Publications

1. Laible E, Wegner A, Knutson K, Kacmaz H, Garramone GK, Gogineni K, Matveyenko A, Linden DR, Farrugia G, Beyder A. Circadian rhythm and whole gut transit in mice. Neurogastroenterol Motil. 2024 Apr; 36 (4):e14771 Epub 2024 Feb 23
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2. Gao F, Hayashi Y, Saravanaperumal SA, Gajdos GB, Syed SA, Bhagwate A, Ye Z, Zhong J, Zhang Y, Choi EL, Kvasha SM, Kaur J, Paradise BD, Cheng L, Simone BW, Wright AM, Kellogg TA, Kendrick ML, McKenzie TJ, Sun Z, Yan H, Yu C, Bharucha AE, Linden DR, Lee JH, Ordog T. Hypoxia-inducible factor 1a stabilization restores epigenetic control of nitric oxide synthase 1 expression and reverses gastroparesis in female diabetic mice. Gastroenterology. 2023 Dec; 165 (6):1458-74
   
3. Gao F, Hayashi Y, Saravanaperumal SA, Gajdos GB, Syed SA, Bhagwate AV, Ye Z, Zhong J, Zhang Y, Choi EL, Kvasha SM, Kaur J, Paradise BD, Cheng L, Simone BW, Wright AM, Kellogg TA, Kendrick ML, McKenzie TJ, Sun Z, Yan H, Yu C, Bharucha AE, Linden DR, Lee JH, Ordog T. Hypoxia-Inducible Factor 1alpha Stabilization Restores Epigenetic Control of Nitric Oxide Synthase 1 Expression and Reverses Gastroparesis in Female Diabetic Mice. Gastroenterology. 2023 Dec; 165 (6):1458-1474 Epub 2023 Aug 18
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4. Li X, Ji S, Cipriani G, Hillestad ML, Eisenman ST, Barry MA, Nath KA, Linden DR, Wright A, AlAsfoor S, Grover M, Sha L, Hsi LC, Farrugia G. Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice. Neurogastroenterol Motil. 2023 Nov; 35 (11):e14669 Epub 2023 Sept 13
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5. Cherukuri ASS, Modi VK, Baraskar B, Sood S, Reguram R, Palvia D, Gopalakrishnan K, Damani DN, Gaddam S, Samaddar P, Katukuri N, Shivaram S, Dey S, Mitra D, Roy S, Linden DR, Beyder A, Kulkarni K, Arunachalam SP. Microwave-based dielectric properties as an electrophysiological biomarker: future perspectives. Electronics. 2023 Aug; 12 (15):3276
   
6. de Hoyos-Vega JM, Yu X, Gonzalez-Suarez AM, Chen S, Mercado-Perez A, Krueger E, Hernandez J, Fedyshyn Y, Druliner BR, Linden DR, Beyder A, Revzin A. Modeling gut neuro-epithelial connections in a novel microfluidic device. Microsyst Nanoeng. 2023; 9:144 Epub 2023 Nov 14
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7. Knutson KR, Whiteman ST, Alcaino C, Mercado-Perez A, Finholm I, Serlin HK, Bellampalli SS, Linden DR, Farrugia G, Beyder A. Intestinal enteroendocrine cells rely on ryanodine and IP(3) calcium store receptors for mechanotransduction. J Physiol. 2023 Jan; 601 (2):287-305 Epub 2022 Dec 13
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8. Truong Thuy Nguyen V, Taheri N, Choi EL, Kellogg TA, Linden DR, Hayashi Y. Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation. Cell Mol Gastroenterol Hepatol. 2023; 16 (3):369-383 Epub 2023 June 08
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9. Treichel AJ, Finholm I, Knutson KR, Alcaino C, Whiteman ST, Brown MR, Matveyenko A, Wegner A, Kacmaz H, Mercado-Perez A, Gajdos GB, Ordog T, Grover M, Szurszewski J, Linden DR, Farrugia G, Beyder A. Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity. Gastroenterology. 2022 Feb; 162 (2):535-547.e13 Epub 2021 Oct 22
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10. Zhao W, Zhang L, Ermilov LG, Colmenares Aguilar MG, Linden DR, Eisenman ST, Romero MF, Farrugia G, Sha L, Gibbons SJ. Bicarbonate ion transport by the electrogenic Na(+) /HCO3(-) cotransporter, NBCe1, is required for normal electrical slow-wave activity in mouse small intestine. Neurogastroenterol Motil. 2021 Sep; 33 (9):e14149 Epub 2021 Apr 10
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11. Bartman CM, Stelzig KE, Linden DR, Prakash YS, Chiarella SE. Passive siRNA transfection method for gene knockdown in air-liquid interface airway epithelial cell cultures. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1; 321 (1):L280-L286 Epub 2021 May 26
