Faculty

Allan S. Jaffe, M.D.

Publications

Pickering JW, Devlin G, Body R, Aldous S, Jaffe AS, Apple FS, Mills N, Troughton RW, Kavsak P, Peacock WF, Cullen L, Lord SJ, Muller C, Joyce L, Frampton C, Lacey CJ, Richards AM, Pitama S, Than M. Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative. BMJ Open. 2024 Jun 13; 14 (6):e083752 Epub 2024 June 13
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Churchill RA, Gochanour BR, Scott CG, Vasile VC, Rodeheffer RJ, Meeusen JW, Jaffe AS. Association of cardiac biomarkers with long-term cardiovascular events in a community cohort. Biomarkers. 2024 Jun; 29 (4):161-170 Epub 2024 Apr 26
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Jaffe AS, Donato LJ. DPP3 in Cardiogenic Shock. Clin Chem. 2024 May 29 [Epub ahead of print]
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Thygesen K, Jaffe AS. A call for universal definition of myocardial infarction after cardiac surgery. Eur J Cardiothorac Surg 2024 Mar 29; 65 (4)
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Knott JD, Ola O, De Michieli L, Akula A, Yang EH, Gharacholou SM, Slusser J, Lewis B, Mehta RA, Gulati R, Sandoval Y, Jaffe AS. High Baseline High-Sensitivity Cardiac Troponin T Concentrations and Risk of Index Acute Myocardial Infarction. Mayo Clin Proc. 2024 Mar 15 [Epub ahead of print]
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Wu AHB, Jaffe AS, Peacock WF, Kavsak P, Greene D, Christenson RH. The Role of Artificial Intelligence for Providing Scientific Content for Laboratory Medicine. J Appl Lab Med. 2024 Mar 1; 9 (2):386-393
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Kavsak PA, Clark L, Arnoldo S, Lou A, Shea JL, Eintracht S, Lyon AW, Bhayana V, Thorlacius L, Raizman JE, Tsui A, Djiana R, Chen M, Huang Y, Haider A, Booth RA, McCudden C, Yip PM, Beriault D, Blank D, Fung AWS, Taher J, St-Cyr J, Sharif S, Belley-Cote E, Abramson BL, Friedman SM, Cox JL, Sivilotti MLA, Chen-Tournoux A, McLaren J, Mak S, Thiruganasambandamoorthy V, Scheuermeyer F, Humphries KH, Worster A, Ko D, Aakre KM, Mills NL, Jaffe AS. Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile. Clin Biochem. 2024 Mar; 125:110731 Epub 2024 Feb 13
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Lobo R, De Michieli L, Spears GM, Theel ES, Donato LJ, Wockenfus AM, Kelley BR, Jaffe AS. Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection. Clin Biochem. 2024 Mar; 125:110732 Epub 2024 Feb 15
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Coverdell TC, Sampson M, Zubiran R, Wolska A, Donato LJ, Meeusen JW, Jaffe AS, Remaley AT. An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation. Lipids Health Dis. 2024 Feb 8; 23 (1):43 Epub 2024 Feb 08
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Breen TJ, Raphael CE, Ingraham B, Lane C, Huxley S, Roger VL, Jaffe A, Lewis B, Sandoval YB, Prasad A, Rihal CS, Gulati R, Singh M. Incidence and outcomes of high bleeding risk patients with type 1 and type 2 myocardial infarction in a community-based cohort: Application of the Academic Research Consortium High Bleeding Risk Criteria. Int J Cardiol. 2024 Feb 1; 396:131565 Epub 2023 Oct 30
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De Michieli L, Cipriani A, Iliceto S, Dispenzieri A, Jaffe AS. Cardiac Troponin in Patients With Light Chain and Transthyretin Cardiac Amyloidosis: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol. 2024 Feb; 6 (1):1-15 Epub 2024 Feb 20
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Jaffe AS, Meex SJR, Saenger AK, van Wijk XMR. A special series on cardiac troponin: an analytical and clinical matter. Journal of Laboratory and Precision Medicine. 2024; 9:11
Jaffe AS, Mills NL, Mueller C. Peri-procedural myocardial infarction/injury after percutaneous coronary intervention. Eur Heart J Acute Cardiovasc Care. 2023 Dec 21; 12 (12):878-880
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Salas J, Wang W, Schnurr PP, Cohen BE, Freedland KE, Jaffe AS, Lustman PJ, Friedman M, Scherrer JF. Severity of posttraumatic stress disorder, type 2 diabetes outcomes and all-cause mortality: A retrospective cohort study. J Psychosom Res. 2023 Dec; 175:111510 Epub 2023 Sept 29
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Beunders R, Donato LJ, van Groenendael R, Arlt B, Carvalho-Wodarz C, Schulte J, Coolen AC, Lieske JC, Meeusen JW, Jaffe AS, Pickkers P. Assessing GFR With Proenkephalin. Kidney Int Rep. 2023 Nov; 8 (11):2345-2355 Epub 2023 Aug 19
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Ola O, Akula A, De Michieli L, Knott JD, Lobo R, Mehta RA, Hodge DO, Gulati R, Sandoval Y, Jaffe AS. Use of the HEAR Score for 30-Day Risk-Stratification in Emergency Department Patients. Am J Med. 2023 Sep; 136 (9):918-926.e5 Epub 2023 May 24
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Hammarsten O, Warner JV, Lam L, Kavsak P, Lindahl B, Aakre KM, Collinson P, Jaffe AS, Saenger AK, Body R, Mills NL, Omland T, Ordonez-Llanos J, Apple FS. Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers. Clin Chem Lab Med. 2023 Jul 26; 61 (8):1411-1419 Epub 2023 Mar 24
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Jaffe AS, Body R, Mills NL, Aakre KM, Collinson PO, Saenger A, Hammarsten O, Wereski R, Omland T, Sandoval Y, Ordonez-Llanos J, Apple FS, IFCC Committee on Cardiac Bio-Markers. Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week. J Am Coll Cardiol. 2023 Jul 4; 82 (1):60-69
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Kavsak PA, Clark L, Arnoldo S, Lou A, Shea JL, Eintracht S, Lyon AW, Bhayana V, Thorlacius L, Raizman JE, Tsui AKY, Djiana R, Chen M, Huang Y, Booth RA, McCudden C, Lavoie J, Beriault DR, Blank DW, Fung AWS, Hoffman B, Taher J, St-Cyr J, Yip PM, Belley-Cote EP, Abramson BL, Borgundvaag B, Friedman SM, Mak S, McLaren J, Steinhart B, Udell JA, Wijeysundera HC, Atkinson P, Campbell SG, Chandra K, Cox JL, Mulvagh S, Quraishi AU, Chen-Tournoux A, Clark G, Segal E, Suskin N, Johri AM, Sivilotti MLA, Garuba H, Thiruganasambandamoorthy V, Robinson S, Scheuermeyer F, Humphries KH, Than M, Pickering JW, Worster A, Mills NL, Devereaux PJ, Jaffe AS. Analytic Result Variation for High-Sensitivity Cardiac Troponin: Interpretation and Consequences. Can J Cardiol. 2023 Jul; 39 (7):947-951 Epub 2023 Apr 23
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Knott JD, De Michieli L, Ola O, Akula A, Mehta RA, Hodge DO, Tak T, Cagin C, Gulati R, Jaffe AS, Sandoval Y. Diagnosis and Prognosis of Type 2 Myocardial Infarction Using Objective Evidence of Acute Myocardial Ischemia: A Validation Study. Am J Med. 2023 Jul; 136 (7):687-693.e2 Epub 2023 Apr 07
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Jaffe AS. Novel initiatives are always welcome. Eur Heart J Acute Cardiovasc Care. 2023 Jun 2; 12 (6):372-373
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Collinson P, Aakre KM, Saenger A, Body R, Hammarsten O, Jaffe AS, Kavsak P, Omland T, Ordonez-Lianos J, Karon B, Apple FS. Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB). Clin Chem Lab Med. 2023 May 25; 61 (6):989-998 Epub 2023 Jan 16
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Duceppe E, Borges FK, Conen D, Tiboni M, Chan MTV, Patel A, Sessler DI, Kavsak PA, Ofori S, Srinathan S, Pearse R, Jaffe AS, Heels-Ansdell D, Garg AX, Pettit S, Sapsford R, Devereaux PJ. Association of Preoperative Growth Differentiation Factor-15 Concentrations and Postoperative Cardiovascular Events after Major Noncardiac Surgery. Anesthesiology. 2023 May 1; 138 (5):508-522
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Borges FK, Duceppe E, Heels-Ansdell D, Patel A, Sessler DI, Tandon V, Chan M, Pearse R, Srinathan S, Garg AX, Sapsford RJ, Ofori SN, Marcucci M, Kavsak PA, Pettit S, Spence J, Belley-Cote E, McGillion M, Whitlock R, Lamy A, Conen D, Thomas S, Mueller C, Jaffe AS, Devereaux PJ. High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy. Clin Chem. 2023 Apr 28; 69 (5):492-499
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Miranda WR, Jain CC, Borlaug BA, Jaffe AS, Connolly HM, Burchill LJ, Egbe AC. Exercise Capacity, NT-proBNP, and Exercise Hemodynamics in Adults Post-Fontan. J Am Coll Cardiol. 2023 Apr 25; 81 (16):1590-1600
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De Michieli L, Jaffe AS, Sandoval Y. Use and Prognostic Implications of Cardiac Troponin in COVID-19. Heart Fail Clin. 2023 Apr; 19 (2):163-176
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Burczak DR, Newman DB, Jaffe AS, Ackerman MJ, Ommen SR, Geske JB. High-Sensitivity Cardiac Troponin T Elevation in Hypertrophic Cardiomyopathy Is Associated With Ventricular Arrhythmias. Mayo Clin Proc. 2023 Mar; 98 (3):410-418
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Lobo R, White RD, Donato LJ, Wockenfus AM, Kelley BR, Melduni RM, Jaffe AS. Absence of significant myocardial injury following elective direct current cardioversion for atrial fibrillation. Heart Rhythm O2. 2023 Mar; 4 (3):180-186 Epub 2022 Dec 21
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De Michieli L, Knott JD, Attia ZI, Ola O, Mehta RA, Akula A, Hodge DO, Gulati R, Friedman PA, Jaffe AS, Sandoval Y. Artificial intelligence-augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T. Eur Heart J Acute Cardiovasc Care. 2023 Feb 09; 12(2):106-114.
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Lobo R, Lieske JC, Donato LJ, Hickson LJ, Hodge DO, Chapman A, Schwartz GL, Jaffe AS. Measuring copeptin, a surrogate for vasopressin in patients with hypertension - Can it identify those who are volume Responsive? Clin Biochem. 2023 Feb; 112:48-52. Epub 2022 Dec 05.
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Jaffe AS. An interview with Allan S Jaffe: a life researching cardiac biomarkers. Biomark Med 2023 Feb; 17 (4):181-187 Epub 2023 Apr 21
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McCarthy C, Li S, Wang TY, Raber I, Sandoval Y, Smilowitz NR, Wasfy JH, Pandey A, de Lemos JA, Kontos MC, Apple FS, Daniels LB, Newby LK, Jaffe AS, Januzzi JL Jr. Implementation of High-Sensitivity Cardiac Troponin Assays in the United States. J Am Coll Cardiol. 2023 Jan 24; 81 (3):207-219 Epub 2022 Oct 31
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Boone S, Peacock WF, Wu AHB, Jaffe A, Christenson RH, Ettner FM, Dadkhah S. Concentration of hs-Troponin in small cohort of transgender patients. Clin Chim Acta. 2023 Jan 15; 539:66-69 Epub 2022 Dec 08
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Lobo R, Jaffe AS. Sex-specific thresholds for cardiac biomarkers-we need to move forward. Reviews in Cardiovascular Medicine. 2023; 24 (3):A41
Sampson M, Wolska A, Cole J, Zubiran R, Otvos JD, Meeusen JW, Donato LJ, Jaffe AS, Remaley AT. Accuracy and Clinical Impact of Estimating Low-Density Lipoprotein-Cholesterol at High and Low Levels by Different Equations. Biomedicines. 2022 Dec 6; 10 (12) Epub 2022 Dec 06
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De Michieli L, Lobo R, Babuin L, Melduni RM, Iliceto S, Prasad A, Sandoval Y, Jaffe AS. Structural Cardiac Abnormalities in Patients with Atrial Fibrillation/Flutter and Myocardial Injury. Am J Med. 2022 Dec; 135 (12):1488-1496.e5 Epub 2022 July 10
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Burczak D, Newman DB, Jaffe AS, Ackerman MJ, Ommen SR, Geske JB. High Sensitivity Troponin T Elevation in Hypertrophic Cardiomyopathy is Associated with Ventricular Arrhythmias. Mayo Clinic Proceedings In Press. 2022.
Jaffe AS, Mills NL, Mueller C, Study Group on Biomarkers of the ESC Association for Acute CardioVascular Care. The retirement of CKMB. Eur Heart J Acute Cardiovasc Care. 2022 Nov 2; 11 (10):784-785
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Sandoval Y, Apple FS, Mahler SA, Body R, Collinson PO, Jaffe AS, International Federation of Clinical Chemistry and Laboratory Medicine Committee on the Clinical Application of Cardiac Biomarkers. High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain. Circulation. 2022 Aug 16; 146(7):569-581. Epub 2022 Jul 01.
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Alpert JS, Jaffe AS, White HD, Thygesen KA. Type 1, Type 2 Myocardial Infarction and Non-Ischemic Myocardial Injury-Opinion from the Front Lines. Am J Med. 2022 Aug; 135(8):935-938. Epub 2022 Mar 25.
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De Michieli L, Jaffe AS, Sandoval Y. Use and Prognostic Implications of Cardiac Troponin in COVID-19. Cardiol Clin. 2022 Aug; 40(3):287-300. Epub 2022 Mar 31.
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Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022 Aug 01; 33(5):376-384. Epub 2022 Mar 08.
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Aldana-Bitar J, Ramirez NR, Jaffe AS, Manubolu VS, Verghese D, Hussein L, Anderson LR, Budoff MJ, Karlsberg RP. Serial Changes in Troponin I in COVID-19 Vaccine-Associated Myocarditis. Cardiol Res. 2022 Aug; 13(4):250-254. Epub 2022 Aug 15.
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Aakre KM, Saenger AK, Body R, Collinson P, Hammarsten O, Jaffe AS, Kavsak P, Omland T, Ordonez-Lianos J, Apple FS. Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. Clin Chem. 2022 Jul 27; 68(8):1022-1030.
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Knott JD, Ola O, De Michieli L, Akula A, Mehta RA, Dworak M, Crockford E, Lobo R, Rastas N, Karturi S, Wohlrab S, Hodge DO, Grube E, Tak T, Cagin C, Gulati R, Jaffe AS, Sandoval Y. Major adverse cardiovascular events after diagnosis of myocardial injury and types 1 and 2 myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2022 Jul 21; 11(7):546-557.
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Wang A, Sandoval Y, Apple FS, Homme J, Jaffe AS, IFCC Committee on Clinical Applications of Cardiac Bio-Markers. The Need to Develop Clinical Guidance for the Use of High-Sensitivity Cardiac Troponin in Pediatric and Neonatal Patients. Clin Chem. 2022 Jul 03; 68(7):884-886.
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Mair J, Jaffe A, Lindahl B, Mills N, Mockel M, Cullen L, Giannitsis E, Hammarsten O, Huber K, Krychtiuk K, Mueller C, Thygesen K. The clinical approach to diagnosing peri-procedural myocardial infarction after percutaneous coronary interventions according to the fourth universal definition of myocardial infarction - from the study group on biomarkers of the European Society of Cardiology (ESC) Association for Acute CardioVascular Care (ACVC). Biomarkers. 2022 Jul; 27 (5):407-417 Epub 2022 May 26
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Ramos P, Jenkins SM, Donato LJ, Hartman SJ, Saenger A, Baumann NA, Block DR, Jaffe AS, Meeusen JW. The Biological Variability of Plasma Ceramides in Healthy Subjects. J Appl Lab Med. 2022 Jun 30; 7(4):863-870.
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Sandoval Y, Lewis BR, Mehta RA, Ola O, Knott JD, De Michieli L, Akula A, Lobo R, Yang EH, Gharacholou SM, Dworak M, Crockford E, Rastas N, Grube E, Karturi S, Wohlrab S, Hodge DO, Tak T, Cagin C, Gulati R, Jaffe AS. Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation. Circulation. 2022 Jun 7; 145 (23):1708-1719 Epub 2022 May 10
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Mair J, Giannitsis E, Mills NL, Mueller C, Study Group on Biomarkers of the European Society of Cardiology Association for Acute CardioVascular Care. How to deal with unexpected cardiac troponin results. Eur Heart J Acute Cardiovasc Care. 2022 Jun 7; 11 (4):e1-e3
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Drenger B, Jaffe AS, Gilon D, Mosseri M. Professor Giora Landesberg, MD, DSc, MBA, 1954-2021: A Physician and Research Pioneer in Perioperative Myocardial Infarction. J Cardiothorac Vasc Anesth. 2022 May; 36(5):1254-1257. Epub 2021 Dec 14.
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Vallabhajosyula S, Kumar V, Sundaragiri PR, Cheungpasitporn W, Miller PE, Harsha Patlolla S, Gersh BJ, Lerman A, Jaffe AS, Shah ND, Holmes DR Jr, Bell MR, Barsness GW. Management and Outcomes of Acute Myocardial Infarction-Cardiogenic Shock in Uninsured Compared With Privately Insured Individuals. Circ Heart Fail. 2022 May; 15 (5):e008991 Epub 2022 Mar 04
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Akhiyat N, Vasile V, Ahmad A, Sara JD, Nardi V, Lerman LO, Jaffe A, Lerman A. Plasma Ceramide Levels Are Elevated in Patients With Early Coronary Atherosclerosis and Endothelial Dysfunction. J Am Heart Assoc. 2022 Apr 5; 11 (7):e022852 Epub 2022 Mar 18
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Verghese D, Patlolla SH, Cheungpasitporn W, Doshi R, Miller VM, Jentzer JC, Jaffe AS, Holmes DR, Vallabhajosyula S. Sex disparities in management and outcomes of cardiac arrest complicating acute myocardial infarction in the United States. Resuscitation. 2022 Mar; 172:92-100. Epub 2022 Jan 31.
