Publications

  1. Zhang B, Swanson WB, Durdan M, Livingston HN, Dodd M, Vidanapathirana SM, Desai A, Douglas L, Mishina Y, Weivoda M, Greineder CF. Affinity targeting of therapeutic proteins to the bone surface - local delivery of sclerostin neutralizing antibody enhances efficacy. J Bone Miner Res. 2024 Mar 25 [Epub ahead of print]
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  2. Doolittle ML, Eckhardt BA, Vos SJ, Grain S, Rowsey JL, Ruan M, Saul D, Farr JN, Weivoda MM, Khosla S, Monroe DG. Modest Effects of Osteoclast-Specific ERalpha Deletion after Skeletal Maturity. JBMR Plus. 2023 Oct; 7 (10):e10797 Epub 2023 July 13
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  3. Zanwar S, Jacob EK, Greiner C, Pavelko K, Strausbauch M, Anderson E, Arsana A, Weivoda M, Shah MV, Kourelis T. The immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant. Blood Cancer J. 2023 Sep 26; 13 (1):151 Epub 2023 Sept 26
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  4. Emch MJ, Wicik Z, Aspros KGM, Vukajlovic T, Pitel KS, Narum AK, Weivoda MM, Tang X, Kalari KR, Turner RT, Iwaniec UT, Monroe DG, Subramaniam M, Hawse JR. Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization. Mol Ther Nucleic Acids. 2023 Sep 12; 33:28-41 Epub 2023 June 03
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  5. Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023 Apr 17; 133 (8)
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  6. Weivoda MM, Bradley EW. Macrophages and Bone Remodeling. J Bone Miner Res. 2023 Mar; 38 (3):359-369 Epub 2023 Feb 03
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  7. Sharma N, Weivoda MM, Soe K. Functional Heterogeneity Within Osteoclast Populations-a Critical Review of Four Key Publications that May Change the Paradigm of Osteoclasts. Curr Osteoporos Rep. 2022 Oct; 20 (5):344-355 Epub 2022 July 15
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  8. Doolittle ML, Saul D, Kaur J, Rowsey JL, Eckhardt B, Vos S, Grain S, Kroupova K, Ruan M, Weivoda M, Oursler MJ, Farr JN, Monroe DG, Khosla S. Skeletal Effects of Inducible ERalpha Deletion in Osteocytes in Adult Mice. J Bone Miner Res. 2022 Sep; 37 (9):1750-1760 Epub 2022 July 22
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  9. Swanson WB, Durdan M, Eberle M, Woodbury S, Mauser A, Gregory J, Zhang B, Niemann D, Herremans J, Ma PX, Lahann J, Weivoda M, Mishina Y, Greineder CF. A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications. RSC Chem Biol. 2022 Jun 8; 3 (6):748-764 Epub 2022 Apr 29
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  10. Aw Yong KM, Horst E, Neale D, Royzenblat S, Lahann J, Greineder C, Weivoda M, Mehta G, Keller ET. A Bioreactor for 3D In Vitro Modeling of the Mechanical Stimulation of Osteocytes. Front Bioeng Biotechnol. 2022; 10:797542 Epub 2022 Mar 25
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  11. Durdan MM, Azaria RD, Weivoda MM. Novel insights into the coupling of osteoclasts and resorption to bone formation. Semin Cell Dev Biol. 2021 Oct 29 [Epub ahead of print]
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  12. Weivoda MM, Lee SK, Monroe DG. miRNAs in osteoclast biology. Bone. 2021 Feb; 143:115757 Epub 2020 Nov 17
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  13. Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun. 2020 Jan 7; 11 (1):87 Epub 2020 Jan 07
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  14. Olechnowicz SWZ, Weivoda MM, Lwin ST, Leung SK, Gooding S, Nador G, Javaid MK, Ramasamy K, Rao SR, Edwards JR, Edwards CM. Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment. Sci Rep. 2019 Oct 2; 9 (1):14189 Epub 2019 Oct 02
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  15. Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell. 2019 Jun; 18 (3):e12950 Epub 2019 Mar 25
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  16. Aquino-Martinez R, Farr JN, Weivoda MM, Negley BA, Onken JL, Thicke BS, Fulcer MM, Fraser DG, van Wijnen AJ, Khosla S, Monroe DG. miR-219a-5p Regulates Rorbeta During Osteoblast Differentiation and in Age-related Bone Loss. J Bone Miner Res. 2019 Jan; 34 (1):135-144 Epub 2018 Oct 15
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  17. Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018 Aug; 24 (8):1246-1256 Epub 2018 July 09