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12. Kacmaz H, Alto A, Knutson K, Linden DR, Gibbons SJ, Farrugia G, Beyder A. A simple automated approach to measure mouse whole gut transit. Neurogastroenterol Motil. 2021 Feb; 33 (2):e13994 Epub 2020 Sept 30
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13. Puthanmadhom Narayanan S, Linden DR, Peters SA, Desai A, Kuwelker S, O'Brien D, Smyrk TJ, Graham RP, Grover M, Bharucha AE. Duodenal mucosal secretory disturbances in functional dyspepsia. Neurogastroenterol Motil. 2021 Jan; 33 (1):e13955 Epub 2020 Aug 09
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14. Hayashi Y, Asuzu DT, Bardsley MR, Gajdos GB, Kvasha SM, Linden DR, Nagy RA, Saravanaperumal SA, Syed SA, Toyomasu Y, Yan H, Chini EN, Gibbons SJ, Kellogg TA, Khazaie K, Kuro-O M, Machado Espindola Netto J, Singh MP, Tidball JG, Wehling-Henricks M, Farrugia G, Ordog T. Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. Cell Mol Gastroenterol Hepatol. 2021; 11 (1):117-145 Epub 2020 Aug 07
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15. Bhattarai Y, Jie S, Linden DR, Ghatak S, Mars RAT, Williams BB, Pu M, Sonnenburg JL, Fischbach MA, Farrugia G, Sha L, Kashyap PC. Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease. iScience. 2020 Dec 18; 23 (12):101798 Epub 2020 Nov 13
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16. Melo CGS, Nicolai EN, Alcaino C, Cassmann TJ, Whiteman ST, Wright AM, Miller KE, Gibbons SJ, Beyder A, Linden DR. Identification of intrinsic primary afferent neurons in mouse jejunum. Neurogastroenterol Motil. 2020 Dec; 32 (12):e13989 Epub 2020 Sept 28
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17. Bartman CM, Schiliro M, Helan M, Prakash YS, Linden D, Pabelick C. Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J. 2020 Sep; 34 (9):12991-13004 Epub 2020 Aug 10
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18. Nyavor Y, Brands CR, May G, Kuther S, Nicholson J, Tiger K, Tesnohlidek A, Yasuda A, Starks K, Litvinenko D, Linden DR, Bhattarai Y, Kashyap PC, Forney LJ, Balemba OB. High-fat diet-induced alterations to gut microbiota and gut-derived lipoteichoic acid contributes to the development of enteric neuropathy. Neurogastroenterol Motil. 2020 Jul; 32 (7):e13838 Epub 2020 Mar 13
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19. Cipriani G, Terhaar ML, Eisenman ST, Ji S, Linden DR, Wright AM, Sha L, Ordog T, Szurszewski JH, Gibbons SJ, Farrugia G. Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons. Cell Mol Gastroenterol Hepatol 2019; 7 (3):689-691.e4 Epub 2019 Jan 31
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20. Saadalla A, Lima MM, Tsai F, Osman A, Singh MP, Linden DR, Dennis KL, Haeryfar SMM, Gurish MF, Gounari F, Khazaie K. Cell Intrinsic Deregulated ss-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer. Front Immunol. 2019; 10:2777 Epub 2019 Dec 03
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21. Bianco F, Eisenman ST, Colmenares Aguilar MG, Bonora E, Clavenzani P, Linden DR, De Giorgio R, Farrugia G, Gibbons SJ. Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine. Neurogastroenterol Motil. 2018 Sep; 30 (9):e13429 Epub 2018 Aug 01
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22. Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, Li JH, Leiter AB, Szurszewski JH, Farrugia G, Beyder A. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci U S A. 2018 Aug 7; 115 (32):E7632-E7641 Epub 2018 July 23
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23. Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 Jun 13; 23 (6):775-785.e5
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24. Cipriani G, Gibbons SJ, Miller KE, Yang DS, Terhaar ML, Eisenman ST, Ordog T, Linden DR, Gajdos GB, Szurszewski JH, Farrugia G. Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice. Gastroenterology. 2018 Jun; 154 (8):2122-2136.e12 Epub 2018 Mar 06