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Vallabhajosyula S, Bhopalwala HM, Sundaragiri PR, Dewaswala N, Cheungpasitporn W, Doshi R, Prasad A, Sandhu GS, Jaffe AS, Bell MR, Holmes DR Jr. Cardiogenic shock complicating non-ST-segment elevation myocardial infarction: An 18-year study. Am Heart J. 2022 Feb; 244:54-65 Epub 2021 Nov 11
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Wang AP, Homme JL, Qureshi MY, Sandoval Y, Jaffe AS. High-Sensitivity Troponin T Testing for Pediatric Patients in the Emergency Department. Pediatr Cardiol. 2022 Feb; 43 (2):350-359 Epub 2021 Nov 17
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Zheng W, Chilazi M, Park J, Sathiyakumar V, Donato LJ, Meeusen JW, Lazo M, Guallar E, Kulkarni KR, Jaffe AS, Santos RD, Toth PP, Jones SR, Martin SS. Assessing the Accuracy of Estimated Lipoprotein(a) Cholesterol and Lipoprotein(a)-Free Low-Density Lipoprotein Cholesterol. J Am Heart Assoc. 2022 Jan 18; 11 (2):e023136 Epub 2022 Jan 13
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Sampson M, Wolska A, Meeusen JW, Donato LJ, Jaffe AS, Remaley AT. Identification of Dysbetalipoproteinemia by an Enhanced Sampson-NIH Equation for Very Low-Density Lipoprotein-Cholesterol. Front Genet. 2022; 13:935257. Epub 2022 Jul 14.
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Aldana-Bitar J, Ramirez NR, Jaffe AS, Manubolu VS, Verghese D, Hussein L, Anderson LR, Budoff MJ, Karlsberg RP. Serial changes in Troponin I in COVID-19 vaccine-associated myocarditis. Cardiology Research. 2022; 13 (4):250-4
Daniels LB, Mills NL, Mueller C, Giannitsis E, Jaffe AS, Huber K, Mair J, Cullen L, Hammarsten O, Mockel M, Krychtiuk K, Thygesen K. Use of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide in the emergency department. European Heart Journal: Acute Cardiovascular Care. 2022; 11 (5):440-1
Kavsak PA, Lam CSP, Saenger AK, Aakre KM, Body R, Hammarsten O, Collinson P, Ordonez-Llanos J, Omland T, Jaffe AS, Apple FS. Biomarker Testing Considerations in the Evaluation and Management of Patients With Heart Failure: Perspectives From the International Federation of Clinical Chemistry and Laboratory Medicine Committee. J Card Fail. 2021 Dec; 27 (12):1456-1461 Epub 2021 July 10
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Donato LJ, Wockenfus AM, Katzman BM, Baumann NA, Jaffe AS, Karon BS. Analytical and Clinical Considerations in Implementing the Roche Elecsys Troponin T Gen 5 STAT Assay. Am J Clin Pathol. 2021 Nov 8; 156 (6):1121-1129
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Harmon DM, AbouEzzeddine OF, McKie PM, Scott CG, Saenger AK, Jaffe AS. Sex-specific cut-off values for soluble suppression of tumorigenicity 2 (ST2) biomarker increase its cardiovascular prognostic value in the community. Biomarkers. 2021 Nov; 26 (7):639-646 Epub 2021 July 29
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Revuelta-Lopez E, Barallat J, Cserkoova A, Galvez-Monton C, Jaffe AS, Januzzi JL, Bayes-Genis A. Pre-analytical considerations in biomarker research: focus on cardiovascular disease. Clin Chem Lab Med. 2021 Oct 26; 59 (11):1747-1760 Epub 2021 July 06
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Duma A, Maleczek M, Wagner C, Haslacher H, Szekeres T, Jaffe AS, Nagele P. NT-proBNP in young healthy adults undergoing non-cardiac surgery. Clin Biochem. 2021 Oct; 96:38-42 Epub 2021 July 13
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Sharain K, Vasile VC, Sandoval Y, Donato LJ, Clements CM, Newman JS, Karon BS, Jaffe AS. The Elevated High-Sensitivity Cardiac Troponin T Pilot: Diagnoses and Outcomes. Mayo Clin Proc. 2021 Sep; 96 (9):2366-2375 Epub 2021 May 13
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De Michieli L, Ola O, Knott JD, Akula A, Mehta RA, Hodge DO, Dworak M, Yang EH, Gharacholou M, Singh G, Singh R, Gulati R, Jaffe AS, Sandoval Y. High-Sensitivity Cardiac Troponin T for the Detection of Myocardial Injury and Risk Stratification in COVID-19. Clin Chem. 2021 Aug 5; 67 (8):1080-1089
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Bulluck H, Paradies V, Barbato E, Baumbach A, Botker HE, Capodanno D, De Caterina R, Cavallini C, Davidson SM, Feldman DN, Ferdinandy P, Gili S, Gyongyosi M, Kunadian V, Ooi SY, Madonna R, Marber M, Mehran R, Ndrepepa G, Perrino C, Schupke S, Silvain J, Sluijter JPG, Tarantini G, Toth GG, Van Laake LW, von Birgelen C, Zeitouni M, Jaffe AS, Thygesen K, Hausenloy DJ. Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2021 Jul 15; 42 (27):2630-2642
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Vallabhajosyula S, Desai VK, Sundaragiri PR, Cheungpasitporn W, Doshi R, Singh V, Jaffe AS, Lerman A, Barsness GW. Influence of primary payer status on non-ST-segment elevation myocardial infarction: 18-year retrospective cohort national temporal trends, management and outcomes. Ann Transl Med. 2021 Jul; 9 (13):1075
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Ola O, Akula A, De Michieli L, Dworak M, Crockford E, Lobo R, Rastas N, Knott JD, Mehta RA, Hodge DO, Grube E, Karturi S, Wohlrab S, Tak T, Cagin C, Gulati R, Jaffe AS, Sandoval Y. Clinical Impact of High-Sensitivity Cardiac Troponin T Implementation in the Community. J Am Coll Cardiol. 2021 Jun 29; 77 (25):3160-3170 Epub 2021 May 03
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Jaffe AS, Lindahl B, Giannitsis E, Mueller C, Cullen L, Hammarsten O, Mockel M, Mair J, Krychtiuk KA, Huber K, Mills NL, Thygesen K. ESC Study Group on Cardiac Biomarkers of the Association for Acute CardioVascular Care: A fond farewell at the retirement of CKMB. Eur Heart J. 2021 Jun 14; 42 (23):2260-2264
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Krychtiuk KA, Speidl WS, Giannitsis E, Gigante B, Gorog DA, Jaffe AS, Mair J, Mockel M, Mueller C, Storey RF, Vilahur G, Wojta J, Huber K, Halvorsen S, Geisler T, Morais J, Lindahl B, Thygesen K. Biomarkers of coagulation and fibrinolysis in acute myocardial infarction: a joint position paper of the Association for Acute CardioVascular Care and the European Society of Cardiology Working Group on Thrombosis. Eur Heart J Acute Cardiovasc Care. 2021 May 11; 10 (3):343-355
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Mueller C, Giannitsis E, Jaffe AS, Huber K, Mair J, Cullen L, Hammarsten O, Mills NL, Mockel M, Krychtiuk K, Thygesen K, Lindahl B, ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association. Cardiovascular biomarkers in patients with COVID-19. Eur Heart J Acute Cardiovasc Care. 2021 May 11; 10 (3):310-319
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Apple FS, Collinson PO, Kavsak PA, Body R, Ordonez-Llanos J, Saenger AK, Omland T, Hammarsten O, Jaffe AS, IFCC Committee on Clinical Applications of Cardiac Bio-Markers. Getting Cardiac Troponin Right: Appraisal of the 2020 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation by the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical Applications of Cardiac Bio-Markers. Clin Chem. 2021 Apr 29; 67 (5):730-735
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Januzzi JL Jr, Canty JM, Das S, DeFilippi CR, Gintant GA, Gutstein DE, Jaffe A, Kaushik EP, Leptak C, Mehta C, Pina I, Povsic TJ, Rambaran C, Rhyne RF, Salas M, Shi VC, Udell JA, Unger EF, Zabka TS, Seltzer JH. Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week. J Am Coll Cardiol. 2021 Apr 20; 77 (15):1922-1933
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Vojjini R, Patlolla SH, Cheungpasitporn W, Kumar A, Sundaragiri PR, Doshi RP, Jaffe AS, Barsness GW, Holmes DR, Rab ST, Vallabhajosyula S. Racial Disparities in the Utilization and Outcomes of Temporary Mechanical Circulatory Support for Acute Myocardial Infarction-Cardiogenic Shock. J Clin Med. 2021 Apr 2; 10 (7) Epub 2021 Apr 02
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De Michieli L, Babuin L, Vigolo S, Berti De Marinis G, Lunardon A, Favretto F, Lobo R, Sandoval Y, Bryant SC, Donato D, Plebani M, Vettor R, Iliceto S, Cianci V, Jaffe AS. Using high sensitivity cardiac troponin values in patients with SARS-CoV-2 infection (COVID-19): The Padova experience. Clin Biochem. 2021 Apr; 90:8-14 Epub 2021 Jan 30
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Greene DN, Wu AHB, Jaffe AS. Return-to-Play Guidelines for Athletes After COVID-19 Infection. JAMA Cardiol 2021 Apr 1; 6 (4):479
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Vasile VC, Meeusen JW, Medina Inojosa JR, Donato LJ, Scott CG, Hyun MS, Vinciguerra M, Rodeheffer RR, Lopez-Jimenez F, Jaffe AS. Ceramide Scores Predict Cardiovascular Risk in the Community. Arterioscler Thromb Vasc Biol. 2021 Apr; 41 (4):1558-1569 Epub 2021 Feb 18
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Machado MN, Rodrigues FB, Nakazone MA, Martin DF, Sabbag ATR, Grigolo IH, Silva-Junior OL, Maia LN, Jaffe AS. Prediction of Death After Noncardiac Surgery: Potential Advantage of Using High-Sensitivity Troponin T as a Continuous Variable. J Am Heart Assoc. 2021 Mar 16; 10 (6):e018008 Epub 2021 Mar 04
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Fatica EM, Meeusen JW, Vasile VC, Jaffe AS, Donato LJ. Corrigendum to "Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation" [Clin. Biochem. 86 (2020) 45-51]. Clin Biochem. 2021 Feb; 88:56-57 Epub 2021 Jan 19
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Gunsolus IL, Jaffe AS, Sexter A, Schulz K, Ler R, Lindgren B, Saenger AK, Love SA, Apple FS. Sex-specific 99th percentiles derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT assay: Comorbidities and statistical methods influence derivation of reference limits. Clin Biochem. 2017 Dec; 50 (18):1073-1077 Epub 2017 Sept 13
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Brown JC, Samaha E, Rao S, Helwani MA, Duma A, Brown F, Gage BF, Miller JP, Jaffe AS, Apple FS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesth Analg. 2017 Nov; 125 (5):1455-1462
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Beunders R, Struck J, Wu AHB, Zarbock A, Di Somma S, Mehta RL, Koyner JL, Nadim MK, Maisel AS, Murray PT, Neath SX, Jaffe A, Pickkers P. Proenkephalin (PENK) as a Novel Biomarker for Kidney Function. J Appl Lab Med. 2017 Nov 1; 2 (3):400-412
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Gerber Y, Weston SA, Enriquez-Sarano M, Jaffe AS, Manemann SM, Jiang R, Roger VL. Contemporary Risk Stratification After Myocardial Infarction in the Community: Performance of Scores and Incremental Value of Soluble Suppression of Tumorigenicity-2. J Am Heart Assoc. 2017 Oct 20; 6(10).
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Alvin MD, Jaffe AS, Ziegelstein RC, Trost JC. Eliminating Creatine Kinase-Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement. JAMA Intern Med. 2017 Oct 1; 177 (10):1508-1512
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Vallabhajosyula S, Sakhuja A, Geske JB, Kumar M, Poterucha JT, Kashyap R, Kashani K, Jaffe AS, Jentzer JC. Role of Admission Troponin-T and Serial Troponin-T Testing in Predicting Outcomes in Severe Sepsis and Septic Shock. J Am Heart Assoc. 2017 Sep 9; 6 (9) Epub 2017 Sept 09
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Sharain K, Vasile VC, Jaffe AS. Does cardiac rhythm monitoring in patients with elevated troponin levels lead to changes in management? Eur Heart J Acute Cardiovasc Care. 2017 Sep; 6 (6):545-552 Epub 2016 Jan 27
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Jenkins WS, Roger VL, Jaffe AS, Weston SA, AbouEzzeddine OF, Jiang R, Manemann SM, Enriquez-Sarano M. Prognostic Value of Soluble ST2 After Myocardial Infarction: A Community Perspective. Am J Med. 2017 Sep; 130(9):1112.e9-1112.e15. Epub 2017 Mar 23.
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Babuin L, Scarpa D, Jaffe AS. Renal Dysfunction: How to Think About That in Acute Coronary Syndromes. Curr Cardiol Rep. 2017 Aug 24; 19 (10):91
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Vasile VC, Jaffe AS. High-Sensitivity Cardiac Troponin for the Diagnosis of Patients with Acute Coronary Syndromes. Curr Cardiol Rep. 2017 Aug 24; 19 (10):92
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Cullen L, Greenslade JH, Hawkins T, Hammett C, O'Kane S, Ryan K, Parker K, Schluter J, Dalton E, Brown AF, Than M, Peacock WF, Jaffe A, O'Rourke PK, Parsonage WA. Improved Assessment of Chest pain Trial (IMPACT): assessing patients with possible acute coronary syndromes. Med J Aust. 2017 Aug 4; 207 (5):195-200
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Bagai A, Alexander KP, Berger JS, Senior R, Sajeev C, Pracon R, Mavromatis K, Lopez-Sendon JL, Gosselin G, Diaz A, Perna G, Drozdz J, Humen D, Petrauskiene B, Cheema AN, Phaneuf D, Banerjee S, Miller TD, Kedev S, Schuchlenz H, Stone GW, Goodman SG, Mahaffey KW, Jaffe AS, Rosenberg YD, Bangalore S, Newby LK, Maron DJ, Hochman JS, Chaitman BR. Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis. Am Heart J. 2017 Aug; 190:135-139 Epub 2017 June 16
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Whelton SP, Meeusen JW, Donato LJ, Jaffe AS, Saenger A, Sokoll LJ, Blumenthal RS, Jones SR, Martin SS. Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg/dL compared with a novel low-density lipoprotein estimation method. J Clin Lipidol. 2017 Jul - Aug; 11 (4):1065-1072 Epub 2017 June 01
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Mair J, Lindahl B, Giannitsis E, Huber K, Thygesen K, Plebani M, Mockel M, Muller C, Jaffe AS, Biomarker Study Group of the European Society of Cardiology Acute Cardiovascular Care Association. Will sacubitril-valsartan diminish the clinical utility of B-type natriuretic peptide testing in acute cardiac care? Eur Heart J Acute Cardiovasc Care. 2017 Jun; 6 (4):321-328 Epub 2016 Jan 12
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Meeusen JW, Donato LJ, Jaffe AS. Lipid Biomarkers for Risk Assessment in Acute Coronary Syndromes. Curr Cardiol Rep. 2017 Jun; 19 (6):48
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Pickering JW, Than MP, Cullen L, Aldous S, Ter Avest E, Body R, Carlton EW, Collinson P, Dupuy AM, Ekelund U, Eggers KM, Florkowski CM, Freund Y, George P, Goodacre S, Greenslade JH, Jaffe AS, Lord SJ, Mokhtari A, Mueller C, Munro A, Mustapha S, Parsonage W, Peacock WF, Pemberton C, Richards AM, Sanchis J, Staub LP, Troughton R, Twerenbold R, Wildi K, Young J. Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis. Ann Intern Med. 2017 May 16; 166 (10):715-724 Epub 2017 Apr 18
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Jaffe AS, Januzzi JL Jr. Using Biomarkers to Guide Heart Failure Therapy. Clin Chem. 2017 May; 63 (5):954-957 Epub 2017 Mar 09
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Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Faruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, Schunemann HJ, Cortes OL, Coriat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH, Writing Committee for the VISION Study Investigators. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA. 2017 Apr 25; 317 (16):1642-1651
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Mueller C, Giannitsis E, Mockel M, Huber K, Mair J, Plebani M, Thygesen K, Jaffe AS, Lindahl B, Biomarker Study Group of the ESC Acute Cardiovascular Care Association. Rapid rule out of acute myocardial infarction: novel biomarker-based strategies. Eur Heart J Acute Cardiovasc Care. 2017 Apr; 6 (3):218-222 Epub 2016 July 01
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Mockel M, Giannitsis E, Mueller C, Huber K, Jaffe AS, Mair J, Plebani M, Thygesen K, Lindahl B, Biomarker Study Group of the European Society of Cardiology Acute Cardiovascular Care Association. Editor's Choice-Rule-in of acute myocardial infarction: Focus on troponin. Eur Heart J Acute Cardiovasc Care 2017 Apr; 6 (3):212-217 Epub 2016 June 02
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Donato LJ, Meeusen JW, Jenkins SM, Hartman SJ, Saenger AK, Baumann NA, Block DR, Jaffe AS. Biological variability of lipoprotein-associated phospholipase A2 activity in healthy individuals. Clin Biochem. 2017 Apr; 50 (6):347-349 Epub 2016 Nov 25
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Meijers WC, van der Velde AR, Muller Kobold AC, Dijck-Brouwer J, Wu AH, Jaffe A, de Boer RA. Variability of biomarkers in patients with chronic heart failure and healthy controls. Eur J Heart Fail. 2017 Mar; 19 (3):357-365 Epub 2016 Oct 21
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Beri N, Marston NA, Daniels LB, Nowak RM, Schreiber D, Mueller C, Jaffe A, Diercks DB, Wettersten N, DeFilippi C, Peacock WF, Limkakeng AT, Anand I, McCord J, Hollander JE, Wu AHB, Apple FS, Nagurney JT, Berardi C, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. Necessity of hospitalization and stress testing in low risk chest pain patients. Am J Emerg Med. 2017 Feb; 35: (2)274-280.
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Giannitsis E, Mair J, Christersson C, Siegbahn A, Huber K, Jaffe AS, Peacock WF, Plebani M, Thygesen K, Mockel M, Mueller C, Lindahl B, Biomarker Study Group of the European Society of Cardiology (ESC) Acute Cardiovascular Care Association (ACCA). How to use D-dimer in acute cardiovascular care. Eur Heart J Acute Cardiovasc Care. 2017 Feb; 6 (1):69-80 Epub 2016 Sept 22
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Kopec M, Duma A, Helwani MA, Brown J, Brown F, Gage BF, Gibson DW, Miller JP, Novak E, Jaffe AS, Apple FS, Scott MG, Nagele P. Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP. Anesth Analg. 2017 Feb; 124 (2):398-405
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Apple FS, Jaffe AS, Sharkey S, Kavsak P, Kontos MC, Saenger AK, Smith S. Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury. Clin Chem. 2017 Jan; 63 (1):37-44 Epub 2016 Oct 06
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Apple FS, Sandoval Y, Jaffe AS, Ordonez-Llanos J, IFCC Task Force on Clinical Applications of Cardiac Bio-Markers. Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care. Clin Chem. 2017 Jan; 63 (1):73-81 Epub 2016 Oct 10
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Vasile VC, Jaffe AS. Natriuretic Peptides and Analytical Barriers. Clin Chem. 2017 Jan; 63 (1):50-58 Epub 2016 Oct 10
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Saenger AK, Rodriguez-Fraga O, Ler R, Ordonez-Llanos J, Jaffe AS, Goetze JP, Apple FS. Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides. Clin Chem. 2017 Jan; 63 (1):351-358 Epub 2016 Nov 15
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Lupi A, Schaffer A, Rognoni A, Cavallino C, Bongo AS, Cortese B, Jaffe AS, Angiolillo DJ, Porto I. Intracoronary Bivalirudin Bolus in ST-Elevation Myocardial Infarction Patients Treated with Primary Angioplasty: Theoretical Bases, Clinical Experience, and Future Applications. Am J Cardiovasc Drugs. 2016 Dec; 16: (6)391-397.
