naides SJ, Snyder MR, Sadighi Akha AA. Highlights of the 33rd annual scientific meeting of the Association of Medical Laboratory Immunologists (AMLI). J Immunol Methods. 2021 May; 492:112994 Epub 2021 Feb 21
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7. Sadighi Akha AA, Tschumper RC, Mills JR, Isham CR, Witty EE, Viswanatha DS, Dasari S, Snyder MR, Murray DL, Katzmann JA, Jelinek DF, Willrich MAV. A rare case of selective Igkappa chain deficiency: Biologic and clinical implications. J Allergy Clin Immunol 2020 Nov; 146 (5):1208-1210.e6 Epub 2020 Apr 08
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8. Chitty-Lopez M, Westermann-Clark E, Dawson I, Ujhazi B, Csomos K, Dobbs K, Le K, Yamazaki Y, Sadighi Akha AA, Chellapandian D, Oshrine B, Notarangelo LD, Sunkersett G, Leiding JW, Walter JE. Asymptomatic Infant With Atypical SCID and Novel Hypomorphic RAG Variant Identified by Newborn Screening: A Diagnostic and Treatment Dilemma. Front Immunol. 2020; 11:1954 Epub 2020 Sept 29
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9. Siddiqi AE, Liu AY, Charville GW, Kunder CA, Uzel G, Sadighi Akha AA, Oak J, Martin B, Sacha J, Lewis DB, Gernez Y. Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency. J Clin Immunol 2020 Feb; 40 (2):412-414 Epub 2020 Jan 18
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10. Sadighi Akha AA. Aging and the immune system: An overview. J Immunol Methods. 2018 Dec; 463:21-26 Epub 2018 Aug 14
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11. Sadighi Akha AA, McDermott AJ, Theriot CM, Carlson PE Jr, Frank CR, McDonald RA, Falkowski NR, Bergin IL, Young VB, Huffnagle GB. Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice. Immunology. 2015 Apr; 144: (4)587-97.
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12. Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR, Tyra HM, Rutkowski DT, Young VB, Huffnagle GB. Acute infection of mice with Clostridium difficile leads to eIF2alpha phosphorylation and pro-survival signalling as part of the mucosal inflammatory response. Immunology. 2013 Sep; 140(1):111-22.
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13. Murdock BJ, Falkowski NR, Shreiner AB, Sadighi Akha AA, McDonald RA, White ES, Toews GB, Huffnagle GB. Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia. Infect Immun. 2012 Apr; 80(4):1424-36. Epub 2012 Jan 17.
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14. Shreiner AB, Murdock BJ, Sadighi Akha AA, Falkowski NR, Christensen PJ, White ES, Hogaboam CM, Huffnagle GB. Repeated exposure to Aspergillus fumigatus conidia results in CD4+ T cell-dependent and -independent pulmonary arterial remodeling in a mixed Th1/Th2/Th17 microenvironment that requires interleukin-4 (IL-4) and IL-10. Infect Immun. 2012 Jan; 80(1):388-97. Epub 2011 Nov 07.
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15. Erb-Downward JR, Sadighi Akha AA, Wang J, Shen N, He B, Martinez FJ, Gyetko MR, Curtis JL, Huffnagle GB. Use of direct gradient analysis to uncover biological hypotheses in 16s survey data and beyond. Sci Rep. 2012; 2:774. Epub 2012 Oct 26.
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16. Sadighi Akha AA, Harper JM, Salmon AB, Schroeder BA, Tyra HM, Rutkowski DT, Miller RA. Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity. J Biol Chem. 2011 Sep 2; 286(35):30344-51. Epub 2011 Jul 12.
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17. Sun L, Sadighi Akha AA, Miller RA, Harper JM. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci. 2009 Jul; 64(7):711-22. Epub 2009 May 04.
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18. Salmon AB, Sadighi Akha AA, Buffenstein R, Miller RA. Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. J Gerontol A Biol Sci Med Sci. 2008 Mar; 63(3):232-41.
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19. Garcia GG, Sadighi Akha AA, Miller RA. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J Immunol. 2007 Nov 15; 179(10):6403-9.
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20. Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006 Nov; 4(11):e374.
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21. Berger SB, Sadighi Akha AA, Miller RA, Garcia GG. CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes. Immunology. 2006 Oct; 119(2):178-86. Epub 2006 Jun 23.
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22. Sadighi Akha AA, Berger SB, Miller RA. Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice. Immunology. 2006 Oct; 119(2):187-94.
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23. Sadighi Akha AA, Miller RA. Signal transduction in the aging immune system. Curr Opin Immunol. 2005 Oct; 17(5):486-91.
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24. Berger SB, Sadighi Akha AA, Miller RA. A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice. Int Immunol. 2005 Aug; 17(8):983-91. Epub 2005 Jul 6.
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25. Miller RA, Berger SB, Burke DT, Galecki A, Garcia GG, Harper JM, Sadighi Akha AA. T cells in aging mice: genetic, developmental, and biochemical analyses. Immunol Rev. 2005 Jun; 205:94-103.
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26. Garcia GG, Berger SB, Sadighi Akha AA, Miller RA. Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells. Eur J Immunol. 2005 Feb; 35(2):622-31.
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27. Afanasyeva M, Wang Y, Kaya Z, Stafford EA, Dohmen KM, Sadighi Akha AA, Rose NR. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. Circulation. 2001 Dec 18; 104(25):3145-51.
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28. Sadighi Akha AA, Humphrey RL, Winkelstein JA, Loeb DM, Lederman HM. Oligo-/monoclonal gammopathy and hypergammaglobulinemia in ataxia-telangiectasia. A study of 90 patients. Medicine (Baltimore). 1999 Nov; 78(6):370-81.
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29. Korb LC, Mirshahidi S, Ramyar K, Sadighi Akha AA, Sadegh-Nasseri S. Induction of T cell anergy by low numbers of agonist ligands. J Immunol. 1999 Jun 1; 162(11):6401-9.
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30. Sadighi Akha AA, Willmott NJ, Brickley K, Dolphin AC, Galione A, Hunt SV. Anti-Ig-induced calcium influx in rat B lymphocytes mediated by cGMP through a dihydropyridine-sensitive channel. J Biol Chem. 1996 Mar 29; 271(13):7297-300.
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