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25. Miller KE, Bajzer Z, Hein SS, Phillips JE, Syed S, Wright AM, Cipriani G, Gibbons SJ, Szurszewski JH, Farrugia G, Ordog T, Linden DR. High temporal resolution gastric emptying breath tests in mice. Neurogastroenterol Motil. 2018 Mar 25; e13333 [Epub ahead of print]
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26. Saravanaperumal SA, Gibbons SJ, Malysz J, Sha L, Linden DR, Szurszewski JH, Farrugia G. Extracellular Cl(-) regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum. Exp Physiol. 2018 Jan 1; 103 (1):40-57 Epub 2017 Nov 02
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27. Strege PR, Knutson K, Eggers SJ, Li JH, Wang F, Linden D, Szurszewski JH, Milescu L, Leiter AB, Farrugia G, Beyder A. Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. Sci Rep. 2017 Nov 15; 7 (1):15650
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28. Jean A, Laurent L, Delaunay S, Doly S, Dusticier N, Linden D, Neve R, Maroteaux L, Nieoullon A, Compan V. Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress. Cell Rep. 2017 Oct 24; 21 (4):901-909
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29. Hayashi Y, Toyomasu Y, Saravanaperumal SA, Bardsley MR, Smestad JA, Lorincz A, Eisenman ST, Cipriani G, Nelson Holte MH, Al Khazal FJ, Syed SA, Gajdos GB, Choi KM, Stoltz GJ, Miller KE, Kendrick ML, Rubin BP, Gibbons SJ, Bharucha AE, Linden DR, Maher LJ 3rd, Farrugia G, Ordog T. Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying. Gastroenterology. 2017 Aug; 153 (2):521-535.e20 Epub 2017 Apr 21
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30. Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, Farrugia G, Kashyap PC. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1; 313 (1):G80-G87 Epub 2017 Apr 13
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31. Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function. Am J Gastroenterol. 2017 Jun; 112 (6):913-923 Epub 2017 Mar 21
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32. Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, Leiter AB, Farrugia G, Beyder A. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017 Jan 1; 595 (1):79-91 Epub 2016 Aug 13
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33. Chen J, Toyomasu Y, Hayashi Y, Linden DR, Szurszewski JH, Nelson H, Farrugia G, Kashyap PC, Chia N, Ordog T. Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction. Genome Med. 2016 Oct 3; 8 (1):103 Epub 2016 Oct 03
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34. Reigstad CS, Linden DR, Szurszewski JH, Sonnenburg JL, Farrugia G, Kashyap PC. Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes. Neurogastroenterol Motil. 2016 Sep; 28 (9):1443-8 Epub 2016 Apr 12
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35. Camilleri M, Linden DR. Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2 (4):412-428
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36. Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G. Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2 (4):454-467 Epub 2016 Apr 23
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37. Panizzon CPDNB, Zanoni JN, Hermes-Uliana C, Trevizan AR, Sehaber CC, Pereira RVF, Linden DR, Neto MHM. Desired and side effects of the supplementation with l-glutamine and l-glutathione in enteric glia of diabetic rats. Acta Histochem. 2016 Jul; 118 (6):625-631 Epub 2016 July 26
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38. Lazaridis KN, Schahl KA, Cousin MA, Babovic-Vuksanovic D, Riegert-Johnson DL, Gavrilova RH, McAllister TM, Lindor NM, Abraham RS, Ackerman MJ, Pichurin PN, Deyle DR, Gavrilov DK, Hand JL, Klee EW, Stephens MC, Wick MJ, Atkinson EJ, Linden DR, Ferber MJ, Wieben ED, Farrugia G, Individualized Medicine Clinic Members. Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience. Mayo Clin Proc. 2016 Mar; 91(3):297-307.