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Jentzer JC, Clements CM, Wright RS, White RD, Jaffe AS. Improving Survival From Cardiac Arrest: A Review of Contemporary Practice and Challenges. Ann Emerg Med. 2016 Dec; 68 (6):678-689 Epub 2016 June 16
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Mach L, Konecny T, Helanova K, Jaffe AS, Sorenson EJ, Somers VK, Reeder GS. Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis. Acta Neurol Belg. 2016 Dec; 116: (4)557-564.
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Crea F, Jaffe AS, Collinson PO, Hamm CW, Lindahl B, Mills NL, Thygesen K, Mueller C, Patrono C, Roffi M, 2015 ESC NSTE-ACS Guidelines Task Force. Should the 1h algorithm for rule in and rule out of acute myocardial infarction be used universally? Eur Heart J. 2016 Nov 21; 37 (44):3316-3323
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Jaffe AS, Collinson PO, Hamm CW, Lindahl B, Mills NL, Thygesen K. Sometimes earlier may not be better European Heart Journal. 2016 Nov 21; 37: (44)3316-8.
AbouEzzeddine OF, McKie PM, Scott CG, Rodeheffer RJ, Chen HH, Michael Felker G, Jaffe AS, Burnett JC, Redfield MM. Biomarker-based risk prediction in the community. Eur J Heart Fail. 2016 Nov; 18 (11):1342-1350
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Clavel MA, Tribouilloy C, Vanoverschelde JL, Pizarro R, Suri RM, Szymanski C, Lazam S, Oberti P, Michelena HI, Jaffe A, Enriquez-Sarano M. Association of B-Type Natriuretic Peptide With Survival in Patients With Degenerative Mitral Regurgitation. J Am Coll Cardiol. 2016 Sep 20; 68 (12):1297-307
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Lupi A, Rognoni A, Cavallino C, Secco GG, Reale D, Cossa G, Rosso R, Bongo AS, Cortese B, Angiolillo DJ, Jaffe AS, Porto I. Intracoronary vs intravenous bivalirudin bolus in ST-elevation myocardial infarction patients treated with primary angioplasty. Eur Heart J Acute Cardiovasc Care. 2016 Sep; 5: (5)487-96.
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Bayes-Genis A, Lupon J, Jaffe AS. Can Natriuretic Peptides be Used to Guide Therapy? EJIFCC. 2016 Aug; 27 (3):208-16 Epub 2016 Aug 01
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Korley FK, Jaffe AS. High Sensitivity Cardiac Troponin Assays - How to Implement them Successfully. EJIFCC. 2016 Aug; 27 (3):217-23 Epub 2016 Aug 01
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Meeusen JW, Donato LJ, Jaffe AS. Should apolipoprotein B replace LDL cholesterol as therapeutic targets are lowered? Curr Opin Lipidol. 2016 Aug; 27 (4):359-66
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Than MP, Pickering JW, Aldous SJ, Cullen L, Frampton CM, Peacock WF, Jaffe AS, Goodacre SW, Richards AM, Ardagh MW, Deely JM, Florkowski CM, George P, Hamilton GJ, Jardine DL, Troughton RW, van Wyk P, Young JM, Bannister L, Lord SJ. Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice. Ann Emerg Med. 2016 Jul; 68 (1):93-102.e1
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AbouEzzeddine OF, French B, Mirzoyev SA, Jaffe AS, Levy WC, Fang JC, Sweitzer NK, Cappola TP, Redfield MM. From statistical significance to clinical relevance: A simple algorithm to integrate brain natriuretic peptide and the Seattle Heart Failure Model for risk stratification in heart failure. J Heart Lung Transplant. 2016 Jun; 35 (6):714-21 Epub 2016 Jan 15
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Moyer AM, Saenger AK, Willrich M, Donato LJ, Baumann NA, Block DR, Botz CM, Khan MA, Jaffe AS, Hanson CA, Karon BS. Implementation of Clinical Decision Support Rules to Reduce Repeat Measurement of Serum Ionized Calcium, Serum Magnesium, and N-Terminal Pro-B-Type Natriuretic Peptide in Intensive Care Unit Inpatients. Clin Chem. 2016 Jun; 62 (6):824-30 Epub 2016 Mar 28
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Miller WL, Saenger AK, Grill DE, Slusser JP, Bayes-Genis A, Jaffe AS. Prognostic Value of Serial Measurements of Soluble Suppression of Tumorigenicity 2 and Galectin-3 in Ambulatory Patients With Chronic Heart Failure. J Card Fail. 2016 Apr; 22 (4):249-55 Epub 2015 Aug 14
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Lupi A, Rognoni A, Lazzero M, Rolla R, Pergolini P, Bellomo G, Rossi L, Sante Bongo A, Jaffe AS. Below normal pre-procedural cardiac troponin I levels are associated with an adverse prognosis after percutaneous coronary interventions. EuroIntervention. 2016 Mar 20; 11: (12)1380-8.
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Miller WL, Jaffe AS. Biomarkers in heart failure: the importance of inconvenient details. ESC Heart Fail. 2016 Mar; 3 (1):3-10 Epub 2015 Nov 25
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Higgins JV, Watson RE Jr, Jaffe AS, Dalzell C, Acker N, Felmlee JP, Asirvatham SJ, Cha YM, Friedman PA, Kapa S. Cardiac troponin t in patients with cardiac implantable electronic devices undergoing magnetic resonance imaging Journal Of Interventional Cardiac Electrophysiology. 2016 Jan; 45: (1)91-7.
Donato LJ, Meeusen JW, Callanan H, Saenger AK, Jaffe AS. Advantages of the lipoprotein-associated phospholipase A2 activity assay. Clin Biochem. 2016 Jan; 49: (1-2)172-5.
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Marston NA, Shah KS, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Daniels LB, Hollander JE, Apple F, Nagurney J, Schreiber D, deFilippi C, Diercks D, Limkakeng A, Anand IS, Wu AH, Jaffe AS, Peacock WF, Maisel AS. Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial. Emerg Med J. 2016 Jan; 33: (1)23-9.
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Ricci F, Di Scala R, Massacesi C, Di Nicola M, Cremonese G, De Pace D, Rossi S, Griffo I, Cataldo I, Martinotti S, Rotondo D, Jaffe AS, Zimarino M, De Caterina R. Ultra-Sensitive Copeptin and Cardiac Troponin in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndromes--The COPACS Study. Am J Med. 2016 Jan; 129: (1)105-14.
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Meeusen JW, Johnson JN, Gray A, Wendt P, Jefferies JL, Jaffe AS, Donato LJ, Saenger AK. Soluble ST2 and galectin-3 in pediatric patients without heart failure. Clin Biochem. 2015 Dec; 48 (18):1337-40 Epub 2015 Aug 12
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Newman DB, Siontis KC, Chandrasekaran K, Jaffe AS, Kashiwagi DT. Intervention to reduce inappropriate ionized calcium ordering practices: a quality-improvement project. Perm J. 2015 Winter; 19 (1):49-51
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Hickson LJ, Rule AD, Butler KR Jr, Schwartz GL, Jaffe AS, Bartley AC, Mosley TH Jr, Turner ST. Troponin T as a Predictor of End-Stage Renal Disease and All-Cause Death in African Americans and Whites From Hypertensive Families. Mayo Clin Proc. 2015 Nov; 90 (11):1482-91 Epub 2015 Oct 19
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Jaffe AS, Sara JD. MY APPROACH to cardiac troponin elevations in patients with renal disease. Trends Cardiovasc Med. 2015 Oct; 25: (7)655-6.
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Meeusen JW, Snozek CL, Baumann NA, Jaffe AS, Saenger AK. Reliability of Calculated Low-Density Lipoprotein Cholesterol. Am J Cardiol. 2015 Aug 15; 116(4):538-40. Epub 2015 May 21.
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Korley FK, George RT, Jaffe AS, Rothman RE, Sokoll LJ, Fernandez C, Falk H, Post WS, Saheed MO, Gerstenblith G, Berkowitz SA, Hill PM. Low high-sensitivity troponin I and zero coronary artery calcium score identifies coronary CT angiography candidates in whom further testing could be avoided. Acad Radiol. 2015 Aug; 22 (8):1060-7 Epub 2015 June 03
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Landesberg G, Levin PD, Gilon D, Goodman S, Georgieva M, Weissman C, Jaffe AS, Sprung CL, Barak V. Myocardial Dysfunction in Severe Sepsis and Septic Shock: No Correlation With Inflammatory Cytokines in Real-life Clinical Setting. Chest. 2015 Jul; 148: (1)93-102.
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Body R, Burrows G, Carley S, Cullen L, Than M, Jaffe AS, Lewis PS. High-sensitivity cardiac troponin t concentrations below the limit of detection to exclude acute myocardial infarction: a prospective evaluation. Clin Chem. 2015 Jul; 61 (7):983-9 Epub 2015 May 15
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Aw TC, van Wijk XM, Wu AH, Jaffe AS. Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clin Chim Acta. 2015 Jun 15; 446:6-8.
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Dispenzieri A, Gertz MA, Saenger A, Kumar SK, Lacy MQ, Buadi FK, Dingli D, Leung N, Zeldenrust S, Hayman SR, Kapoor P, Grogan M, Hwa L, Russell SJ, Go RS, Rajkumar SV, Kyle RA, Jaffe A. Soluble suppression of tumorigenicity 2 (sST2), but not galactin-3, adds to prognostication in patients with systemic AL amyloidosis independent of NT-proBNP and troponin T. Am J Hematol. 2015 Jun; 90: (6)524-8.
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Mahmoud KD, Hillege HL, Jaffe AS, Lennon RJ, Holmes DR Jr. Biochemical Validation of Patient-Reported Symptom Onset Time in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2015 May; 8 (6):778-787
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Manemann SM, Gerber Y, Chamberlain AM, Dunlay SM, Bell MR, Jaffe AS, Weston SA, Killian JM, Kors J, Roger VL. Acute coronary syndromes in the community. Mayo Clin Proc. 2015 May; 90 (5):597-605 Epub 2015 Mar 18
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Shah AS, McAllister DA, Mills R, Lee KK, Churchhouse AM, Fleming KM, Layden E, Anand A, Fersia O, Joshi NV, Walker S, Jaffe AS, Fox KA, Newby DE, Mills NL. Sensitive troponin assay and the classification of myocardial infarction. Am J Med. 2015 May; 128 (5):493-501.e3 Epub 2014 Nov 28
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Shah KS, Marston NA, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney J, Schreiber D, deFilippi C, Hogan CJ, Diercks DB, Limkakeng A, Anand IS, Wu AH, Clopton P, Jaffe AS, Peacock WF, Maisel AS. Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial. Acad Emerg Med. 2015 May; 22 (5):554-63 Epub 2015 Apr 23
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Mueller T, Jaffe AS. Soluble ST2--analytical considerations. Am J Cardiol. 2015 Apr 02; 115: (7 Suppl)8B-21B.
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Apple FS, Jaffe AS, Collinson P, Mockel M, Ordonez-Llanos J, Lindahl B, Hollander J, Plebani M, Than M, Chan MH, International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Bio-Markers. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem. 2015 Mar; 48 (4-5):201-3 Epub 2014 Sept 07
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Sara JD, Holmes DR Jr, Jaffe AS. Fundamental concepts of effective troponin use: important principles for internists. Am J Med. 2015 Feb; 128 (2):111-9 Epub 2014 Sept 16
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Aradi D, Collet JP, Mair J, Plebani M, Merkely B, Jaffe AS, Mockel M, Giannitsis E, Thygesen K, ten Berg JM, Mueller C, Storey RF, Lindah B, Huber K. Platelet function testing in acute cardiac care - is there a role for prediction or prevention of stent thrombosis and bleeding? Thromb Haemost. 2015 Feb; 113(2):221-30.
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Dallmeier D, Denkinger M, Peter R, Rapp K, Jaffe AS, Koenig W, Rothenbacher D, ActiFE Study Group. Sex-specific associations of established and emerging cardiac biomarkers with all-cause mortality in older adults: the ActiFE study. Clin Chem. 2015 Feb; 61 (2):389-99 Epub 2014 Dec 10
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Engler RJ, Nelson MR, Collins LC Jr, Spooner C, Hemann BA, Gibbs BT, Atwood JE, Howard RS, Chang AS, Cruser DL, Gates DG, Vernalis MN, Lengkeek MS, McClenathan BM, Jaffe AS, Cooper LT, Black S, Carlson C, Wilson C, Davis RL. A prospective study of the incidence of myocarditis/pericarditis and new onset cardiac symptoms following smallpox and influenza vaccination. PLoS One. 2015; 10 (3):e0118283 Epub 2015 Mar 20
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Lipinski MJ, Baker NC, Escarcega RO, Torguson R, Chen F, Aldous SJ, Christ M, Collinson PO, Goodacre SW, Mair J, Inoue K, Lotze U, Sebbane M, Cristol JP, Freund Y, Chenevier-Gobeaux C, Meune C, Eggers KM, Pracon R, Schreiber DH, Wu AH, Ordonez-Llanos J, Jaffe AS, Twerenbold R, Mueller C, Waksman R. Comparison of conventional and high-sensitivity troponin in patients with chest pain: a collaborative meta-analysis. Am Heart J. 2015 Jan; 169 (1):6-16.e6 Epub 2014 Oct 22
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Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 ANA-ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines JACC. 2014; 64(24):e139-e228. Epub 2014 Sep 18.
Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr., Ganiats TG, Holmes DR Jr., Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC Guidelihe for the management of patients with non-ST0elevation acute coronary syndromes: Executive Summary: A report of the American College of Cardioldogy/American Heart Association Task Force on Practice Guidelines JACC. 2014; 64(24):2645-2687. Epub 2014 Sep 18.
Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: Executive Summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice guidelines. Circ. 2014 Dec 2; 130(23):2071-2104. Epub 2014 Sep 23
Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr., Ganiats TG, Holmes DR Jr., Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Circulation. 2014; 130(23):e199 - e267. Epub 2014 Sep 23.
Karon BS, Tolan NV, Koch CD, Wockenfus AM, Miller RS, Lingineni RK, Pruthi RK, Chen D, Jaffe AS. Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy. Clin Chem. 2014 Dec; 60 (12):1524-31 Epub 2014 Oct 03
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Meeusen JW, Lueke AJ, Jaffe AS, Saenger AK. Validation of a proposed novel equation for estimating LDL cholesterol. Clin Chem. 2014 Dec; 60 (12):1519-23 Epub 2014 Oct 21
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Jaffe AS, Moeckel M, Giannitsis E, Huber K, Mair J, Mueller C, Plebani M, Thygesen K, Lindahl B. In search for the Holy Grail: suggestions for studies to define delta changes to diagnose or exclude acute myocardial infarction: a position paper from the study group on biomarkers of the Acute Cardiovascular Care Association. Eur Heart J Acute Cardiovasc Care. 2014 Dec; 3(4):313-6. Epub 2014 Jul 09.
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Kavsak PA, Jaffe AS, Hickman PE, Mills NL, Humphries KH, McRae A, Devereaux PJ, Lamy A, Whitlock R, Dhesy-Thind SK, Potter JM, Worster A. Canadian Institutes of Health Research dissemination grant on high-sensitivity cardiac troponin. Clin Biochem. 2014 Nov; 47 (16-17):155-7 Epub 2014 Oct 07
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Hasin T, Kushwaha SS, Lesnick TG, Kremers W, Boilson BA, Schirger JA, Clavell AL, Rodeheffer RJ, Frantz RP, Edwards BS, Pereira NL, Stulak JM, Joyce L, Daly R, Park SJ, Jaffe AS. Early trends in N-terminal pro-brain natriuretic peptide values after left ventricular assist device implantation for chronic heart failure. Am J Cardiol. 2014 Oct 15; 114 (8):1257-63 Epub 2014 Aug 01
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Apple FS, Hollander J, Wu AH, Jaffe AS. Improving the 510(k) FDA process for cardiac troponin assays: in search of common ground. Clin Chem. 2014 Oct; 60 (10):1273-5 Epub 2014 Aug 11
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Sara JDS, Jaffe AS. What will change with highly sensitive troponin assays: In search of common ground. MGM Journal of Med Sci. 2014 Oct-Dec; 1(4):174-186.
White HD, Thygesen K, Alpert JS, Jaffe AS. Republished: clinical implications of the third universal definition of myocardial infarction. Postgrad Med J. 2014 Sep; 90: (1067)502-10.
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Jaffe A. Troponin - serial measurements. European Heart Journal Acute Cardiovascular Care. Sept 2014; 51(3):2.
McKie PM, AbouEzzeddine OF, Scott CG, Mehta R, Rodeheffer RJ, Redfield MM, Burnett JC Jr, Jaffe AS. High-sensitivity troponin I and amino-terminal pro--B-type natriuretic peptide predict heart failure and mortality in the general population. Clin Chem. 2014 Sep; 60 (9):1225-33 Epub 2014 July 01
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Thygesen K, Jaffe AS, Apple F, Mockel M, Venge P, Plebani M, deFillipi C, Frye B, Wallseth A, Lindenau SV. Excellence in acute cardiac care: an overview of the seminar proceedings EHJ Acute Cardio Care. 2014; 3(Sup 1):1 - 16.
Biener M, Mueller M, Vafaie M, Jaffe AS, Katus HA, Giannitsis E. Prognostic performance of high-sensitivity cardiac troponin T kinetic changes adjusted for elevated admission values and the GRACE score in an unselected emergency department population. Clin Chim Acta. 2014 Aug 5; 435:29-35. Epub 2014 Apr 26.
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Lin DC, Diamandis EP, Januzzi JL Jr, Maisel A, Jaffe AS, Clerico A. Natriuretic peptides in heart failure. Clin Chem. 2014 Aug; 60 (8):1040-6 Epub 2014 Apr 03
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Herrmann J, Lennon RJ, Jaffe AS, Holmes DR Jr, Rihal CS, Prasad A. Defining the optimal cardiac troponin T threshold for predicting death caused by periprocedural myocardial infarction after percutaneous coronary intervention. Circ Cardiovasc Interv. 2014 Aug; 7(4):533-42. Epub 2014 Jul 22.
