Publications

1. Johnson SM, Bao H, McMahon CE, Chen Y, Burr SD, Anderson AM, Madeyski-Bengtson K, Linden D, Han X, Liu J. PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein. Nat Commun. 2024 Jun 6; 15 (1):4847 Epub 2024 June 06
   View PubMed
2. Burr SD, Chen Y, Hartley CP, Zhao X, Liu J. Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor. Sci Rep. 2023 Oct 6; 13 (1):16832 Epub 2023 Oct 06
   View PubMed
3. Cremer J, Brohee L, Dupont L, Lefevre C, Peiffer R, Saarinen AM, Peulen O, Bindels L, Liu J, Colige A, Deroanne CF. Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression. Cancer Lett. 2023 Aug 10; 569:216306 Epub 2023 July 11
   View PubMed
4. Povero D, Chen Y, Johnson SM, McMahon CE, Pan M, Bao H, Petterson XT, Blake E, Lauer KP, O'Brien DR, Yu Y, Graham RP, Taner T, Han X, Razidlo GL, Liu J. HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia. J Hepatol. 2023 Aug; 79(2):378-393. Epub 2023 Apr 13.
   View PubMed
5. Campbell LE, Anderson AM, Chen Y, Johnson SM, McMahon CE, Liu J. Identification of motifs and mechanisms for lipid droplet targeting of the lipolytic inhibitors G0S2 and HIG2. J Cell Sci. 2022 Dec 15; 135 (24) Epub 2022 Dec 14
   View PubMed
6. Moran MW, Ramirez EP, Zook JD, Saarinen AM, Baravati B, Goode MR, Laloudakis V, Kaschner EK, Olson TL, Craciunescu FM, Hansen DT, Liu J, Fromme P. Biophysical characterization and a roadmap towards the NMR solution structure of G0S2, a key enzyme in non-alcoholic fatty liver disease. PLoS One. 2021; 16 (7):e0249164 Epub 2021 July 14
   View PubMed
7. Povero D, Johnson SM, Liu J. Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer. Cancer Lett. 2020 Nov 28; 493:71-79 Epub 2020 Aug 18
   View PubMed
8. Zhang X, Xie X, Heckmann BL, Saarinen AM, Gu H, Zechner R, Liu J. Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G(0)/G(1) switch gene 2 (G0S2). FASEB J. 2019 May; 33 (5):6655-6666 Epub 2019 Feb 25
   View PubMed
9. Zhang X, Saarinen AM, Campbell LE, De Filippis EA, Liu J. Regulation of Lipolytic Response and Energy Balance by Melanocortin 2 Receptor Accessory Protein (MRAP) in Adipocytes. Diabetes. 2018 Feb; 67 (2):222-234 Epub 2017 Dec 07
   View PubMed
10. Zhang X, Saarinen AM, Hitosugi T, Wang Z, Wang L, Ho TH, Liu J. Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia. Elife. 2017 Dec 19; 6
    View PubMed
11. Zhang X, Heckmann BL, Campbell LE, Liu J. G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct; 1862 (10 Pt B):1146-1154 Epub 2017 June 21
    View PubMed
12. Heckmann BL, Zhang X, Saarinen AM, Schoiswohl G, Kershaw EE, Zechner R, Liu J. Liver X receptor alpha mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression. JCI Insight. 2017 Feb 23; 2 (4):e88735
    View PubMed
13. Myers CE, Hoelzinger DB, Truong TN, Chew LA, Myles A, Chaudhuri L, Egan JB, Liu J, Gendler SJ, Cohen PA. Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet. Oncotarget. 2017 Jan 17; 8 (3):5426-5438
    View PubMed
14. Li Z, Schulze RJ, Weller SG, Krueger EW, Schott MB, Zhang X, Casey CA, Liu J, Stockli J, James DE, McNiven MA. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv. 2016 Dec; 2 (12):e1601470 Epub 2016 Dec 16
    View PubMed
15. Heckmann BL, Zhang X, Saarinen AM, Liu J. Regulation of G0/G1 Switch Gene 2 (G0S2) Protein Ubiquitination and Stability by Triglyceride Accumulation and ATGL Interaction. PLoS One. 2016; 11 (6):e0156742 Epub 2016 June 01
    View PubMed
16. Xiang B, Zhang G, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C, Smyth SS, Whiteheart SW, Li Z. Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis. Circulation. 2015 Dec 15; 132 (24):2334-44 Epub 2015 Sept 23
    View PubMed
17. Zhang X, Heckmann BL, Xie X, Saarinen AM, Liu J. Regulation of FSP27 protein stability by AMPK and HSC70. Am J Physiol Endocrinol Metab. 2014 Dec 1; 307 (11):E1047-56 Epub 2014 Oct 14
    View PubMed
18. Xie X, Langlais P, Zhang X, Heckmann BL, Saarinen AM, Mandarino LJ, Liu J. Identification of a novel phosphorylation site in adipose triglyceride lipase as a regulator of lipid droplet localization. Am J Physiol Endocrinol Metab. 2014 Jun 15; 306 (12):E1449-59 Epub 2014 May 06
    View PubMed
19. Zhang X, Xie X, Heckmann BL, Saarinen AM, Czyzyk TA, Liu J. Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes. 2014 Mar; 63 (3):934-46 Epub 2013 Nov 05
    View PubMed
20. Heckmann BL, Zhang X, Xie X, Saarinen A, Lu X, Yang X, Liu J. Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). J Biol Chem. 2014 Jan 24; 289 (4):1905-16 Epub 2013 Dec 03
    View PubMed
21. Zeng H, Liu J, Jackson MI, Zhao FQ, Yan L, Combs GF Jr. Fatty liver accompanies an increase in lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet. J Nutr. 2013 May; 143(5):627-31. Epub 2013 Mar 13.