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39. Pereira RV, Linden DR, Miranda-Neto MH, Zanoni JN. Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine. An Acad Bras Cienc. 2016; 88 Suppl 1:609-22
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40. Cipriani G, Gibbons SJ, Verhulst PJ, Choi KM, Eisenman ST, Hein SS, Ordog T, Linden DR, Szurszewski JH, Farrugia G. Diabetic Csf1(op/op) mice lacking macrophages are protected against the development of delayed gastric emptying. Cell Mol Gastroenterol Hepatol. 2016 Jan 1; 2 (1):40-47
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41. Fracaro L, Frez FC, Silva BC, Vicentini GE, de Souza SR, Martins HA, Linden DR, Guarnier FA, Zanoni JN. Walker 256 tumor-bearing rats demonstrate altered interstitial cells of Cajal. Effects on ICC in the Walker 256 tumor model. Neurogastroenterol Motil. 2016 Jan; 28 (1):101-15 Epub 2015 Nov 03
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42. Strege PR, Bernard CE, Mazzone A, Linden DR, Beyder A, Gibbons SJ, Farrugia G. A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2. Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1; 309 (9):G743-9 Epub 2015 Sept 10
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43. Bajzer Z, Gibbons SJ, Coleman HD, Linden DR, Farrugia G. A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1; 309 (3):G162-70 Epub 2015 June 04
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44. Cipriani G, Gibbons SJ, Saravanaperumal SA, Malysz J, Sha L, Szurszewski JH, Linden DR, Evangelista S, Faussone-Pellegrini MS, Vannucchi MG, Farrugia G. Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide. Neurogastroenterol Motil. 2015 Jul; 27 (7):997-1009 Epub 2015 Apr 30
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45. Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J. 2015 Apr; 29 (4):1395-403 Epub 2014 Dec 30
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46. Brierley SM, Linden DR. Neuroplasticity and dysfunction after gastrointestinal inflammation. Nat Rev Gastroenterol Hepatol. 2014 Oct; 11 (10):611-27 Epub 2014 July 08
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47. Sha L, Linden DR, Farrugia G, Szurszewski JH. Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle. J Physiol. 2014 Mar 1; 592 (5):1077-89 Epub 2013 Dec 23
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48. Linden DR. Hydrogen sulfide signaling in the gastrointestinal tract. Antioxid Redox Signal. 2014 Feb 10; 20 (5):818-30 Epub 2013 May 19
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49. Grover M, Camilleri M, Smith K, Linden DR, Farrugia G. On the fiftieth anniversary. Postinfectious irritable bowel syndrome: mechanisms related to pathogens. Neurogastroenterol Motil. 2014 Feb; 26 (2):156-67
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50. Ferreira PE, Lopes CR, Alves AM, Alves EP, Linden DR, Zanoni JN, Buttow NC. Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats. World J Gastroenterol. 2013 Oct 14; 19(38):6416-26.
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51. Sha L, Linden DR, Farrugia G, Szurszewski JH. Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion. J Neurosci. 2013 Jul 31; 33 (31):12638-46
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52. Linden DR. Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis. Neurosci Lett. 2013 Jun 17; 545:91-5 Epub 2013 Apr 28
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53. Creedon CT, Verhulst PJ, Choi KM, Mason JE, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test. J Vis Exp. 2013 Mar 23; (73):e50301
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54. Linden DR. Colitis is associated with a loss of intestinofugal neurons. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15; 303 (10):G1096-104 Epub 2012 Sept 20
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55. Linden DR. Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 1; 303 (9):G1067-75 Epub 2012 Sept 06
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56. Kasparek MS, Linden DR, Farrugia G, Sarr MG. Hydrogen sulfide modulates contractile function in rat jejunum. J Surg Res. 2012 Jun 15; 175 (2):234-42 Epub 2011 Apr 22
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57. Linden DR, Furne J, Stoltz GJ, Abdel-Rehim MS, Levitt MD, Szurszewski JH. Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS. Br J Pharmacol. 2012 Apr; 165 (7):2178-90
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58. Asuzu DT, Hayashi Y, Izbeki F, Popko LN, Young DL, Bardsley MR, Lorincz A, Kuro-O M, Linden DR, Farrugia G, Ordog T. Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil. 2011 Jul; 23 (7):e309-23 Epub 2011 May 24
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59. Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G. Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300 (6):G1105-14 Epub 2011 Mar 10
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60. Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ordog T, Gibbons SJ, Farrugia G. Altered expression of Ano1 variants in human diabetic gastroparesis. J Biol Chem. 2011 Apr 15; 286 (15):13393-403 Epub 2011 Feb 24
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61. Nagao M, Linden DR, Duenes JA, Sarr MG. Mechanisms of action of the gasotransmitter hydrogen sulfide in modulating contractile activity of longitudinal muscle of rat ileum. J Gastrointest Surg. 2011 Jan; 15(1):12-22. Epub 2010 Nov 17.
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62. Sha L, Farrugia G, Linden DR, Szurszewski JH. The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent. FASEB J. 2010 Oct; 24 (10):3840-9 Epub 2010 June 11
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63. Izbeki F, Asuzu DT, Lorincz A, Bardsley MR, Popko LN, Choi KM, Young DL, Hayashi Y, Linden DR, Kuro-o M, Farrugia G, Ordog T. Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol. 2010 Aug 15; 588 (Pt 16):3101-17 Epub 2010 June 25
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64. Kashyap PC, Choi KM, Dutta N, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. Carbon monoxide reverses diabetic gastroparesis in NOD mice. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298 (6):G1013-9 Epub 2010 Apr 08
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65. Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology. 2010 Jun; 138 (7):2399-409, 2409.e1 Epub 2010 Feb 20
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66. Linden DR, Levitt MD, Farrugia G, Szurszewski JH. Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxid Redox Signal. 2010 May 1; 12 (9):1135-46
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67. Bharucha AE, Linden DR. Linaclotide - a secretagogue and antihyperalgesic agent - what next? Neurogastroenterol Motil. 2010 Mar; 22 (3):227-31
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68. Bertrand PP, Linden DR. Getting a handle on cholera and the circuits controlling intestinal motility. Front Neurosci. 2010; 4:197. Epub 2010 Nov 25.