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Apple FS, Jaffe AS. Men are different than women: it's true for cardiac troponin too. Clin Biochem. 2014 Jul; 47 (10-11):867-8 Epub 2014 June 11
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Vasile VC, Jaffe AS. Emerging biomarkers for acute heart conditions. Curr Opin Cardiol. 2014 Jul; 29 (4):312-8
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Carney RM, Steinmeyer B, Freedland KE, Stein PK, Hayano J, Blumenthal JA, Jaffe AS. Nocturnal patterns of heart rate and the risk of mortality after acute myocardial infarction. Am Heart J. 2014 Jul; 168 (1):117-25 Epub 2014 Apr 27
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Clavel MA, Malouf J, Michelena HI, Suri RM, Jaffe AS, Mahoney DW, Enriquez-Sarano M. B-type natriuretic peptide clinical activation in aortic stenosis: impact on long-term survival. J Am Coll Cardiol. 2014 May 20; 63 (19):2016-25 Epub 2014 Mar 26
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Landesberg G, Jaffe AS, Gilon D, Levin PD, Goodman S, Abu-Baih A, Beeri R, Weissman C, Sprung CL, Landesberg A. Troponin elevation in severe sepsis and septic shock: the role of left ventricular diastolic dysfunction and right ventricular dilatation*. Crit Care Med. 2014 Apr; 42 (4):790-800
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DeFilippis AP, Rai SN, Cambon A, Miles RJ, Jaffe AS, Moser AB, Jones RO, Bolli R, Schulman SP. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity. Nutr Metab Cardiovasc Dis. 2014 Apr; 24 (4):428-33 Epub 2013 Oct 23
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Dispenzieri A, Gertz MA, Kumar SK, Lacy MQ, Kyle RA, Saenger AK, Grogan M, Zeldenrust SR, Hayman SR, Buadi F, Greipp PR, Leung N, Russell SR, Dingli D, Lust JA, Rajkumar SV, Jaffe AS. High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis. Heart. 2014 Mar; 100 (5):383-8 Epub 2014 Jan 08
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Lichtman JH, Froelicher ES, Blumenthal HA, Carney RM, Doering LV, Frasure-Smith N, Freedland KE, Jaffe AS, Leifheit-Limson EC, Sheps DS, Vaccarino V, Wulsin L. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: Systematic review and recommendations. Circ. 2014 Mar; 129(12):1350-1369.
Alpert JS, Thygesen KA, White HD, Jaffe AS. Diagnostic and therapeutic implications of type 2 myocardial infarction: review and commentary. Am J Med. 2014 Feb; 127(2):105-8. Epub 2013 Oct 16.
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Mair J, Jaffe AS. Biomarker tests for risk assessment in coronary artery disease: will they change clinical practice? Mol Diagn Ther. 2014 Feb; 18(1):5-15.
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Schulz O, Postnikov AB, Smolyanova TI, Katrukha AG, Schimke I, Jaffe AS. Clinical differences between total PAPP-A and measurements specific for the products of free PAPP-A activity in patients with stable cardiovascular disease. Clin Biochem. 2014 Feb; 47 (3):177-83 Epub 2013 Nov 05
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Korley FK, Schulman SP, Sokoll LJ, Defilippis AP, Stolbach AI, Bayram JD, Saheed MO, Omron R, Fernandez C, Lwin A, Cai SS, Post WS, Jaffe AS. Troponin elevations only detected with a high-sensitivity assay: Clinical correlations and prognostic significance. Acad Emerg Med. 2014; 21(7):728-35.
Korley FK, Jaffe AS. High-sensitivity troponin: Where are we now and where do we go from here? Biomark. Med. 2014; 8(8):1021-32.
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White H, Thygesen K, Alpert JS, Jaffe A. Universal MI definition update for cardiovascular disease. Curr Cardiol Rep. 2014; 16(6):492.
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White HD, Thygesen K, Alpert JS, Jaffe AS. Clinical implications of the Third Universal Definition of Myocardial Infarction. Heart. 2014; 100(5):424-32.
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Vasile VC, Chai HS, Abdeldayem D, Afessa B, Jaffe AS. Elevated cardiac troponin T levels in critically ill patients with sepsis. Am J Med. 2013 Dec; 126 (12):1114-21 Epub 2013 Sept 28
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Biasucci LM, Koenig W, Mair J, Mueller C, Plebani M, Lindahl B, Rifai N, Venge P, Hamm C, Giannitsis E, Huber K, Galvani M, Tubaro M, Collinson P, Alpert JS, Hasin Y, Katus H, Jaffe AS, Thygesen K, the study group on biomarkers in cardiology of the acute cardiovascular care association of the European Society of Cardiology. How to use C-reactive protein in acute coronary care. EHJ. 2013 Dec; 34(48):3687-3690.
Koerbin G, Abhayaratna WP, Potter JM, Apple FS, Jaffe AS, Ravalico TH, Hickman PE. Effect of population selection on 99th percentile values for a high sensitivity cardiac troponin I and T assays. Clin Biochem. 2013 Nov; 46(16-17):1636-43. Epub 2013 Aug 24.
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Cullen L, Mueller C, Parsonage WA, Wildi K, Greenslade JH, Twerenbold R, Aldous S, Meller B, Tate JR, Reichlin T, Hammett CJ, Zellweger C, Ungerer JPJ, Rubini Gimenez M, Troughton R, Murray K, Brown AFT, Mueller M, George P, Mosimann T, Flaws DF, Reiter M, Lamanna A, Haaf P, Pemberton CJ, Richards AM, Chu K, Reid CM, Peacock WF, Jaffe AS, Florkowski C, Deely JM, Than M. Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. J Am Coll Cardiol. 2013 Oct 1; 62 (14):1242-1249 Epub 2013 Apr 10
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Schneider DJ, Avera ES, Bergmann SR, Braunwald E, Collen D, Frye R, Jaffe A, Kirk RJ, Ludbrook PA, Roberts R, Spector P, Vlasuk GP, Willerson JT. In memoriam: Burton E. Sobel a tribute from family, friends and colleagues October 21, 1937 - May 3, 2013. Exp Biol Med (Maywood). 2013 Oct; 238(10):1101-15.
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Hammarsten O, Jacobsson CE, Widegren M, Danylchenko T, Jaffe AS. Long-time quality assessment of the Elecsys Troponin T hs assay. Clin Biochem. 2013 Aug; 46 (12):1055-1057 Epub 2013 Apr 09
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Santalo M, Martin A, Velilla J, Povar J, Temboury F, Balaguer J, Munoz M, Calmarza P, Ortiz C, Carratala A, Gich I, Merce J, Jaffe AS, Ordonez-Llanos J. Using high-sensitivity troponin T: the importance of the proper gold standard. Am J Med. 2013 Aug; 126(8):709-17. Epub 2013 Jun 10.
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Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J. 2013 Aug; 166(2):325-332.e1. Epub 2013 Jun 24.
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Maisel A, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke G, Daniels LB, Hollander JE, Apple FS, Cannon C, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Stein JC, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Papassotiriou J, Hartmann O, Ebmeyer S, Clopton P, Jaffe AS, Peacock WF. Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol. 2013 Jul 9; 62 (2):150-160 Epub 2013 Apr 30
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McKie PM, Heublein DM, Scott CG, Gantzer ML, Mehta RA, Rodeheffer RJ, Redfield MM, Burnett JC Jr, Jaffe AS. Defining high-sensitivity cardiac troponin concentrations in the community. Clin Chem. 2013 Jul; 59 (7):1099-107 Epub 2013 Apr 16
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Davidson KW, Bigger JT, Burg MM, Carney RM, Chaplin WF, Czajkowski S, Dornelas E, Duer-Hefele J, Frasure-Smith N, Freedland KE, Haas DC, Jaffe AS, Ladapo JA, Lesperance F, Medina V, Newman JD, Osorio GA, Parsons F, Schwartz JE, Shaffer JA, Shapiro PA, Sheps DS, Vaccarino V, Whang W, Ye S. Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial. JAMA Intern Med. 2013 Jun 10; 173(11):997-1004.
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Wu AH, Wians F, Jaffe A. Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test results. Am Heart J. 2013 Jun; 165(6):995-9. Epub 2013 Apr 06.
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Dunlay SM, Jaffe AS. Are biomarkers the answer to the heart failure readmissions problem? Clin Chem. 2013 May; 59 (5):737-9 Epub 2013 Mar 07
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Liang JJ, Killu AM, Osborn MJ, Jaffe AS. Pacemaker lead perforation causing hemopericardium eight years after implantation. Indian Heart J. 2013 May-Jun; 65 (3):331-3 Epub 2013 Apr 09
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Korley FK, Jaffe AS. Preparing the United States for high-sensitivity cardiac troponin assays. J Am Coll Cardiol. 2013 Apr 30; 61(17):1753-8. Epub 2013 Feb 06.
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Miller WL, Grill DE, Struck J, Jaffe AS. Association of hyponatremia and elevated copeptin with death and need for transplantation in ambulatory patients with chronic heart failure. Am J Cardiol. 2013 Mar 15; 111(6):880-5. Epub 2012 Dec 28.
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Nordenskjold AM, Ahlstrom H, Eggers KM, Frobert O, Jaffe AS, Venge P, Lindahl B. Short- and long-term individual variation in cardiac troponin in patients with stable coronary artery disease. Clin Chem. 2013 Feb; 59(2):401-9. Epub 2012 Nov 09.
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Keddis MT, El-Zoghby ZM, El Ters M, Rodrigo E, Pellikka PA, Jaffe AS, Cosio FG. Cardiac troponin T before and after kidney transplantation: determinants and implications for posttransplant survival. Am J Transplant. 2013 Feb; 13 (2):406-14 Epub 2012 Nov 08
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Biener M, Mueller M, Vafaie M, Jaffe AS, Widera C, Katus HA, Giannitsis E. Diagnostic performance of rising, falling, or rising and falling kinetic changes of high-sensitivity cardiac troponin T in an unselected emergency department population. European Heart Journal: Acute Cardiovascular Care. 2013; 2(4):314-22.
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Jaffe AS. Third universal definition of myocardial infarction. Clin Biochem. 2013 Jan; 46(1-2):1-4. Epub 2012 Nov 02.
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DeFilippis AP, Oloyede OS, Andrikopoulou E, Saenger AK, Palachuvattil JM, Fasoro YA, Guallar E, Blumenthal RS, Kickler TS, Jaffe AS, Gerstenblith G, Schulman SP, Rade JJ. Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction. Circ J. 2013; 77(11):2786-92. Epub 2013 Aug 27.
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Olaf S, Debora B, Ricarda B, Gunnar B, Jochen K, Schimke I, Halle M, Jaffe A. Exercise tolerance in asymptomatic patients with moderate-severe valvular heart disease and preserved ejection fraction. Arch Med Sci. 2012 Dec 20; 8(6):1018-26. Epub 2012 Dec 19.
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Sheldon SH, Crandall MA, Jaffe AS. Myocarditis with ST elevation and elevated cardiac enzymes misdiagnosed as an ST-elevation myocardial infarction. J Emerg Med. 2012 Dec; 43(6):996-9. Epub 2010 Dec 16.
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Kaleta EJ, Jaffe AS, Baumann NA, Block DR. A case of floating gel. Clin Chem. 2012 Nov; 58 (11):1604-5
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Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. Nat Rev Cardiol. 2012 Nov; 9(11):620-33. Epub 2012 Aug 25
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Sheldon SH, Saenger AK, Jaffe AS. Incidence and significance of elevated lactate in the identification of critically ill patients. Clin Chem Lab Med. 2012 Oct 1; 50: (10)1819-23.
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Thygesen K Alpert JS Jaffe AS Simoons ML Chaitman BR White HD, the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. Third Universal Definition of Myocardial Infarction. Circulation. 2012 Oct; 126(16):2020-2035.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Thygesen K, Alpert JS, White HD, Jaffe AS, Katus HA, Apple FS, Jaffe AS, Lindahl B, Morrow DA, Chaitman BA, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow RO, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S, Writing Group on the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction//ESC Committee for Practice Guidelines (CPG). Third universal definition of myocardial infarction. Eur Heart J 2012 Oct; 33 (20):2551-67 Epub 2012 Aug 24
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Whang W, Burg MM, Carney RM, Freedland KE, Bigger JT, Catellier D, Czajkowski S, Frasure-Smith N, Haas DC, Jaffe AS, Lesperance F, Medina V, Duer-Hefele J, Osorio GA, Parsons F, Shapiro PA, Sheps DS, Vaccarino V, Davidson KW. Design and baseline data from the vanguard of the Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS) randomized controlled trial. Contemp Clin Trials. 2012 Sep; 33(5):1003-10. Epub 2012 May 25.
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Thygesen K, Mair J, Giannitsis E, Mueller C, Lindahl B, Blankenberg S, Huber K, Plebani M, Biasucci LM, Tubaro M, Collinson P, Venge P, Hasin Y, Galvani M, Koenig W, Hamm C, Alpert JS, Katus H, Jaffe AS, The Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. How to use high-sensitivity cardiac troponins in acute cardiac care. EHJ. 2012 Sept; 33(18):2252-2257. Epub 2012 Jun 21
Thygesen K Alpert JS Jaffe AS Simoons ML Chaitman R White HD, Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task FOrce for the universal definition of mocardial infarction. Third universal definition of myocardial infarction. JACC. 2012 Aug 29; 60(16):1581-1598.
Thygesen K, Mair J, Mueller C, Huber K, Weber M, Plebani M, Hasin Y, Biasucci LM, Giannitsis E, Lindahl B, Koenig W, Tubaro M, Collinson P, Katus H, Galvani M, Venge P, Alpert JS, Hamm C, Jaffe AS, Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Recommendations for the use of natriuretic peptides in acute cardiac care: a position statement from the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Eur Heart J. 2012 Aug; 33(16):2001-6. Epub 2011 Feb 2
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Dunlay SM, Weston SA, Killian JM, Bell MR, Jaffe AS, Roger VL. Thirty-day rehospitalizations after acute myocardial infarction: a cohort study. Ann Intern Med. 2012 Jul 3; 157 (1):11-8
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Ayub B, Martinez MW, Jaffe AS, Couri DM. Giant saphenous vein graft pseudoaneurysm: treatment with a vascular occlusion device. Interact Cardiovasc Thorac Surg. 2012 Jul; 15(1):164-5. Epub 2012 Mar 28.
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Koch CD, Wockenfus AM, Saenger AK, Jaffe AS, Karon BS. BD rapid serum tubes reduce false positive plasma troponin T results on the Roche Cobas e411 analyzer. Clin Biochem. 2012 Jul; 45(10-11):842-4. Epub 2012 Apr 26.
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Jaffe AS. Troponin--past, present, and future. Curr Probl Cardiol. 2012 Jun; 37(6):209-28.
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Deo S, Greason KL, Gulati R, Jaffe AS, Holmes DR. Balloon aortic valvuloplasty under temporary mechanical circulatory support as a bridge to aortic valve replacement in a patient with hemodynamic failure secondary to critical aortic valve stenosis. Heart Surg Forum. 2012 Jun; 15(3):E177-9.
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Miller WL, Grill DE, Jaffe AS. Comparison of novel pro-BNP(1-108) and standard BNP assays in heart failure patients. Clin Chim Acta. 2012 May 18; 413(9-10):920-6. Epub 2012 Feb 16.
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Jaffe AS, Apple FS, Lindahl B, Mueller C, Katus HA. Why all the struggle about CK-MB and PCI? Eur Heart J. 2012 May; 33(9):1046-8. Epub 2012 Jan 11.
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Landesberg G, Gilon D, Meroz Y, Georgieva M, Levin PD, Goodman S, Avidan A, Beeri R, Weissman C, Jaffe AS, Sprung CL. Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J. 2012 Apr; 33(7):895-903. Epub 2011 Sep 11
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Twerenbold R, Jaffe A, Reichlin T, Reiter M, Mueller C. High-sensitive troponin T measurements: what do we gain and what are the challenges? Eur Heart J. 2012 Mar; 33(5):579-86. Epub 2012 Jan 19.
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Gerber Y, Jaffe AS, Weston SA, Jiang R, Roger VL. Prognostic value of cardiac troponin T after myocardial infarction: a contemporary community experience. Mayo Clin Proc. 2012 Mar; 87 (3):247-54
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Miller WL, Hartman KA, Grill DE, Struck J, Bergmann A, Jaffe AS. Serial measurements of midregion proANP and copeptin in ambulatory patients with heart failure: incremental prognostic value of novel biomarkers in heart failure. Heart. 2012 Mar; 98 (5):389-94 Epub 2011 Dec 22
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Hess EP, Brison RJ, Perry JJ, Calder LA, Thiruganasambandamoorthy V, Agarwal D, Sadosty AT, Silvilotti ML, Jaffe AS, Montori VM, Wells GA, Stiell IG. Development of a clinical prediction rule for 30-day cardiac events in emergency department patients with chest pain and possible acute coronary syndrome. Ann Emerg Med. 2012 Feb; 59 (2):115-25.e1 Epub 2011 Sept 01
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Pervaiz MA, Gau G, Jaffe AS, Saenger AK, Baudhuin L, Ellison J. A Non-classical Presentation of Tangier Disease with Three ABCA1 Mutations. JIMD Rep. 2012; 4:109-11 Epub 2011 Sept 28
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Jaffe AS, Wu AH. Troponin release--reversible or irreversible injury? Should we care? Clin Chem. 2012 Jan; 58 (1):148-50 Epub 2011 Oct 28
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Eggers KM, Jaffe AS, Svennblad B, Lindahl B. A novel approach to cardiac troponins to improve the diagnostic work-up in chest pain patients. Critical Pathways in Cardiology. 2012; 11(4):199-205.
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Jaffe AS, Apple FS. The third universal definition of myocardial infarction - Moving forward. Clin Chem. 2012; 58(12):1727-8.
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Koerbin G, Potter JM, Abhayaratna WP, Telford RD, Badrick T, Apple FS, Jaffe AS, Hickman PE. Longitudinal studies of cardiac troponin I in a large cohort of healthy children. Clin Chem. 2012; 58(12):1665-72.
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Schmickl CN, Shahjehan K, Li G, Dhokarh R, Kashyap R, Janish C, Alsara A, Jaffe AS, Hubmayr RD, Gajic O. Decision support tool for early differential diagnosis of acute lung injury and cardiogenic pulmonary edema in medical critically ill patients. Chest. 2012 Jan; 141 (1):43-50 Epub 2011 Oct 26
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Katus HA, Giannitsis E, Jaffe AS. Interpreting changes in troponin--clinical judgment is essential. Clin Chem. 2012 Jan; 58(1):39-43.
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Jaffe AS, Vasile VC, Milone M, Saenger AK, Olson KN, Apple FS. Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. J Am Coll Cardiol. 2011 Oct 18; 58 (17):1819-24 Epub 2011 Sept 29
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Oliver LK, Voskoboev N, Heser D, McConnell JP, Hodel-Hanson S, Callanan H, Jaffe AS. Assessment of clinical performance without adequate analytical validation: A prescription for confusion. Clin Biochem. 2011 Oct; 44(14-15):1247-52. Epub 2011 Jul 20.
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Body R, Carley S, McDowell G, Jaffe AS, France M, Cruickshank K, Wibberley C, Nuttall M, Mackway-Jones K. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol. 2011 Sep 20; 58(13):1332-9.
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Jaffe AS. The 10 commandments of troponin, with special reference to high sensitivity assays. Heart. 2011 Jun; 97(11):940-6.