    View PubMed
22. Heckmann BL, Zhang X, Xie X, Liu J. The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim Biophys Acta. 2013 Feb; 1831 (2):276-81 Epub 2012 Sept 29
    View PubMed
23. Yang X, Heckmann BL, Zhang X, Smas CM, Liu J. Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat proteins. Mol Endocrinol. 2013 Jan; 27 (1):116-26 Epub 2012 Nov 30
    View PubMed
24. Heckmann BL, Yang X, Zhang X, Liu J. The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes. Br J Pharmacol. 2013 Jan; 168 (1):163-71
    View PubMed
25. Zhang X, Heckmann BL, Liu J. Studying lipolysis in adipocytes by combining siRNA knockdown and adenovirus-mediated overexpression approaches. Methods Cell Biol. 2013; 116:83-105
    View PubMed
26. Langlais P, Dillon JL, Mengos A, Baluch DP, Ardebili R, Miranda DN, Xie X, Heckmann BL, Liu J, Mandarino LJ. Identification of a role for CLASP2 in insulin action. J Biol Chem. 2012 Nov 9; 287(46):39245-53. Epub 2012 Sep 19.
    View PubMed
27. Wueest S, Yang X, Liu J, Schoenle EJ, Konrad D. Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice. Am J Physiol Endocrinol Metab. 2012 Jan 1; 302(1):E153-60. Epub 2011 Oct 11.
    View PubMed
28. Yang X, Zhang X, Heckmann BL, Lu X, Liu J. Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-alpha (TNF-alpha)-induced lipolysis in adipocytes. J Biol Chem. 2011 Nov 25; 286 (47):40477-85 Epub 2011 Oct 03
    View PubMed
29. Wang H, Bell M, Sreenivasan U, Hu H, Liu J, Dalen K, Londos C, Yamaguchi T, Rizzo MA, Coleman R, Gong D, Brasaemle D, Sztalryd C. Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J Biol Chem. 2011 May 6; 286(18):15707-15. Epub 2011 Mar 09.
    View PubMed
30. Lu X, Yang X, Liu J. Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2. Cell Cycle. 2010 Jul 15; 9(14):2719-25. Epub 2010 Jul 27.
    View PubMed
31. Yang X, Lu X, Liu J. Identification of a novel splicing isoform of murine CGI-58. FEBS Lett. 2010 Mar 5; 584(5):903-10. Epub 2010 Jan 18.
    View PubMed
32. Yang X, Lu X, Lombes M, Rha GB, Chi YI, Guerin TM, Smart EJ, Liu J. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 2010 Mar 3; 11(3):194-205.
    View PubMed
33. White J, Guerin T, Swanson H, Post S, Zhu H, Gong M, Liu J, Everson WV, Li XA, Graf GA, Ballard HO, Ross SA, Smart EJ. Diabetic HDL-associated myristic acid inhibits acetylcholine-induced nitric oxide generation by preventing the association of endothelial nitric oxide synthase with calmodulin. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C295-305. Epub 2007 Oct 31.
    View PubMed
34. Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR. Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007 Dec; 18(12):4731-40. Epub 2007 Sep 26.
    View PubMed
35. Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006 Nov 15; 25(22):5284-93. Epub 2006 Nov 02.
    View PubMed
36. Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel AR. Changes in integrin expression during adipocyte differentiation. Cell Metab. 2005 Sep; 2 (3):165-77
    View PubMed
37. Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005 Apr 22; 280(16):16125-34. Epub 2005 Feb 14.
    View PubMed
38. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003 Dec; 12(6):1379-89.
    View PubMed
39. Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003 Sep 19; 278(38):36754-62. Epub 2003 Jul 02.
    View PubMed
40. Liu J, Kimura A, Baumann CA, Saltiel AR. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002 Jun; 22(11):3599-609.
    View PubMed
41. Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL. Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4. Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12):6650-5. Epub 2001 May 22.
    View PubMed
42. Liu J, Brautigan DL. Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling. J Biol Chem. 2000 Aug 25; 275(34):26074-81.
    View PubMed
43. Liu J, Brautigan DL. Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J Biol Chem. 2000 May 26; 275(21):15940-7.
    View PubMed
44. Liu J, Wu J, Oliver C, Shenolikar S, Brautigan DL. Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. Biochem J. 2000 Feb 15; 346 Pt 1:77-82.
    View PubMed
45. Jewell JE, Orwick J, Liu J, Miller KW. Functional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322. J Bacteriol. 1999 Mar; 181(5):1689-93.
    View PubMed
46. Wu J, Liu J, Thompson I, Oliver CJ, Shenolikar S, Brautigan DL. A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Lett. 1998 Nov 13; 439(1-2):185-91.
    View PubMed
47. Guo D, Liu J, Motlagh A, Jewell J, Miller KW. Efficient insertion of odd-numbered transmembrane segments of the tetracycline resistance protein requires even-numbered segments. J Biol Chem. 1996 Nov 29; 271(48):30829-34.
    View PubMed