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69. Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA. Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut. 2009 Oct; 58(10):1333-41. Epub 2009 Mar 25.
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70. Bernard CE, Gibbons SJ, Gomez-Pinilla PJ, Lurken MS, Schmalz PF, Roeder JL, Linden D, Cima RR, Dozois EJ, Larson DW, Camilleri M, Zinsmeister AR, Pozo MJ, Hicks GA, Farrugia G. Effect of age on the enteric nervous system of the human colon. Neurogastroenterol Motil. 2009 Jul; 21 (7):746-e46 Epub 2009 Feb 08
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71. Linden DR, White SL, Brooks EM, Mawe GM. Novel promoter and alternate transcription start site of the human serotonin reuptake transporter in intestinal mucosa. Neurogastroenterol Motil. 2009 May; 21(5):534-41, e10-1. Epub 2009 Feb 13.
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72. Linden DR, Sha L, Mazzone A, Stoltz GJ, Bernard CE, Furne JK, Levitt MD, Farrugia G, Szurszewski JH. Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. J Neurochem. 2008 Aug; 106 (4):1577-85 Epub 2008 May 29
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73. Kasparek MS, Linden DR, Kreis ME, Sarr MG. Gasotransmitters in the gastrointestinal tract. Surgery. 2008 Apr; 143 (4):455-9 Epub 2008 Jan 30
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74. Krauter EM, Strong DS, Brooks EM, Linden DR, Sharkey KA, Mawe GM. Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig. Neurogastroenterol Motil. 2007 Dec; 19(12):990-1000. Epub 2007 Aug 17.
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75. Krauter EM, Linden DR, Sharkey KA, Mawe GM. Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation. J Physiol. 2007 Jun 1; 581(Pt 2):787-800. Epub 2007 Mar 15.
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76. Lomax AE, Linden DR, Mawe GM, Sharkey KA. Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits. Auton Neurosci. 2006 Jun 30; 126-127:250-7. Epub 2006 Apr 17.
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77. Linden DR, Couvrette JM, Ciolino A, McQuoid C, Blaszyk H, Sharkey KA, Mawe GM. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterol Motil. 2005 Oct; 17(5):751-60.
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78. Linden DR, Foley KF, McQuoid C, Simpson J, Sharkey KA, Mawe GM. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastoenerol Motil. 2005 Aug; 17(4):565-74.
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79. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 2004 Jun; 126(7):1657-64.
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80. Linden DR, Sharkey KA, Ho W, Mawe GM. Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurons in the inflamed guinea pig distal colon. J Physiol. 2004; 557:191-205.
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81. O'Hara JR, Ho W, Linden DR, Mawe GM Sharkey KA. Enteroendocrine cells and serotonin availability are altered in the mucosa of guinea pigs with TNBS ileitis. Am J Physiol Gastrointest Liver Physiol. 2004; 287:G998-G1007.
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82. Linden DR, Sharkey KA, Mawe GM. Enhanced neuronal excitability in the myenteric plexus of the inflamed guinea pig distal colon. J Physiol. 2003; 547:589-601.
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83. Linden DR. Colitis: It's not just for the colon anymore. Brit J Pharmacol. 2003; 139:185-6.
    
84. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2003; 285:G207-16.
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85. Linden DR, El-Fakahany EE. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. Eur J Clin Pharmacol. 2002; 436:53-6.
    
86. Linden DR, El-Fakahany EE. Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells. Neurochem Res. 2002; 27:441-9.
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87. Linden DR, Manning BP, Bunnett NW, Mawe GM. Agonists of proteinase activated receptor 2 (PAR2) excite guinea pig ileal myenteric neurons. Eur J Clin Pharmacol. 2001; 431:311-4.
    
88. Linden DR, Chell MJ, El-Fakahany EE, Seybold VS. Neurokinin3 receptors couple to the activation of neuronal nitric oxide synthase in stably transfected Chinese hamster ovary cells. J Pharmacol Exp Ther. 2000; 293:559-68.
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