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Schulz O, Reinicke M, Kramer J, Berghofer G, Bensch R, Schimke I, Jaffe A. Pregnancy-associated plasma protein A values in patients with stable cardiovascular disease: use of a new monoclonal antibody-based assay. Clin Chim Acta. 2011 May 12; 412(11-12):880-6. Epub 2011 Jan 14.
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Miller WL, Phelps MA, Wood CM, Schellenberger U, Van Le A, Perichon R, Jaffe AS. Comparison of mass spectrometry and clinical assay measurements of circulating fragments of B-type natriuretic peptide in patients with chronic heart failure. Circ Heart Fail. 2011 May; 4(3):355-60. Epub 2011 Feb 03.
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Arruda-Olson AM, Roger VL, Jaffe AS, Hodge DO, Gibbons RJ, Miller TD. Troponin T levels and infarct size by SPECT myocardial perfusion imaging. JACC Cardiovasc Imaging. 2011 May; 4 (5):523-33
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Saenger AK, Beyrau R, Braun S, Cooray R, Dolci A, Freidank H, Giannitsis E, Gustafson S, Handy B, Katus H, Melanson SE, Panteghini M, Venge P, Zorn M, Jarolim P, Bruton D, Jarausch J, Jaffe AS. Multicenter analytical evaluation of a high-sensitivity troponin T assay. Clin Chim Acta. 2011 Apr 11; 412 (9-10):748-54 Epub 2011 Jan 08
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Martinez MW, Rasmussen KG, Mueller PS, Jaffe AS. Troponin elevations after electroconvulsive therapy: the need for caution. Am J Med. 2011 Mar; 124(3):229-34.
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Hallen J, Jensen JK, Buser P, Jaffe AS, Atar D. Relation of cardiac troponin I and microvascular obstruction following ST-elevation myocardial infarction. Acute Card Care. 2011 Mar; 13(1):48-51. Epub 2011 Jan 18.
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Eggers KM, Jaffe AS, Venge P, Lindahl B. Clinical implications of the change of cardiac troponin I levels in patients with acute chest pain - an evaluation with respect to the Universal Definition of Myocardial Infarction. Clin Chim Acta. 2011 Jan 14; 412(1-2):91-7. Epub 2010 Sep 22.
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Hallen J, Jensen JK, Fagerland MW, Jaffe AS, Atar D. Cardiac troponin I for the prediction of functional recovery and left ventricular remodelling following primary percutaneous coronary intervention for ST-elevation myocardial infarction. Heart. 2010 Dec; 96(23):1892-7.
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Vasile VC, Chai HS, Khambatta S, Afessa B, Jaffe AS. Significance of elevated cardiac troponin T levels in critically ill patients with acute respiratory disease. Am J Med. 2010 Nov; 123 (11):1049-58
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Hallen J, Johansen OE, Birkeland KI, Gullestad L, Aakhus S, Endresen K, Tjora S, Jaffe AS, Atar D. Determinants and prognostic implications of Cardiac Troponin T measured by a sensitive assay in Type 2 Diabetes Mellitus. Cardiovascular Diabetology. 2010 Sep 15; 9.
Thygesen K, Johannes M, Katus H, Plebani M, Verge P, Collinson P, Lindahl B, Giannitsis E, Hasin Y, Galvani M, Tubaro M, Alpert JS, Biasucci LM, Koenig W, Mueller CH, Huber K, Hamm C, Jaffe AS. The Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care Recommendations for the use of cardiac troponin measurement in acute cardiac care. EHJ. 2010 Sept; 31(18):2197-2204.
Baudhuin LM, Miller WL, Train L, Bryant S, Hartman KA, Phelps M, Larock M, Jaffe AS. Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure. Am J Cardiol. 2010 Aug 1; 106 (3):402-8
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Vasile VC, Saenger AK, Kroning JM, Jaffe AS. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay. Clin Chem. 2010 Jul; 56 (7):1086-90 Epub 2010 May 14
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Schulz O, Reinicke M, Berghoefer GH, Bensch R, Kraemer J, Schimke I, Jaffe AS. High-sensitive cardiac troponin I (hs-cTnI) values in patients with stable cardiovascular disease: an initial foray. Clin Chim Acta. 2010 Jun 3; 411(11-12):812-7. Epub 2010 Feb 24.
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Jaffe AS, Apple FS, Morrow DA, Lindahl B, Katus HA. Being rational about (im)precision: a statement from the Biochemistry Subcommittee of the Joint European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/World Heart Federation Task Force for the definition of myocardial infarction. Clin Chem. 2010 Jun; 56 (6):941-3 Epub 2010 Apr 01
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Apple FS, Wu A, Collinson P, Jaffe A, Morrow D. High-sensitivity cardiac troponin assays: what analytical and clinical issues need to be addressed before introduction into clinical practice? (Q&A) Clin Chem. 2010 Jun; 56(6):886-91.
Kavsak PA, Worster A, You JJ, Oremus M, Elsharif A, Hill SA, Devereaux PJ, MacRae AR, Jaffe AS. Identification of myocardial injury in the emergency setting. Clin Biochem. 2010 Apr; 43(6):539-44. Epub 2009 Dec 21.
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Arruda-Olson AM, Enriquez-Sarano M, Bursi F, Weston SA, Jaffe AS, Killian JM, Roger VL. Left ventricular function and C-reactive protein levels in acute myocardial infarction. Am J Cardiol. 2010 Apr 1; 105 (7):917-21
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Hess EP, Perry JJ, Calder LA, Thiruganasambandamoorthy V, Body R, Jaffe A, Wells GA, Stiell IG. Prospective validation of a modified thrombolysis in myocardial infarction risk score in emergency department patients with chest pain and possible acute coronary syndrome. Acad Emerg Med. 2010 Apr; 17 (4):368-75
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Jaffe AS, Apple FS. High-sensitivity cardiac troponin: hype, help, and reality. Clin Chem. 2010 Mar; 56 (3):342-4 Epub 2009 Dec 29
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Kavsak PA, Newman AM, Ko DT, Macrae AR, Jaffe AS. The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department. Clin Biochem. 2010 Mar; 43(4-5):505-7. Epub 2009 Nov 10.
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Roger VL, Weston SA, Gerber Y, Killian JM, Dunlay SM, Jaffe AS, Bell MR, Kors J, Yawn BP, Jacobsen SJ. Trends in incidence, severity, and outcome of hospitalized myocardial infarction. Circulation. 2010 Feb 23; 121 (7):863-9 Epub 2010 Feb 08
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Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Jaffe AS, Katus HA. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem. 2010 Feb; 56(2):254-61. Epub 2009 Dec 03.
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Cullen L, Than M, Brown AF, Richards M, Parsonage W, Flaws D, Hollander JE, Christenson RH, Kline JA, Goodacre S, Jaffe AS. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas. 2010 Feb; 22(1):35-55. Epub 2010 Feb 04.
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Schulz O, Reinicke M, Berghoefer GH, Bensch R, Kraemer J, Schimke I, Jaffe AS. Erratum to High-sensitive cardiac troponin I (hs-cTnl) values in patients with stable cardiovascular disease: An initial foray [Clinica Chimica Acta., 411, (2010), 812-817]. Clin Chim Acta. 2010; 411(17-18):1395-6.
Hallen J, Buser P, Schwitter J, Petzelbauer P, Geudelin B, Fagerland MW, Jaffe AS, Atar D. Relation of cardiac troponin I measurements at 24 and 48 hours to magnetic resonance-determined infarct size in patients with ST-elevation myocardial infarction. Am J Cardiol. 2009 Dec 1; 104(11):1472-7. Epub 2009 Oct 14.
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Frye RL, Simari RD, Gersh BJ, Burnett JC, Brumm S, Myerle K, Jaffe AS, Holmes DR, Lerman A, Terzic A. Ethical issues in cardiovascular research involving humans. Circulation. 2009 Nov 24; 120 (21):2113-21
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Miller WL, Hartman KA, Burritt MF, Grill DE, Jaffe AS. Profiles of serial changes in cardiac troponin T concentrations and outcome in ambulatory patients with chronic heart failure. J Am Coll Cardiol. 2009 Oct 27; 54 (18):1715-21
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Saenger AK, Dalenberg DA, Bryant SC, Grebe SK, Jaffe AS. Pediatric brain natriuretic peptide concentrations vary with age and sex and appear to be modulated by testosterone. Clin Chem. 2009 Oct; 55 (10):1869-75 Epub 2009 Aug 13
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Kavsak PA, Wang X, Ko DT, MacRae AR, Jaffe AS. Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population. Clin Chem. 2009 Oct; 55(10):1809-15. Epub 2009 Aug 13.
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Saenger AK, Lockwood C, Snozek CL, Milz TC, Karon BS, Scott MG, Jaffe AS. Catecholamine interference in enzymatic creatinine assays. Clin Chem. 2009 Sep; 55 (9):1732-6 Epub 2009 July 09
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Miller WL, Burnett JC Jr, Hartman KA, Hodge DO, Giuliani I, Minard F, Larue C, Jaffe AS. Role for precursor Pro-B type natriuretic peptide in assessing response to therapy and prognosis in patients with decompensated heart failure treated with nesiritide. Clin Chim Acta. 2009 Aug; 406(1-2):119-23. Epub 2009 Jun 11.
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Berridge BR, Pettit S, Walker DB, Jaffe AS, Schultze AE, Herman E, Reagan WJ, Lipshultz SE, Apple FS, York MJ. A translational approach to detecting drug-induced cardiac injury with cardiac troponins: consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am Heart J. 2009 Jul; 158(1):21-9.
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Kavsak PA, Wang X, Henderson M, Ko DT, MacRae AR, Jaffe AS. PAPP-A as a marker of increased long-term risk in patients with chest pain. Clin Biochem. 2009 Jul; 42(10-11):1012-8. Epub 2009 Mar 25.
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Hickson LJ, El-Zoghby ZM, Lorenz EC, Stegall MD, Jaffe AS, Cosio FG. Patient survival after kidney transplantation: relationship to pretransplant cardiac troponin T levels. Am J Transplant. 2009 Jun; 9 (6):1354-61 Epub 2009 May 13
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Feng D, Syed IS, Martinez M, Oh JK, Jaffe AS, Grogan M, Edwards WD, Gertz MA, Klarich KW. Intracardiac thrombosis and anticoagulation therapy in cardiac amyloidosis. Circulation. 2009 May 12; 119(18):2490-7. Epub 2009 May 04.
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Carney RM, Freedland KE, Steinmeyer B, Blumenthal JA, de Jonge P, Davidson KW, Czajkowski SM, Jaffe AS. History of depression and survival after acute myocardial infarction. Psychosom Med. 2009 Apr; 71(3):253-9. Epub 2009 Feb 27.
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Kavsak PA, MacRae AR, Yerna MJ, Jaffe AS. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem. 2009 Mar; 55(3):573-7. Epub 2009 Jan 23.
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Bursi F, Barbieri A, Politi L, Di Girolamo A, Malagoli A, Grimaldi T, Rumolo A, Busani S, Girardis M, Jaffe AS, Modena MG. Perioperative red blood cell transfusion and outcome in stable patients after elective major vascular surgery. Eur J Vasc Endovasc Surg. 2009 Mar; 37(3):311-8. Epub 2008 Dec 25.
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Peleg A, Jaffe AS, Hasin Y. Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood. Clinica Chimica Acta. 2009; 409(1-2):85-89.
Saab PG, Bang H, Williams RB, Powell LH, Schneiderman N, Thoresen C, Burg M, Keefe F, for the ENRICHD Investigators. The impact of cognitive behavioral group training on event-free survival in patients with myocardial infarction: The ENRICHD experience. J Psycho Res. 2009; 67:45-56.
Vasile VC, Blauwet LA, Jaffe AS. Serial determination of troponin concentrations in the diagnosis of acute myocardial infarction. Heart and Metabolism. 2009; (43):27-9.
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Lett HS, Blumenthal JA, Babyak MA, Catellier DJ, Carney RM, Berkman LF, Burg MM, Mitchell P, Jaffe AS, Schneiderman N. Dimensions of social support and depression in patients at increased psychosocial risk recovering from myocardial infarction. Int J Behav Med. 2009; 16(3):248-58.
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Eggers KM, Jaffe AS, Lind L, Venge P, Lindahl B. Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making. Clin Chem. 2009 Jan; 55(1):85-92. Epub 2008 Nov 06.
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Vasile VC, Babuin L, Rio Perez JA, Alegria JR, Song LM, Chai HS, Afessa B, Jaffe AS. Long-term prognostic significance of elevated cardiac troponin levels in critically ill patients with acute gastrointestinal bleeding. Crit Care Med. 2009 Jan; 37(1):140-7.
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McConnell JP, Jaffe AS. The spin stops here: inhibition of lipoprotein-associated phospholipase A2-- a promising target but a negative initial trial? Clin Chem. 2009 Jan; 55 (1):21-3 Epub 2008 Dec 01
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Hickson LJ, Cosio FG, El-Zoghby ZM, Gloor JM, Kremers WK, Stegall MD, Griffin MD, Jaffe AS. Survival of patients on the kidney transplant wait list: relationship to cardiac troponin T. Am J Transplant. 2008 Nov; 8 (11):2352-9 Epub 2008 Sept 10
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Arruda-Olson AM, Pellikka PA, Bursi F, Jaffe AS, Santrach PJ, Kors JA, Killian JM, Weston SA, Roger VL. Left ventricular function and heart failure in myocardial infarction: impact of the new definition in the community. Am Heart J. 2008 Nov; 156 (5):810-5 Epub 2008 Sept 09
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Trockel M, Burg M, Jaffe A, Barbour K, Taylor CB. Smoking behavior postmyocardial infarction among ENRICHD trial participants: Cognitive behavior therapy intervention for depression and low perceived social support compared with care as usual. Psychosom Med. 2008 Oct; 70(8):875-82.
Thygesen K, Alpert JS, Jaffe AS, White HD. Diagnostic application of the universal definition of myocardial infarction in the intensive care unit. Curr Opin Crit Care. 2008 Oct; 14(5):543-8.
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Jaffe AS. Key issues in the developing synergism between cardiovascular imaging and biomarkers. Clin Chem. 2008 Sep; 54 (9):1432-42 Epub 2008 Aug 01
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Carney RM, Steinmeyer B, Freedland KE, Blumenthal JA, Stein PK, Steinhoff WA, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Domitrovich PP, Burg MM, Hayano J, Jaffe AS. Nighttime heart rate and survival in depressed patients post acute myocardial infarction. Psychosom Med. 2008 Sep; 70(7):757-63. Epub 2008 Aug 25.
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Prasad A, Rihal CS, Lennon RJ, Singh M, Jaffe AS, Holmes DR Jr. Significance of periprocedural myonecrosis on outcomes after percutaneous coronary intervention: an analysis of preintervention and postintervention troponin T levels in 5487 patients. Circ Cardiovasc Interv. 2008 Aug; 1(1):10-9.
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Hess EP, Thiruganasambandamoorthy V, Wells GA, Erwin P, Jaffe AS, Hollander JE, Montori VM, Stiell IG. Diagnostic accuracy of clinical prediction rules to exclude acute coronary syndrome in the emergency department setting: a systematic review. CJEM. 2008 Jul; 10(4):373-82.
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Carney RM, Freedland KE, Steinmeyer B, Blumenthal JA, Berkman LF, Watkins LL, Czajkowski SM, Burg MM, Jaffe AS. Depression and five year survival following acute myocardial infarction: a prospective study. J Affect Disord. 2008 Jul; 109(1-2):133-8. Epub 2008 Jan 11.
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Brune K, Katus HA, Moecks J, Spanuth E, Jaffe AS, Giannitsis E. N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial. Clin Chem. 2008 Jul; 54(7):1149-57. Epub 2008 May 01.
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Karon BS, Wockenfus A, Scott R, Hartman SJ, McConnell JP, Santrach PJ, Jaffe AS. Aspirin responsiveness in healthy volunteers measured with multiple assay platforms. Clin Chem. 2008 Jun; 54 (6):1060-5 Epub 2008 Apr 17
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Miller WL, Kurien S, Warfield KT, Wood CM, Jaffe AS. Lack of association between worsening renal function and mortality in heart failure patients treated with nesiritide. Int J Cardiol. 2008 May 23; 126(2):234-9. Epub 2007 May 07.
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Kavsak PA, Newman AM, Ko DT, Palomaki GE, Lustig V, MacRae AR, Jaffe AS. Is a pattern of increasing biomarker concentrations important for long-term risk stratification in acute coronary syndrome patients presenting early after the onset of symptoms? Clin Chem. 2008 Apr; 54(4):747-51.
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Kavsak PA, Ko DT, Newman AM, Lustig V, Palomaki GE, MacRae AR, Jaffe AS. Vascular versus myocardial dysfunction in acute coronary syndrome: are the adhesion molecules as powerful as NT-proBNP for long-term risk stratification? Clin Biochem. 2008 Apr; 41(6):436-9. Epub 2007 Dec 27.
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Lopez-Jimenez F, Wu CO, Tian X, O'Connor C, Rich MW, Burg MM, Sheps D, Raczynski J, Somers VK, Jaffe AS. Weight change after myocardial infarction--the Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) experience. Am Heart J. 2008 Mar; 155 (3):478-84 Epub 2008 Jan 15
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Babuin L, Vasile VC, Rio Perez JA, Alegria JR, Chai HS, Afessa B, Jaffe AS. Elevated cardiac troponin is an independent risk factor for short- and long-term mortality in medical intensive care unit patients. Crit Care Med. 2008 Mar; 36(3):759-65.
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Wu AH, Jaffe AS. The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing. Am Heart J. 2008 Feb; 155(2):208-14. Epub 2007 Dec 19.
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Giannitsis E, Steen H, Kurz K, Ivandic B, Simon AC, Futterer S, Schild C, Isfort P, Jaffe AS, Katus HA. Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T. J Am Coll Cardiol. 2008 Jan 22; 51(3):307-14.
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Miller WL, Jaffe AS. Serial biomarker measurements in chronic heart failure. Cardiology Review. 2008; 25(3):53-8.
Kavsak PA, Ko DT, Newman AM, Palomaki GE, Lustig V, Macrae AR, Jaffe AS. "Upstream markers" provide for early identification of patients at high risk for myocardial necrosis and adverse outcomes. Clin Chim Acta. 2008 Jan; 387(1-2):133-8. Epub 2007 Oct 03.
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Miller WL, Targonski PV, Jaffe AS. B-type natriuretic peptides in heart failure: update on clinical applications and limitations. Biomark Med. 2007 Dec; 1(4):503-12.
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Kavsak PA, Ko DT, Newman AM, Palomaki GE, Lustig V, MacRae AR, Jaffe AS. Risk stratification for heart failure and death in an acute coronary syndrome population using inflammatory cytokines and N-terminal pro-brain natriuretic peptide. Clin Chem. 2007 Dec; 53(12):2112-8. Epub 2007 Oct 11.
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Feng D, Edwards WD, Oh JK, Chandrasekaran K, Grogan M, Martinez MW, Syed II, Hughes DA, Lust JA, Jaffe AS, Gertz MA, Klarich KW. Intracardiac thrombosis and embolism in patients with cardiac amyloidosis. Circulation. 2007 Nov 20; 116(21):2420-6.