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  18. Farr JN, Weivoda MM, Nicks KM, Fraser DG, Negley BA, Onken JL, Thicke BS, Ruan M, Liu H, Forrest D, Hawse JR, Khosla S, Monroe DG. Osteoprotection Through the Deletion of the Transcription Factor Rorbeta in Mice. J Bone Miner Res. 2018 Apr; 33 (4):720-731 Epub 2017 Dec 27
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  19. Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017 Sep; 23 (9):1072-1079 Epub 2017 Aug 21
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  20. Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL. Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice. J Gerontol A Biol Sci Med Sci. 2017 Jun 1; 72 (6):780-785
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  21. Weivoda MM, Youssef SJ, Oursler MJ. Sclerostin expression and functions beyond the osteocyte. Bone. 2017 Mar; 96:45-50 Epub 2016 Nov 23
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  22. Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S. Identification of Senescent Cells in the Bone Microenvironment. J Bone Miner Res. 2016 Nov; 31 (11):1920-1929 Epub 2016 Oct 24
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  23. Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling. Sci Signal. 2016 Aug 9; 9 (440):ra79 Epub 2016 Aug 09
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  24. Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ. Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation. J Bone Miner Res. 2016 Jan; 31 (1):76-85 Epub 2015 Aug 06
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  25. Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ. Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. J Bone Miner Res. 2016 Jan; 31 (1):65-75 Epub 2015 Aug 19
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  26. Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife. 2015 Dec 19; 4:e12997
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  27. Kuder CH, Weivoda MM, Zhang Y, Zhu J, Neighbors JD, Wiemer DF, Hohl RJ. 3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines. Lipids. 2015 Dec; 50 (12):1195-207 Epub 2015 Oct 22
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  28. Weivoda MM, Oursler MJ. Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions. Curr Osteoporos Rep. 2014 Mar; 12 (1):107-14
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  29. Weivoda MM, Oursler MJ. The Roles of Small GTPases in Osteoclast Biology. Orthop Muscular Syst. 2014; 3
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  30. Ota K, Quint P, Weivoda MM, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors. Bone. 2013 Nov; 57 (1):68-75 Epub 2013 July 25
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  31. Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F Silent information regulator (Sir)T1 inhibits NFkB signaling to maintain normal skeletal remodeling. Silent information regulator (Sir)T1 inhibits NFkB signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2012; 25:2419-26.
  32. Edwards JR, Weivoda MM. Osteoclasts: malefactors of disease Discov Med. 2012; 13:201-210.
  33. Weivoda MM, Hohl RJ. Geranylgeranyl pyrophosphate stimulates PPAR-gamma expression and adipogenesis through the inhibition of osteoblast differentiation. Bone. 2012; 50:467-476.
  34. Weivoda MM, Hohl RJ. The effects of farnesyl pyrophsophate accumulation on calvarial osteoblast differentiation. Endocrinology. 2011; 152:3113-22.
  35. Weivoda MM, Hohl RJ. The effects of geranylgeranyl diphosphate synthase inhibition on osteoblast differentiation. J Cell Biochem. 2011; 112:1506-13.
  36. Edwards JR, Nyman JS, Lwin ST, Moore MM, Esparza J, O’Quinn EC, Hart AJ, Biswas S, Patil CA, Lonning S, Mahadevan-Jansen A, Mundy GR. Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo. J Bone Miner Res. 2010; 25:2419-26.
  37. Kirstein MN, Root SA, Moore MM, Wieman KM, Williams BW, Jacobson PA, Marker PH, Tuttle TM. Exposure-response relationships for oxaliplatin-treated colon cancer cells. Anticancer Drugs. 2008; 191:37-44.
  38. Kirstein MN, Brundage RC, Moore MM, Williams BW, Hillman LA, Dagit JW, Fisher JE, Marker PH, Kratzke RA, Yee D. Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system. Cancer Chemother Pharmacol. 2008; 61:291-299.
  39. Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Mol Pharmacol. 2007; 726:1419-1424.
  40. Kirstein MN, Moore MM, Dudek AZ. Review of selected patents for cancer therapy targeting tumor angiogenesis. Recent Pat Anticancer Drug Discov. 2006 Jun; 1(2):153-61.
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