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Lee-Lewandrowski E, Januzzi JL, Green SM, Tannous B, Wu AH, Smith A, Wong A, Murakami MM, Kaczmarek J, Apple FS, Miller WL, Hartman K, Jaffe AS. Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay. Clin Chim Acta. 2007 Nov-Dec; 386(1-2):20-4. Epub 2007 Jul 25.
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Schulz O, Paul-Walter C, Lehmann M, Abraham K, Berghoefer G, Schimke I, Jaffe AS. Usefulness of detectable levels of troponin, below the 99th percentile of the normal range, as a clue to the presence of underlying coronary artery disease. Am J Cardiol. 2007 Sep 1; 100(5):766-71.
Binder J, Ommen SR, Chen HH, Ackerman MJ, Tajik AJ, Jaffe AS. Usefulness of brain natriuretic peptide levels in the clinical evaluation of patients with hypertrophic cardiomyopathy. Am J Cardiol. 2007 Aug 15; 100: (4)712-4.
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Ting HH, Rihal CS, Gersh BJ, Haro LH, Bjerke CM, Lennon RJ, Lim CC, Bresnahan JF, Jaffe AS, Holmes DR, Bell MR. Regional systems of care to optimize timeliness of reperfusion therapy for ST-elevation myocardial infarction: the Mayo Clinic STEMI Protocol. Circulation. 2007 Aug 14; 116(7):729-36. Epub 2007 Aug 01.
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Ghearing GR, Munger TM, Jaffe AS, Benarroch EE, Britton JW. Clinical cues for detecting ictal asystole. Clin Auton Res. 2007 Aug; 17 (4):221-6 Epub 2007 July 16
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Lett HS, Blumenthal JA, Babyak MA, Catellier DJ, Carney RM, Berkman LF, Burg MM, Mitchell P, Jaffe AS, Schneiderman N. Social support and prognosis in patients at increased psychosocial risk recovering from myocardial infarction. Health Psychol. 2007 Jul; 26(4):418-27.
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Saenger AK, Jaffe AS. The use of biomarkers for the evaluation and treatment of patients with acute coronary syndromes. Med Clin North Am. 2007 Jul; 91: (4)657-81; xi.
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Miller WL, Hartman KA, Burritt MF, Burnett JC Jr, Jaffe AS. Troponin, B-type natriuretic peptides and outcomes in severe heart failure: differences between ischemic and dilated cardiomyopathies. Clin Cardiol. 2007 May; 30 (5):245-50
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Kavsak PA, MacRae AR, Newman AM, Lustig V, Palomaki GE, Ko DT, Tu JV, Jaffe AS. Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clin Chim Acta. 2007 May 1; 380(1-2):213-6. Epub 2007 Jan 23.
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Kavsak PA, MacRae AR, Newman AM, Lustig V, Palomaki GE, Ko DT, Tu JV, Jaffe AS. Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure. Clin Biochem. 2007 Mar; 40(5-6):326-9.
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Friedewald VE, Arnold LW, Carney RM, Jaffe AS, Sheps DS, Roberts WC. The Editor's Roundtable: major depression in patients with coronary heart disease. Am J Cardiol. 2007 Feb 15; 99(4):519-29.
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Kavsak PA, Newman AM, Lustig V, MacRae AR, Palomaki GE, Ko DT, Tu JV, Jaffe AS. Long-term health outcomes associated with detectable troponin I concentrations. Clin Chem. 2007 Feb; 53(2):220-7. Epub 2007 Jan 04.
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Carney RM, Howells WB, Blumenthal JA, Freedland KE, Stein PK, Berkman LF, Watkins LL, Czajkowski SM, Steinmeyer B, Hayano J, Domitrovich PP, Burg MM, Jaffe AS. Heart rate turbulence, depression, and survival after acute myocardial infarction. Psychosom Med. 2007 Jan; 69(1):4-9. Epub 2006 Dec 13.
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Kavsak PA, MacRae AR, Palomaki GE, Newman AM, Ko DT, Lustig V, Tu JV, Jaffe AS. Health outcomes categorized by current and previous definitions of acute myocardial infarction in an unselected cohort of troponin-naive emergency department patients. Clin Chem. 2006 Nov; 52(11):2028-35. Epub 2006 Sep 21.
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Gerber Y, McConnell JP, Jaffe AS, Weston SA, Killian JM, Roger VL. Lipoprotein-associated phospholipase A2 and prognosis after myocardial infarction in the community. Arterioscler Thromb Vasc Biol. 2006 Nov; 26: (11)2517-22.
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Roger VL, Killian JM, Weston SA, Jaffe AS, Kors J, Santrach PJ, Tunstall-Pedoe H, Jacobsen SJ. Redefinition of myocardial infarction: prospective evaluation in the community. Circulation. 2006 Aug 22; 114(8):790-7. Epub 2006 Aug 14.
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Kavsak PA, MacRae AR, Lustig V, Bhargava R, Vandersluis R, Palomaki GE, Yerna MJ, Jaffe AS. The impact of the ESC/ACC redefinition of myocardial infarction and new sensitive troponin assays on the frequency of acute myocardial infarction. Am Heart J. 2006 Jul; 152(1):118-25.
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Rana R, Vlahakis NE, Daniels CE, Jaffe AS, Klee GG, Hubmayr RD, Gajic O. B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema. Crit Care Med. 2006 Jul; 34(7):1941-6.
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Nigam A, Wright RS, Allison TG, Williams BA, Kopecky SL, Reeder GS, Murphy JG, Jaffe AS. Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death. Int J Cardiol. 2006 Jun 16; 110 (2):153-9 Epub 2005 July 25
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Miller WL, Garratt KN, Burritt MF, Lennon RJ, Reeder GS, Jaffe AS. Baseline troponin level: key to understanding the importance of post-PCI troponin elevations. Eur Heart J. 2006 May; 27(9):1061-9. Epub 2006 Feb 15.
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Macrae AR, Kavsak PA, Lustig V, Bhargava R, Vandersluis R, Palomaki GE, Yerna MJ, Jaffe AS. Assessing the requirement for the 6-hour interval between specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies. Clin Chem. 2006 May; 52(5):812-8. Epub 2006 Mar 23.
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Wright RS, Bybee K, Miller WL, Laudon DA, Murphy JG, Jaffe AS. Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI. Int J Cardiol. 2006 Apr 14; 108(3):314-9. Epub 2005 Jun 22.
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Williams BA, Wright RS, Murphy JG, Brilakis ES, Reeder GS, Jaffe AS. A new simplified immediate prognostic risk score for patients with acute myocardial infarction. Emerg Med J. 2006 Mar; 23 (3):186-92
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Maramattom BV, Manno EM, Fulgham JR, Jaffe AS, Wijdicks EF. Clinical importance of cardiac troponin release and cardiac abnormalities in patients with supratentorial cerebral hemorrhages. Mayo Clin Proc. 2006 Feb; 81(2):192-6.
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Rana R, Vlahakis NE, Daniels CE, Jaffe AS, Klee GG, Hubmayr RD, Gajic O. Uitlity of Early Measurement of Plasma B Type Natriuretic Peptide in the Assessment of Acute Lung Injury and Cardiogenic Pulmonary Edema. Critical Care Medicine. 2006; 33(12):A20.
Miller WL, Edwards BS, Kremers WK, Kushwaha SS, McGregor CGA, Daly RC, Jaffe AS. Elevated donor troponin levels are associated with a lower frequency of allograft vasculopathy. J Heart Lung Transplant. 2005 Dec; 24(12):2075-8.
Babuin L, Jaffe AS. Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ. 2005 Nov 8; 173 (10):1191-202
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Apple FS, Parvin CA, Buechler KF, Christenson RH, Wu AHB, Jaffe AS. Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction. Clin Chem. 2005 Nov; 51(11):2198-200.
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Bursi F, Babuin L, Barbieri A, Politi L, Zennaro M, Grimaldi T, Rumolo A, Gargiulo M, Stella A, Modena MG, Jaffe AS. Vascular surgery patients: perioperative and long-term risk according to the ACC/AHA guidelines, the additive role of post-operative troponin elevation. Eur Heart J. 2005 Nov; 26(22):2448-56.
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Jaffe AS. Use of biomarkers in the emergency department and chest pain unit. Cardiol Clin. 2005 Nov; 23(4):453-65, vi.
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Gheorghiade M, Stough WG, Adams KF, Jaffe AS, Hasselblad V, O'Connor CM. The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF). Am J Cardiol. 2005 Sep 19; 96: (6A Suppl S)18G-25G.
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Miller WL, Burnett JC Jr, Hartman KA, Henle MP, Burritt MF, Jaffe AS. Lower rather than higher levels of B-type natriuretic peptides (NT-pro-BNP and BNP) predict short-term mortality in end-stage heart failure patients treated with nesiritide. Am J Cardiol. 2005 Sep 15; 96(6):837-41.
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Carney RM, Blumenthal JA, Freedland KE, Stein PK, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Domitrovich PP, Jaffe AS. Low heart rate variability and the effect of depression on post-myocardial infarction mortality. Arch Intern Med. 2005 Jul 11; 165(13):1486-91.
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Taylor CB, Youngblood ME, Catellier D, Veith RC, Carney RM, Burg MM, Kaufmann PG, Shuster J, Mellman T, Blumenthal JA, Krishnan R, Jaffe AS. Effects of antideressant medication of morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry. 2005 Jul; 62(7):792-8.
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Apple FS, Wu AHB, Mair J, Ravkilde J, Panteghini M, Tate J, Pagani F, Christenson RH, Mockel M, Danne O, Jaffe AS. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem. 2005 May; 51(5):810-24.
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Miller WL, Hartman KA, Burritt MF, Borgeson DD, Burnett JC Jr, Jaffe AS. Biomarker responses during and after treatment with nesiritide infusion in patients with decompensated chronic heart failure. Clin Chem. 2005 Mar; 51 (3):569-77 Epub 2004 Dec 22
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Apple FS, Panteghini M, Ravkilde J, Mair J, Wu AHB, Tate J, Pagani F, Christenson RH, Jaffe AS. Quality specifications for B-type natriuretic peptide assays. Clin Chem. 2005 Mar; 51(3):486-93.
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Gibler WB, Cannon CP, Blomkalns AL, Char DM, Drew BJ, Hollander JE, Jaffe AS, Jesse RL, Newby LK, Ohman EM, Peterson ED, Pollack CV. Practical implementation of the guidelines for unstable angina/non-st-segment elevation myocardial infarction in the emergency department. Circulation. 2005; 111:2699-2710.
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Gibler WB, Cannon CP, Blomkalns AL, Char DM, Drew BJ, Hollander JE, Jaffe AS, Jesse RL, Newby LK, Ohman EM, Peterson ED, Pollack CV. Practical Implementation of the guidelines for unstable angina/non-st-segment elevation myocardial infarction in the emergency department. Ann Emergency Med..2005,Aug;46:(2):185-197.
Gibbons RJ, Valeti US, Araoz PA, Jaffe AS. The quantification of infarct size. J Am Coll Cardiol. 2004 Oct 19; 44(8):1533-42.
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Gulati M, Patel S, Jaffe AS, Joseph AJ, Calvin JE. Impact of contemporary guideline compliance on risk stratification models for acute coronary syndromes in the registry of acute coronary syndromes. Am J Cardiol. 2004 Oct 1; 94(7):873-8.
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Perez EA, Suman VJ, Davidson NE, Kaufman PA, Martino S, Dakhil SR, Ingle JN, Rodeheffer RJ, Gersh BJ, Jaffe AS. Effect of doxorubicin plus cyclophosphamide on left ventricular ejection fraction in patients with breast cancer in the North Central Cancer Treatment Group N9831 Intergroup Adjuvant Trial. J Clin Oncol. 2004 Sep 15; 22(18):3700-4.
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Dispenzieri A, Gertz MA, Kyle RA, Lacy MQ, Burritt MF, Therneau TM, McConnell JP, Litzow MR, Gastineau DA, Tefferi A, Inwards DJ, Micallef IN, Ansell SM, Porrata LF, Elliott MA, Hogan WJ, Rajkumar SV, Fonseca R, Greipp PR, Witzig TE, Lust JA, Zeldenrust SR, Snow DS, Hayman SR, McGregor CG, Jaffe AS. Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2004 Sep 15; 104 (6):1881-7 Epub 2004 Mar 25
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Dispenzieri A, Gertz MA, Kyle RA, Lacy MQ, Burritt MF, Therneau TM, Greipp PR, Witzig TE, Lust JA, Rajkumar SV, Fonseca R, Zeldenrust SR, McGregor CG, Jaffe AS. Serum cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis. J Clin Oncol. 2004 Sep 15; 22 (18):3751-7
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Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS. Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol. 2004 Aug 1; 94 (3):343-6
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Carney RM, Blumenthal JA, Freedland KE, Youngblood M, Veith RC, Burg MM, Cornell C, Saab PG, Kaufmann PG, Czajkowski SM, Jaffe AS. Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosom Med. 2004 Jul-Aug; 66(4):466-74.
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Schneiderman N, Saab PG, Catellier DJ, Powell LH, DeBusk RF, Williams RB, Carney RM, Raczynski JM, Cowan MJ, ENRICHD. Psychosocial treatment within sex by ethnicity subgroups in the enhancing recovery in coronary heart disease clinical trial Psychosomatic Medicine.2004;66:(4)475-483.
La Vecchia L, Ottani F, Favero L, Spadaro GL, Rubboli A, Boanno C, Mezzena G, Fontanelli A, Jaffe AS. Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism. Heart (British Cardiac Society). 2004 Jun; 90: (6)633-7.
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Gami AS, Svatikova A, Wolk R, Olson EJ, Duenwald CJ, Jaffe AS, Somers VK. Cardiac troponin T in obstructive sleep apnea. Chest. 2004 Jun; 125 (6):2097-100
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Gami AS, Jaffe AS. 60-year-old man with chest pain. Mayo Clin Proc. 2004 Mar; 79(3):399-402.
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Miller WL, Garratt KN, Burritt MF, Reeder GS, Jaffe AS. Timing of peak troponin T and creatine kinase-MB elevations after percutaneous coronary intervention. Chest. 2004 Jan; 125 (1):275-80
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Carney RM, Blumenthal JA, Catellier D, Freedland KE, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Jaffe AS. Depression as a risk factor for mortality after acute myocardial infarction. Am J Cardiol. 2003 Dec 1; 92(11):1277-81.
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Luepker RV, Apple FS, Christenson RH, Crow RS, Fortmann SP, Goff D, Goldberg RJ, Hand MM, Jaffe AS, Julian DG, Levy D, Manolio T, Mendis S, Mensah G, Pajak A, Prineas RJ, Reddy KS, Roger VL, Rosamond WD, Shahar E, Sharrett AR, Sorlie P, Tunstall-Pedoe H. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; theEuropean Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation. 2003 Nov 18; 108(20):2543-9.
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Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, Czajkowski SM, DeBusk R, Hosking J, Jaffe A, Kaufmann PG, Mitchell P, Norman J, Powell LH, Raczynski JM, Schneiderman N. Effects of treating depression and low-perceived social support on clinical events after myocardial infarction - The enhancing recovery in coronary heart disease patients (ENRICHD) randomized trial. JAMA: Journal of the American Medical Association. 2003 Jun 18; 289(23):3106-16.
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Woodruff BK, Britton JW, Tigaran S, Cascino GD, Burritt MF, McConnell JP, Ravkilde J, Molgaard H, Andreasen F, Dam M, Jaffe AS. Cardiac troponin levels following monitored epileptic seizures. Neurology. 2003 May 27; 60 (10):1690-2
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Dispenzieri A, Kyle RA, Gertz MA, Therneau TM, Miller WL, Chandrasekaran K, McConnell JP, Burritt MF, Jaffe AS. Survival in patients with primary systemic amyloidosis and raised serum cardiac troponins. Lancet. 2003 May 24; 361 (9371):1787-9
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Carney RM, Freedland KE, Stein PK, Watkins LL, Catellier D, Jaffe AS, Yeragani VK. Effects of depression on QT interval variability after myocardial infarction. Psychosom Med. 2003 Mar-Apr; 65(2):177-80.
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Tigaran S, Molgaard H, McClelland R, Dam M, Jaffe AS. Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients. Neurology. 2003 Feb 11; 60(3):492-5.
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Gheorghiade M, Gattis WA, Adams KF, Jaffe AS, O'Connor CM. Rationale and design of the Pilot Randomized Study of Nesiritide versus Dobutamine in Heart Failure (PRESERVD-HF). Am Heart J. 2003 Feb; 145(2 Suppl S):S55-7.
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Freedland KE, Rich MW, Skala JA, Carney RM, Davila-Roman VG, Jaffe AS. Prevalence of depression in hospitalized patients with congestive heart failure. Psychosom Med. 2003 Jan-Feb; 65(1):119-28.
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Apple FS, Wu AHB, Jaffe AS. European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: How to use existing assays clinically and for clinical trials. Am Heart J. 2002 Dec; 144(6):981-6.
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Aviles RJ, Wright RS, Aviles JM, McDonald F, Ballman K, Harker-Murray A, Scott C, Lauer MS, Kopecky SL, Jaffe AS. Long-term prognosis of patients with clinical unstable angina pectoris without elevation of creatine kinase but with elevation of cardiac troponin i levels. Am J Cardiol. 2002 Oct 15; 90 (8):875-8
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Carney RM, Freedland KE, Miller GE, Jaffe AS. Depression as a risk factor for cardiac mortality and morbidity - A review of potential mechanisms. J Psychosom Res. 2002 Oct; 53(4):897-902.
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Wright RS, Reeder GS, Herzog CA, Albright RC, Williams BA, Dvorak DL, Miller WL, Murphy JG, Kopecky SL, Jaffe AS. Acute myocardial infarction and renal dysfunction: a high-risk combination. Ann Intern Med. 2002 Oct 1; 137 (7):563-70
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Wright RS, Williams BA, Cramner H, Gallahue F, Willmore T, Lewis L, Ladenson JH, Jaffe AS. Elevations of cardiac troponin I are associated with increased short-term mortality in noncardiac critically ill emergency department patients. Am J Cardiol. 2002 Sep 15; 90 (6):634-6
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Carlson RJ, Navone A, McConnell JP, Burritt M, Castle MC, Grill D, Jaffe AS. Effect of myocardial ischemia on cardiac troponin I and T. Am J Cardiol. 2002 Jan 15; 89(2):224-6.
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Cantwell RV, Aviles RJ, Bjornsson J, Wright RS, Freeman WK, Oh JK, Hoyer JD, Markovic S, Jaffe AS. Cardiac amyloidosis presenting with elevations of cardiac troponin I and angina pectoris. Clin Cardiol. 2002 Jan; 25 (1):33-7
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McConnell JP, Branum EL, Ballman KV, Lagerstedt SA, Katzmann JA, Jaffe AS. Gender differences in C-reactive protein concentrations-confirmation with two sensitive methods. Clin Chem Lab Med. 2002 Jan; 40: (1)56-9.
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Jaffe AS, World Health Organization//European Society of Cardiology//American College of Cardiology. New standard for the diagnosis of acute myocardial infarction. Cardiol Rev. 2001 Nov-Dec; 9 (6):318-22
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Miller WL, Wright RS, McGregor CG, Dispenzieri A, McConnell JP, Burritt MF, Jaffe AS. Troponin levels in patients with amyloid cardiomyopathy undergoing cardiac transplantation. Am J Cardiol. 2001 Oct 1; 88 (7):813-5
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Jaffe AS, ENRICHD Investigators. Enhancing Recovery in coronary heart disease (ENRICHD) study intervention: Rationale and design Psychosom Med.2001;63:(5)747-755.
Antman EM, Corbalan R, Huber K, Jaffe AS. Issues in early risk stratification for UA/NSTEMI. European Heart Journal Supplement. 2001 Aug; 3(J):J6-J14.
Jaffe AS. Diagnosis of Acute Myocardial Infarction: The Use of Troponin Markers. Israeli Heart Journal. 2001.
Jacobs I, Callanan V, Nichol G, Valenzuela T, Mason P, Jaffe AS, Landau W, Vetter N. The Chain of Survival. Annals of Emergency Medicine/Journal of the American College of Emergency Physicians S5 2001; 37(4).
Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, Czajkowski SM, DeBusk R, Hosking J, Jaffe A, Kaufmann PG, Mitchell P, Norman J, Powell LH, Raczynski JM, Schneiderman N. The ENRICHD Investigators. Enhancing Recovery in Coronary Heart Disease (ENRICHD): Baseline Characteristics. Amer J Card. 2001; 88:316-22.
Jaffe AS. Elevations in cardiac troponin measurements: false false-positives: the real truth. Cardiovasc Toxicol. 2001; 1 (2):87-92
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Ottani F, Galvani M, Nicolini FA, Ferrini D, Pozzati A, Di Pasquale G, Jaffe AS. Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J. 2000 Dec; 140(6):917-27.
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Dixit S, Castle M, Velu RP, Swisher L, Hodge C, Jaffe AS. Cardiac involvement in patients with acute neurologic disease: confirmation with cardiac troponin I. Arch Intern Med. 2000 Nov 13; 160 (20):3153-8
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Carney RM, Freedland KE, Stein PK, Skala JA, Hoffman P, Jaffe AS. Change in heart rate and heart rate variability during treatment for depression in patients with coronary heart disease. Psychosom Med. 2000 Sep-Oct; 62(5):639-47.
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Alpert JS, Antman E, Apple F, Armstrong PW, Bassand JP, de Luna G, Breithardt G, Chaitman BR, Clemmensen P, Falk E, Fishbein MC, Galvani M, Garson A, Grines C, Hamm C, Jaffe AS, Katus H, Kjekshus J, Klein W, Klootwijk P, Lenfant C, Levy D, Levy RI, Luepker R, et al. Myocardial infarction redefined - A consensus document of the Joint European Society of cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Journal of the American College of Cardiology. 2000 Sep; 36(3):959-69.
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Hutter AM, Amsterdam EA, Jaffe AS. Task force 2: acute coronary syndromes: Section 2B - chest discomfort evaluation in the hospital. J Am Coll Cardiol. 2000 Mar 15; 35(4):853-862.
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Stein PK, Carney RM, Freedland KE, Skala JA, Jaffe AS, Kleiger RE, Rottman JN. Severe depression is associated with markedly reduced heart rate variability in patients with stable coronary heart disease. Journal of Psychosomatic Research. 2000; 48:493-500.
Freedland KE, Skala JA, Carney RM, Stein PK, Hoffman P, Jaffe AS. Prevalence of depression in hospitalized patients with congestive heart failure. Psychosom Med.2000;62:(5):639-647.
Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, Czajkowski SM, DeBusk R, Hosking J, Jaffe A, Kaufmann PG, Mitchell P, Norman J, Powell LH, Raczynski JM, Schneiderman N. Enhancing recovery in coronary heart disease (ENRICHD) patients study: Study design and methods. American Heart Journal. 2000; 139:1-9.
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Carney RM, Freedland KE, Veith RC, Cryer PE, Skala JA, Lynch T, Jaffe AS. Major depression, heart rate, and plasma norepinephrine in patients with coronary heart disease. Biol Psychiatry. 1999 Feb 15; 45(4):458-63.
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Ottani F, Galvani M, Ferrini D, Ladenson JH, Puggioni R, Destro A, Baccos D, Bosi S, Ronchi A, Rusticali, Jaffe AS. Direct comparison of early elevations of cardiac troponin T and I in patients with unstable angina. AHJ. 1999; 137:284-91.
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Carney RM, Freedland EK, Veith RC, Jaffe AS. Can treating depression reduce mortality after an acute myocardail infarction? Psychosomatic Medicine. 1999; 61:666-75.
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Jaffe AS. 2001--a biomarker odyssey. Clin Chim Acta. 1999 Jun 30;284(2):197-211.
Jaffe AS. The use of troponin measurements in patients with unstable angina. International Journal of Cardiology. 1999; 1: (68 Suppl)S49-53.
Carney RM, Freedland KE, Eisen SA, Rich MW, Skala JA, Jaffe AS. Adherence to a prophyllactic medication regimen in patients with symptomatic vs asymptomatic ischemic heart disease Behavioral Medicine. 1998; 24:35-9.
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Landt M, Lawson GM, Helgeson JM, Davila-Roman VG, Ladenson JH, Jaffe AS, Hickner RC. Prolonged exercise decreases serum leptin concentrations. Metabolism: Clinical & Experimental. 1997 Oct; 46(10):1109-12.
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Selis SP, Hom M, Sequeira JM, Tritel M, Gindea A, Ladenson JH, Jaffe AS, Esposito R. Time course of lysophosphatydylcholine relase from ischemic human myocardium parallels the time course of early ischemic ventricular arrhythmia Coron Art Disease. 1997; 8:19-27.
Davila-Roman V, Guest TH, Tuteur PG, Rowe WJ, Ladenson JH, Jaffe AS. Transient right but not left ventricular dysfunction after strenuous exercise at high altitude JACC. 1997; 30:468-73.
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Smith SC, Ladenson JH, Mason JW, Jaffe AS. Elevations of cardiac troponin I associated with myocarditis: Experimental and clinical correlates Circulation. 1997; 95:163-8.
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Hirsch R, Landt Y, Porter S, Canter CE, Jaffe AS, Ladenson JH, Grant JW, Landt M. Cardiac troponin I in Pediatrics: Normal values and potential use in the assessment of cardiac injury J Peds. 1997; 130:827-72.
Galvani M, Ottani F, Ferrini D, Ladenson JH, Destro A, Baccos D, Rusticali F, Jaffe AS. Prognostic influence of elevated values of cardiac troponin I in patients with unstable angina. Circulation. 1997; 95:2053-9.
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Allan JJ, Feld RD, Russell AA, Ladenson JH, Rogers MAM, Kerber RI, Jaffe AS. Cardiac troponin I levels are normal or minimally elevated after transthoracic cardioversion JACC. 1997; 30:1052-6.
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Jaffe AS. More rapid diagnosis of myocardial infarction: Is it worthwhile? American Family Physician. 1997; 55:2591-2594.
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Adams JE, Davila-Roman VG, Bessey PQ, Blake DP, Ladenson JH, Jaffe AS. Improved detection of cardiac contusion with cardiac troponin I Am Heart J. 1996; 131:308-12.
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Jaffe AS, Landt Y, Parvin CA, Abendschein DR, Geltman EM, Ladenson JH. Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for the diagnosing acute myocardial infarction Clin Chem. 1996; 42:1770-6.
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Jaffe AS. Rationale for the use of conjunctive anticoagulation during thrombolysis. In Review in Depth Sobel BE Coron Art Dis. 1996; 7:491-6.
Carney RM, Freedland KE, Rich MW, Jaffe AS. Depression as a risk factor for cardiac events in established coronary heart disease: A review of possible mechanisms. Ann Behav Med. 1995 Spring; 17(2):142-9.
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Guest TM, Ramanathan AV, Schechtman KB, Ladenson JH, Jaffe AS. Myocardial injury in critically ill medical patients: A surprisingly frequent complication JAMA 49 1995. 1995; 273: 1945-9.
Carney RM, Freedland KE, Eisen SA, Rich MW, Jaffe AS. Major depression and medication adherence in elderly patients with coronary artery disease Health Psychology. 1995; 14:88-90.
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Carney RM, Saunders RD, Freedland KE, Stein P, Rich MW, Jaffe AS. Association of depression with reduced heart rate variability in coronary artery disease AJC. 1995; 76:562-4.
Lenke LG, Bridwel KH, Jaffe AS. Increase inc reatine kinase MB isoenzyme levels and spinal surgery J Spinal Disorders. 1994; 7:70-6.
Adams JE III, Schechtman K, Landt V, Landenson JH, Jaffe AS. Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I Clin Chem 7. 1994; 40: 1291-5.
Jaffe AS, Eisenberg PR, Abendschein DR. Conjoint use of MM and MB creatine kinase isoforms for detection of coronary recanalization Am Heart J. 1994; 127:1461-6.
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Adams JE, Sicard G, Allan BT, Bridwell KH, Lenke LG, Davila-Roman VG, Bodor GS, Ladenson JH, Jaffe AS. Diagnosis of perioperative myocardial infarction with masurement of cardiac troponin I N Engl J Med. 1994; 330:670-4.
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Grant JW, Canter CE, Spray TL, Landt Y, Saffitz JE, Ladenson JH, Jaffe AS. Elevated donor cardiac troponin I: A marker of acute graft failure in infant heart recipients Circulation. 1994; 90:2618-21.
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Adams JE III, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation. 1993 Jul; 88(1):101-6.
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Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL. Hemodynamic effects of atrial ineraction Cor ARt Dis. 1993; 4:545-53.
Carney RM, Freedland KE, Rich MW, Smith LJ, Jaffe AS. Ventricular tachycardia and psychiatric depression in patients with coronary artery disease Am J Med. 1993; 95:23-8.
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Eisenberg MS, Aghababian RV, Bossaert L, Jaffe AS, Ornato JP, Weaver WD:. Thrombolytic therapy. Ann Emerg Med. 1993; 22:417-27.
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Adams JE, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury: Is MB creatine kinase the choice for the 1990's? Circulation. 1993; 88:750-63.
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Jaffe AS, Landau WM:. Clinical neuromythology XI death after death: The presumption of informed consent for CPR, ethical paradox, clinical conundrum. Neurology. 1993; 43:2173-8.
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Jaffe AS. The use of antiarrhythmias in advanced cardiac life support. Ann Emerg Med. 1993; 22:307-16.
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Jaffe AS, Deedwania PC, Higginson LA, Boden WE, Mehta JL, Ferlinz J, Walsh RA, Sullivan JM, Vokonas PS, Cabin H, et al. Diagnostic and therapeutic implications: exploration through case discussions. Am J Cardiol. 1992 Nov 16; 70(16):45F-48F.
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Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL. Importance of LV function and systolic ventricular interaction to right ventricular performance during acute right heart ischemia JACC. 1992; 19:704-11.
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Adams JE, Siegel BA, Goldstein JA, Jaffe AS. Elevations of CK-MB following pulmonary embolism: A manifestation of occult right ventricular infarction Chest. 1992; 101:1203-6.
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Goldstein JA, Kenzora JL, Jaffe AS. Coronary angiography with a novel mobile x-ray image intensifier Coronary ARtery Dis. 1992; 3:1065-71.
Carney RM, Freedland KE, Clark KA, Skala JA, Smith L, Delamater A, Jaffe AS. Psychosocial adjustment of patients arriving early at the emergency department after acute myocardial infarction Am J Cardiol. 1992; 69:160-2.
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Prager NA, Suzuki T, Jaffe AS, Sobel BE, Abendschein DR. The nature and time course of generation of isoforms of MB creatine kinase in vivo JACC. 1992; 20:414-9.
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Eisenberg PR, Sobel BE, Jaffe AS. Activation of prothrombin accompanying thrombolysis with rt-PA JACC. 1992; 19:1065-9.
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Freedland KE, Carney RM, Lustman PJ, Rich MW, Jaffe AS. Major depression in coronary artery disease, patients with versus without a prior history of depression Psychosomatic Med. 1992; 54:416-21.
Jaffe AS, Emergency Cardiac Ca. Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care JAMA. 1992; 268:2171-81.
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Jaffe AS. The use of intravenous diltiazem in patients with acute coronary artery disease. Am J Cardiol. 1992; 69:25B-9B.
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Jaffe AS. Effects of diabetes on the heart. (Overview) Cor Artery Dis. 1992; 3:1-3.
Hartwell TD, Parker CB, Poole WK, Davis VG, Muller JE, Braunwald E, Robertson T, Rutherford J, Sobel BE, Strauss W, Thomas L, Roberts R, Jaffe AS, Willerson JT. Reproducibility of centralized laboratory interpretations of measures of myocardial infarct size, ventricular function, and ventricular electrical instability scintigraphy Coronary ARtery Disease.1991;2:(9):997-984.
Atkins JM, Mentzer RM, Field JM, Ornato JP, Francis CK, Passamani ER, Gibson RS, Prediman KS, Goldberg SJ, Smith HC, et al. Recommended guidelines for in-hospital cardiac monitoring of adults for detection of arrhythmia. Am Coll Cardiol. 1991; 18(6):1431-3.
Carney RM, Freedland KE, Jaffe AS. Altered circadian variation of acute myocardial infarction in patients with depression Coronary Artery Disease. 1991; 2:61-5.
Scharp DW, Lacy PE, Santiago JV, McCullough CS, Weide LG, Boyle PJ, Falqui L, Marchetti P, Ricordi C, Gingerich RL, Jaffe AS, Cryer PE, Hanto DW, Anderson CB, Flye MW. Results of our first nine intraportal islet allografts in type I insulin dependent diabetic patients Transplantation. 1991; 51:76-85.
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Abendschein DA, Ellis AK, Eisenberg PR, Klocke FJ, Sobel BE, Jaffe AS. Prompt detection of coronary recanalization by analysis of rates of change of concentrations of macromolecular markers in plasma Cor ARt Dis. 1991; 2:201-12.
Eisenberg PR, Kenzora J, Sobel BE, Ludbrook PA, Jaffe AS. Relation between ST segment shifts during ischemia and thrombin activity in patients with unstable angina JACC. 1991; 18:893-903.
Goldstein JA, Tweddell JS, Barzilai B, Yagi Y, Jaffe AS, Cox JL. Right atrial ischemia exacerbates hemodynamic compromise associated with experimental right ventricular dysfunction JACC. 1991; 18:564-72.
Cummins RO, Ornato JP, Thies WH, Pepe PE, Billi JE, Seidel J, Jaffe AS, Flint LS, Goldstein S, Abramson NS, Brown C, Chandra NC, Gonzalez ER, Newell L, Stults KR, Membrino GE. Improving survival from sudden cardiac arrest: The "Chain of Survival" Concept. Circulation. 1991; 83:1832-47.
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Goldstein JA, Barzilai B, Rosamond TL, Eisenberg PR, Jaffe AS. Determinants of hemodynamic compromise with severe right ventricular infarction Circulation.1990;82:(2):359-368.
Vered I, Vered Z, Perez JE, Jaffe AS, Whyte MP. Normal left ventricular function in children with x-linked hypophosphatemic rickets. A Doppler echocardiography study J Bone Min Res. 1990; 5:469-74.
Carney RM, Freeland KE, Ludbrook PA, Saunders RD, Jaffe AS. Major depression, panic disorder, and mitral valve prolapse in patients who complainof chest pain Am J Med. 1990; 89:757-60.
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Eisenberg PR, Jaffe AS, Stump DC, Collen DJ, Bovill EG. Validity of enzyme-linked immunoabsorbent assays of cross-linked fibrin degradation products as a measure of clot lysis Circulation. 1990; 82:1159-68.
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Barzilai B, Davis VG, Stone PH, Jaffe AS, MILIS Study Group. Prognostic significance fo mitral regurgitation in acute myocardial infarction AM J Cardiol. 1990; 65:1169-75.
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Scharp DW, Lacy PE, Santiago JV, McCullough CS, Weide LG, Falqui L, Marchetti P, Gingerish RL, Jaffe AS, Cryer PE, Anderson CB, Flye MW. Insulin independence after Islet transplantation into Type I diabetic patient Diabetes. 1990; 39:515-18.
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Eisenberg PR, Lucore C, Kaufman L, Sobel BE, Jaffe AS, Rich S. Elevations of levels of fibrinopeptid A indicative of pulmonary vascular thrombosis in patient with primary pulmonary hypertension Circulation. 1990; 82:841-7.
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Carney RM, Freedland KE, Jaffe AS. Insomnia and Depression Prior to Myocardial Infarction Psychosomatic Medicine. 1990; 52:603-9.
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Winters KJ, Eisenberg PR, Jaffe AS, Santoro SA. Dependence of plasmin-mediated degradation of platelet adhesive receptors on temperature and CA++ concentration Blood. 1990; 76:1546-57.
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Cohen ML, Barzilai B, Gutierrez F, Jaffe AS, Eisenberg P. Treatment of prosthetic tricuspid valve thrombosis with low-dose tissue plasminogen activator. Am Heart J. 1990; 120:978-9.
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Jaffe AS. Automated defibrillation: A problem, a challenge and an opportunity - The role of Internists and cardiologists in the prehospital care of their patients Cont Intern Med 8-1. 1990; 0:8-10.
Cummins RO, Thies W, Paraskos J, Kerber RE, Billi JE, Seidel J, Jaffe AS, Flint L, Ornato JP, Abramson NS, Brown C, Chandra NC, Gonzales ER, Newell L, Stults KR, Membrino GE, Pepe PE. Encouraging early defibrillation: The American Heart Association and automated external defibrillation. Ann Emerg Med. 1990; 19:1245-8.
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Carney RM, Freedland KE, Sapira JD, Jaffe AS. Panic disorder and depression in patients with chest pain not due to coronary artery disease. Am J Cardiol (letter). 1990; 15: 1048.
Devries S, Jaffe AS, Geltman EM, Sobel BE, Abendschein D. Enzymatic estimation of the extent of irreversible myocardial injury early after reperfusion. Am Heart J. 1989; 117:31-6.
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Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB, Turi ZG, Strauss WH, Willerson JT, Sobel BE, Robertson T, Passamani E, Braunwald E, Jaffe AS, MILIS Study Group. The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: Contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis J Am Coll Cardiol. 1989; 14:49-57.
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Vered I, Vered Z, Perez JE, Jaffe AS, Whyte MP. Normal left ventricular performance documented by Doppler echocardiography in patients with longstanding hypocalcemia AM J Med. 1989; 86:413-6.
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Eisenberg PR, Shaw D, Schaab C, Jaffe AS. Concordance of creatine kinase-MB activity and mass Clin Chem. 1989; 35:440-3.
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Scharp D, Lacy P, Ricordi C, Boyle P, Santiago J, Cryer P, Gingerick R, Jaffe AS, Anderson C, Flye W. Human islet transplantation in patient with type-1 diabetes Transplant Proc. 1989; 21:2744-5.
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Carney RM, Freedland K, Rich MW, Jaffe AS. Stimulus induced analgesia and silent myocardial ischemia. J Appl Cardiol. 1989; 4:271-4.
Jaffe AS, TIMI Study Group. Comparison of invaasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction - Results of the thrombolysis in myocardial infarction (TIMI) phase II trial N Engl J Med. 1989; 320:618-27.
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Hammerman M, Sagel S, Jaffe AS, Becich M. Atrial fibrillation, refractory hypotension, and death in a 70-year-old woman Am J Med.1988;85:(2)227-234.
Hammerman M, Jaffe AS. Clinical Pathologic Conference: Acute adrenal insufficiency.Atrial Fibrillation, Refractory Hypotension, and Death in a 70-year-old woman Am J Med. 1988; 85(2):227-34.
Stone PH, Raabe DS, Jaffe AS, Gustafson N, Muller JE, Turi ZG, Rutherford JD, Poole WK, Passamani E, Willerson JT, et al. Prognostic significance of location and type of myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll Cardiol. 1988 Mar; 11(3):453-63.
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Barzilai B, Gessler C, Perez JE, Schaab C, Jaffe AS. Significance of Doppler detected mitral regurgitation acute myocardial infarction. Am J Cardiol. 1987; 61(4):220-3.
Eisen HJ, Barzilai B, Jaffe AS, Geltman EM. Relationship of QRS scoring system to enzymatic and pathologic infarct size: The role of infarct location. Am Heart J. 1988; 115:993-1001.
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Muller JE, Rude RE, Baunwald E, Hartwell TD, Roberts R, Sobel BE, Ritter C, Parker CB, Jaffe AS, Stone PH, Raabe DS, Willerson JT, Robertson T, MILIS Study Group. Myocardial infarct extension: Incidence, outcome, and risk factors in the MILIS study. Ann Intern Med. 1988; 108:1-6.
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Roberts R, Braunwald E, Muller JE, Croft C, Gold HK, Hartwell TD, Jaffe AS, Mullin SM, Parker C, Passamani ER, Poole K, Robertson T, Raabe DS, Rude RE, Stone PH, Turi ZG, Sobel BE, Willerson JT, MILIS Study Group. The effect of hyaluronidase on mortality and morbidity in patients with early peaking of plasma MB CK and nontransmural ischemia: Retrospective analysis of MILIS data. Br Heart J. 1988; 60:290-8.
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Eisenberg PR, Miletich JP, Sobel BE, Jaffe AS. Differential effects of activation of prothrombin by streptokinase compared with urokinase and tissue-type plasminogen activator (t-PA). Thrombosis Res. 1988; 50:707-17.
Rao AK, Pratt C, Berke A, Jaffe AS, Ockene I, Schreiber TL, Bell Knatterud G, Robertson TL, Terrin ML, for the TIMI Investigators. The thrombolysis in myocardial infarction trial - Phase I. Hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase J Am Col Cardiol. 1988; 11:1-11.
Seacord LM, Abendschein DR, Nohara R, Hartzler G, Sobel BE, Jaffe AS. Detection of reperfusion within one hour after coronary recanalization by analysis of isoforms of the MM creatine kinase isoenzyme in plasma Fibrinolysis. 1988; 2:151-6.
Nohara R, Sobel BE, Jaffe AS, Abendschein DR. Quantitative analysis of isoforms of creatine kinase MM in plasma by chromatofocusing with on-line monitoring of enzyme activity Clin Chem 2. 1988; 34: 235-9.
Lee RT, Lee TH, Poole WK, Gustafson N, Stone PH, Jaffe AS, Muller JE, Sobel BE, Braunwald E, MILIS Study Group. Rate of disappearance of creatine kinase and creatine kinase-MB after acute myocardial infarction. Clinical determinants of variability Am Heart J. 1988; 116:661-4.
Abendschein D, Seacord LM, Nohara R, Sobel BS, Jaffe AS. Prompt detection of myocardial injury by assay of creatine kinase isoforms in initial plasma samples Clin Cardiol. 1988; 11:661-4.
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Jaffe AS, Safdar S, Barzilai B, Semenkovich J, Saffitz J. Clinical Pathologic Conference: Carcinoma of the cervix with metastasis to the heart. Am J Med. 1988; 84:463-74.
Jaffe AS, TIMI Study Group. Immediate versus delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction - TIMI IIA results. J Am Med Assoc. 1988; 260:2849-58.
Eisenberg PR, Sobel BE, Jaffe AS. Characterization In Vivo of the fibrin specificity of activators of the fibrinolytic system. Circulation. 1988; 78:592-7.
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Kennedy JW, Atkins JM, Goldstein S, Jaffe AS, McIntyre KM, Mueller HS, Paraskos JA, Weaver WD. Recent changes in management of acute myocardial infarction: Implications for Emergency Care Physicians. J Am Coll Cardiol. 1988; 11:446-9.
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Eisenberg PR, Sherman LA, Perez J, Jaffe AS. Relationship between elevated plasma levels of crosslinked fibrin degradation products (XL-FDP) and the clinical presentation of patients with myocardial infarction. Thromb Res. 1987; 46:109-20.
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Gessler CJ, Jaffe AS. Hemodynamic monitoring and pacing with one catheter: A pilot study. Cath and Cardiovasc Diag. 1987; 13:141-4.
Eisenberg PR, Sherman LA, Tiefenbrunn AJ, Ludbrook PA, Sobel BS, Jaffe AS. Sustained fibrinolysis after administration of t-PA despite ist short half life in the circulation. Thromb and Hemostasis. 1987; 57:35-40.
Tofler GH, Stone PH, Muller JE, Willich SN, Davis VKL, Poole WK, Strauss W, Willerson JT, Sobel BE, Jaffe AS, Robertson T, Passamani E, Braunwald E, MILIS Study Group. Effects of gender and race on prognosis after myocardial infarction: Adverse prognosis for women particularly black women. J Am Coll Cardiol. 1987; 9:473-82.
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Cox DA, Stone PH, Muller JE, Parker C, Hartwell TD, Rutherford JD, Roberts R, Jaffe AS, Hackel DB, Passamani E, Robertson T, Sobel BE, Willerson JT, Braunwald E, MILIS Study Group. Prognostic implications of an early peak in plasma MB creatine kinase patients with acute myocardial infarction. J Am Coll Cardiol. 1987; 10:979-90.
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Eisenberg PR, Sherman LA, Jaffe AS. Paradoxical elevation of fibrinopeptide A after streptokinase: Evidence for continued thrombosis despite intense fibrinolysis. JACC. 1987; 10:527-9.
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Jaffe AS, Biello DR, Sobel BE, Geltman EM. Enhancement of metabolism of jeopardized myocardium by nifedipine. Intern J Cardiol. 1987; 15:77-89.
Abendschein DR, Serota H, Plummer TH Jr, Amiraian K, Strauss AW, Sobel BE, Jaffe AS. Conversion of MM creatine kinase isoforms in human plasma by carboxypeptidase. N J Lab Clin Med. 1987; 110:798-806.
Carney RM, Rich M, teVelde A, Saini J, Clark K, Jaffe AS. Major depression disorder: A common psychiatric disorder in patients with coronary artery disease. Am J Cardiol. 1987; 60:1273-5.
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Lamas GA, Muller JE, Turi ZG, Stone PH, Rutherford JD, Jaffe AS, Raabe DS, Rude RE, Mark DB, Califf RM, Gold HK, Robertson T, Passamani ER, Braunwald E, MILIS Study Group. A simplified method to predict the occurence of complete heart block during acute myocardial infarction Am J Cardiol. 1986; 57(15):1213-9.
Jaffe AS, Sobel BE. Thrombolysis with tissue-type plasminogen activator in acute myocardial infarction. Potentials and pitfalls. JAMA. 1986 Jan 10; 255(2):237-9.
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Muller JE, Turi ZG, Stone PH, Rude RE, Raabe DS, Jaffe AS, Gold HK, Gustafson N, Poole WK, Passamani E, Smith TW, Braunwald E, MILIS Study Group. Digoxin therapy and mortality following myocardial infarction: Experience in the MILIS study. N Eng J Med. 1986; 314:265-71.
Croft HC, Rude RE, Gustafson N, Stone PH, Poole WK, Roberts R, Strauss HW, Raabe DS, Thomas LJ, Jaffe AS, Muller J, Hoagland P, Sobel BE, Passamani ER, Braunwald E, Willerson JT, MILIS Study Group. Abrupt beta-blockade withdrawal in patients with acute myocardial infarction. Effects on infarct size, left ventricular function, and hospital course. Circulation. 1986; 73:1281-90.
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Wheelan K, Mukharji J, Rude RE, Poole WK, Gustafson N, Thomas LJ, Strauss HW, Jaffe AS, Muller JE, Roberts R, Croft CH, Passamani E, Willerson JT, MILIS Study Group. Sudden death and its relationship to QT interval prolongation following acute myocardial infarction (2-year follow-up). Am J Cardiol. 1986; 57:745-50.
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Stone PH, Turi ZG, Muller JE, Parker C, Hartwell T, Rutherford JD, Jaffe AS, Raabe DS, Passamani ER, Willerson JT, Sobel BE, Robertson TL, Braunwald E, MILIS Study Group. Prognostic significance of the exercise treadmill test performance six months after myocardial infarction. J Am Coll Cardiol. 1986; 8:1007-17.
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Jaffe AS, Serota H, Grace A, Sobel BE. Diagnostic changes in plasma creatine kinase isoforms early after the onset of acute myocardial infarction. Circulation. 1986; 74:105-9.
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Spadaro JJ, Ludbrook PA, Tiefenbrunn AJ, Kurnik PB, Jaffe AS. Paucity of subtle myocardial injury after angioplasty delineated with MB CK. Cath and Cardiovasc Dis. 1986; 12:230-4.
Pierce GF, Eds, Chan KM, Ladenson JH, Discussant, Jaffe AS. Increased creatine kinase MB isoenzyme in the absence of acute myocardial infarction. Clin Chemistry group. 1986; 32:2044-51.
Jaffe AS, MILIS Study Group. Hyaluronidase therapy for acute myocardial infarction: Results of a randomized, blinded, multicenter trial. Am J Cardiol. 1986; 57:1236-43.
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Jaffe AS, Montgomery WH, Donegan J, McIntyre KM et al. 1985 National Conference on Standards and Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care. JAMA.1986;255:(21):2902-2989.
Turi ZG, Stone PH, Muller JE, Parker C, Rude RE, Raabe DE, Jaffe AS, Hartwell TD, Robertson TL, Braunwald E, MILIS Study Group:. Implications for acute intervention of time of hospital arrival of patients with acute mycocardial infarction. Am J Cardiol. 1986; 58:203-9.
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Eisenberg PR, Sherman L, Rich M, Schwartz D, Schechtman K, Geltman EM, Sobel BE, Jaffe AS. Importance of continued activation of thrombin reflected by fibrinopeptides A to the efficacy of thrombolysis. JACC. 1986; 7:1255-62.
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Genton R, Jaffe AS. Management of congestive heart failure in patients with acute myocardial infarction. JAMA. 1986; 256:2556-60.
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Jaffe AS. The state of the art of myocardial infarction. Circulation. 1986; 74: IV-120.
Jaffe AS. Cardiovascular Pharmacology I. Circulation. 1986; Suppl): 0.
Turi ZG, Rutherford JD, Roberts R, Muller JE, Jaffe AS, Rude RE, Parker C, Raabe DS, Stone PH, Hartwell TD. Electrocardiographic, enzymatic and scintigraphic criteria of acute myocardial infarction as determined from study of 726 patients (A MILIS Study). Am J Cardiol. 1985 Jun 1; 55 (13 Pt 1):1463-8
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Eisenberg PR, Lee RG, Biello DR, Geltman EM, Jaffe AS. Chest pain after nontransmural infarction: The absence of remediable coronary vasospasm. Am Heart J. 1985; 11:515-31.
Semenkovich CF, Jaffe AS. Adverse effects due to morphine sulfate: A challenge to previous clinical doctrine Am J Med. 1985; 79:325-30.
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Jansen DE, Corbett JR, Lewis SE, Wolfe CL, Gabliani G, Filipchuk N, Redish G, Parkey RW, Buja M, Jaffe AS, Sobel BS, Willerson JT. Measurement of myocardial infarct size: A comparison of single photon emission computed tomography with pyrophosphate and serial CK-MB measurements Circulation. 1985; 72:237-333.
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Eisenberg PE, Sherman LA, Schechtman K, Sobel BE, Jaffe AS. Fibrinopeptide A: A marker of acute coronary thrombosis Circulation. 1985; 71:912-8.
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Jaffe AS, TIMI Study Group. The thrombolysis in myocardial infarction (TIMI) trial - Phase I findings N Engl J Med. 1985; 312:932-6.
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Jaffe AS, Garfinkel BT, Ritter CS, Sobel BE. Plasma, MB creatine kinase after vigorous exercise in professional athletes Am J Cardiol. 1984; 53:856-8.
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Mukharji J, Rude RE, Poole KW, Thomas LJ, Strauss HW, Jaffe AS, Muller JE, Roberts R, Raabe DS, Croft CH, Passamani E, Braunwald E, Willerson JT, the MI. Late sudden death following acute myocardial infarction: Multivariate analysis of risk factors Am J Cardiol. 1984; 54:31-6.
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Jaffe AS, Ritter C, Meltzer V, Harter H, Roberts R. Unmasking artifactural increases in creatine kinase isoenzymes in patients with renal failure J Lab Clin Med. 1984; 104:193-202.
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Eisenberg PR, Jaffe AS, Schuster DP. Clinical evaluation compared to pulmonary artery catheterization in the hemodynamic assessment of critically-ill patients Crit Care Med. 1984; 12:549-52.
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Roberts R, Croft C, Gold HK, Tyler DH, Jaffe AS, Muller JE, Mullin SM, Parker C, Passamani ER, Poole WK, Raabe DS, Rude RE, Stone PH, Turi G, Sobel BE, Willerson JT, Braunwald E, MILIS Study Group. Effect of propranolol on myocardial infarct size in a randomized, blinded, multicenter trial N Engl J Med. 1984; 311:218-25.
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Sobel BE, Geltman EM, Tiefenbrunn AJ, Jaffe AS, Spadaro JJ, Ter-Pogossian MM, Collen D, Ludbrook PA. Improved regional myocardial metabolism after coronary thrombolysis iwth tissue-type plasminogen activator (t-PA) or streptokinase Circulation. 1984; 69:983-9.
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Jaffe AS, Lee R, Perez J, Geltman EM, Wilner G, Sobel BE. Lack of elevation of platelet factor IV in plasma from patient with myocardial infarction J Am Coll Cardiol. 1984; 4:653-9.
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Rosenblum AM, Ludbrook PA, Jaffe AS. Significance of elevated MB creatine kinase in patients after cardiac catheterization. Cardiac Catheter Diagn. 1984; 10:547-52.
Sedlis S, Saffitz J, Schwob V, Jaffe AS. Cardiac amyloidosis simulating hypertrophic myopathy. Am J Cardiol. 1984; 53:969-70.
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Hackel DB, Reimer KA, Ideker RE, Mikat EM, Hartwell TD, Parker CB, Braunwald EB, Gold HK, Jaffe AS, Raabe DS, Rude RE, Sobel BE, Stone PH, Buja M, Muller JE, Roberts R, MILIS Study Group:. Comparison of enzymatic, anatomic estimates of myocardial infarct in man. Circulation. 1984; 70:824-35.
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Shafer KE, Santoro SA, Sobel BE, Jaffe AS. Monitoring activity of fibrinolytic therapy: A therapeutic challenge. Am J Med. 1984; 75:879-86.
Jaffe AS, Spadaro JJ, Schechtman K, Robert R, Geltman EM, Sobel BE. Increased congestive heart failure after infarction of modest extent in patients with diabetes mellitus. Am Heart J. 1984; 108:31-7.
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Jaffe AS, Geltman EM, Tiefenbrunn AJ, Ambos HD, Strauss H, Sobel BE, Roberts R. Reduction in infarct size in patient with inferior infarction with intravenous nitroglycerin. A randomized prospective study. Br Heart J. 1983; 49:452-69.
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Billadello JJ, Smith JL, Ludbrook PA, Tiefenbrunn AJ, Jaffe AS, Sobel BE, Geltman EM. The implications of "Reciprocal" ST segment depression associated with acute myocardial infarction identified by positron tomography J Am Coll Cardiol. 1983; 2:616-24.
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Stone PH, Muller JE, Turi ZG, Geltman E, Jaffe AS, Braunwald E. Efficacy of nifedipine therapy in patients with refractory angina pectoris: Significance of the presence of coronary vasospasm Am Heart J. 1983; 106:644-52.
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Klahr S, Jaffe AS, McKeel T. Cyanotic Feet and Renal Failure in a 67-year-old man Am J Med. 1983; 75:509-17.
Stone PH, Muller JE, Turi ZG, Geltman E, Jaffe AS, Braunwald E:. Efficacy of nifedipine therapy in patients with refractory angina pectroris: Significance of the presence of coronary vasospasm. Arq Bras Cardiol. 1983; 41:469-76.
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Gutierrez FR, McKnight RC, Jaffe AS, Ludbrook PA, Biello D, Weldon CS. Double porcine valve replacement in carcinoid heart disease: A case report. Chest. 1982; 181:101.
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Jaffe AS, Robert R. Use of intravenous nitroglycerin in cardiovascular disease. Pharmacotherapy. 1982; 2(5):273-8.
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Clark KW, Geltman EM, Miller JP, Moore P, Madden KA, Thomas JJ, Hartwell TD, Jaffe AS, Rabbe DS, Stone PH, Gold HK, Rude RE, the MILIS Study Group:. Reproducibility of dysrhythmia findings by a centralized laboratory within a major multicenter trial. 1982 Proceeding of Computers in Cardiology, Seattle, Washington.. 1982; 0: 0.
Jaffe AS, Geltman EM, Rodey GE, Uitto J. Mitral valve prolapse:A consistent manifestation of type IV Ehlers-Danlos Syndrome (the pathogenic role of abnormal type III collagen synthesis). Circulation. 1981; 64:121.
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Kornfeld S, Hruska K, Berger N, Jaffe AS, Shields H, DeSchriver K. Gastric outlet obstruction in patients with multiple myeloma. Am J Med. 1980; 68:141-48.
Ahumada GG, Karlsberg RP, Jaffe AS, Ambos HD, Sobel BE, Roberts R. Reduction of early ventricular arrhythmias by acebutolol in patients with acute myocardial infarction Br Heart J. 1979; 41:654.
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Jaffe AS, Klein MS, Patel BR, Siegel BA, Roberts R. Abnormal technetium-99m pyrophosphate images in unstable angina: Ischemia versus infarction? Am J Cardiol. 1979; 44:1035.
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Srebro R, Jaffe AS. The origin of dark noise in foveal vision. J Optical Soc Am. 1968; 58:1313.

Allan S. Jaffe, M.D.

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