Publications

1. Cha YM, Lee HC, Mulpuru SK, Deshmukh AJ, Friedman PA, Asirvatham SJ, Bradley DJ, Madhavan M, Abou Ezzeddine OF, Wen S, Liddell BW, Curran C, Li C, Dasari S, Lanza IR, Bailey KR, Chen HH. Cardiac Resynchronization Therapy for Patients With Mild to Moderately Reduced Ejection Fraction and Left Bundle Branch Block. Heart Rhythm. 2024 May 19 [Epub ahead of print]
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2. Ma X, McKie PM, Iyer SR, Scott C, Bailey K, Johnson BK, Benike SL, Chen H, Miller WL, Cabassi A, Burnett JC Jr, Cannone V. MANP in Hypertension With Metabolic Syndrome: Proof-of-Concept Study of Natriuretic Peptide-Based Therapy for Cardiometabolic Disease. JACC Basic Transl Sci. 2024 Jan; 9 (1):18-29 Epub 2023 Nov 01
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3. Vinnakota S, Adel FW, McKie PM, Scott CG, Chen HH. The Cardiorenal Effects of Chronic Phosphodiesterase-V Inhibition in Preclinical Diastolic Dysfunction (Stage B Heart Failure). J Card Fail. 2023 Oct; 29 (10):1461-1465 Epub 2023 June 07
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4. Severson S, Fink A, McCoy R, Liedl C, Bieber P, Juntunen M, Chen H, Lin G. Community Paramedic Home Care Program for Acute Decompensated Heart Failure: A Pilot Study. Circ Cardiovasc Qual Outcomes. 2023 Sep; 16 (9):e009142 Epub 2023 July 20
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5. Ma X, Iyer SR, Ma X, Reginauld SH, Chen Y, Pan S, Zheng Y, Moroni DG, Yu Y, Zhang L, Cannone V, Chen HH, Ferrario CM, Sangaralingham SJ, Burnett JC Jr. Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation. Int J Mol Sci. 2023 May 10; 24 (10)
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6. Sangaralingham SJ, Kuhn M, Cannone V, Chen HH, Burnett JC. Natriuretic peptide pathways in heart failure: further therapeutic possibilities. Cardiovasc Res. 2023 Feb 3; 118 (18):3416-3433
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7. Martens P, Chen HH, Verbrugge FH, Testani JT, Mullens W, Tang WHW. Assessing intrinsic renal sodium avidity in acute heart failure: implications in predicting and guiding decongestion. Eur J Heart Fail. 2022 Oct; 24 (10):1978-1987 Epub 2022 Sept 06
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8. Young KA, Scott CG, Rodeheffer RJ, Chen HH. Incidence of Preclinical Heart Failure in a Community Population. J Am Heart Assoc. 2022 Aug 02; 11(15):e025519. Epub 2022 Jul 20.
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9. Dzhoyashvili NA, Iyer SR, Chen HH, Burnett JC Jr. MANP (M-Atrial Natriuretic Peptide) Reduces Blood Pressure and Furosemide-Induced Increase in Aldosterone in Hypertension. Hypertension. 2022 Apr; 79 (4):750-760 Epub 2022 Jan 20
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10. Wan SH, Slusser JP, Hodge DO, Chen HH. Outcomes of Patients With Diabetes Versus Patients Without Diabetes Hospitalized With Acute Heart Failure. Am J Cardiol. 2022 Feb 15; 165:65-71 Epub 2021 Dec 18
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11. Hubers SA, Wan SH, Adel FW, Benike SL, Burnett JC Jr, Scott C, Chen HH. Cardiorenal Effects of Long-Term Phosphodiesterase V Inhibition in Pre-Heart Failure. J Am Heart Assoc. 2022 Jan 18; 11 (2):e022126 Epub 2022 Jan 08
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12. Adel FW, Zheng Y, Wan SH, Greason C, Pan S, Ameenuddin S, Chen HH. Insulin Therapy is Associated With Increased Myocardial Interstitial Fibrosis and Cardiomyocyte Apoptosis in a Rodent Model of Experimental Diabetes. Front Physiol. 2022; 13:890907 Epub 2022 Apr 27
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13. Chen HH, Wan SH, Iyer SR, Cannone V, Sangaralingham SJ, Nuetel J, Burnett JC Jr. First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension. Hypertension. 2021 Dec; 78 (6):1859-1867 Epub 2021 Oct 18
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14. Ma X, Chen Y, Reginauld SH, Scott CG, Iyer SR, Schaefer JJ, Ichiki T, Chen HH, Rule AD, Burnett JC Jr, Sangaralingham SJ. Prognostic Value of Urinary and Plasma C-Type Natriuretic Peptide in Acute Decompensated Heart Failure. JACC Heart Fail. 2021 Sep; 9 (9):613-623 Epub 2021 July 07
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15. Wan SH, McKie PM, Slusser JP, Burnett JC Jr, Hodge DO, Chen HH. Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction. Physiol Rep. 2021 Aug; 9 (16):e14974
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16. Young KA, Scott CG, Rodeheffer RJ, Chen HH. Progression of Preclinical Heart Failure: A Description of Stage A and B Heart Failure in a Community Population. Circ Cardiovasc Qual Outcomes. 2021 May; 14 (5):e007216 Epub 2021 May 06
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17. Hubers SA, Schirger JA, Sangaralingham SJ, Chen Y, Burnett JC Jr, Hodge D, Chen HH. B-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial. Heart. 2021 Mar; 107 (5):396-402 Epub 2020 Aug 03
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18. Fudim M, Ashur N, Jones AD, Ambrosy AP, Bart BA, Butler J, Chen HH, Greene SJ, Reddy Y, Redfield MM, Sharma A, Hernandez AF, Felker GM, Borlaug BA, Mentz RJ. Implications of peripheral oedema in heart failure with preserved ejection fraction: a heart failure network analysis. ESC Heart Fail. 2021 Feb; 8 (1):662-669 Epub 2020 Dec 09
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19. Adel FW, Rikhi A, Wan SH, Iyer SR, Chakraborty H, McNulty S, Tang WHW, Felker GM, Givertz MM, Chen HH. Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure. J Card Fail. 2020 Aug; 26 (8):727-732 Epub 2020 May 27
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20. Vinnakota S, Chen HH. The Importance of Natriuretic Peptides in Cardiometabolic Diseases. J Endocr Soc. 2020 Jun 1; 4 (6):bvaa052 Epub 2020 May 15
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21. Adel FW, Esmaeilzadeh S, Chen HH. 32-Year-Old Man With Dyspnea on Exertion and Dizziness. Mayo Clin Proc. 2020 Apr; 95 (4):e37-e42 Epub 2020 Feb 27
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22. Chen Y, Schaefer JJ, Iyer SR, Harders GE, Pan S, Sangaralingham SJ, Chen HH, Redfield MM, Burnett JC Jr. Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP. Am J Physiol Regul Integr Comp Physiol. 2020 Apr 1; 318 (4):R669-R676 Epub 2020 Feb 05
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23. Klajda MD, Scott CG, Rodeheffer RJ, Chen HH. Diabetes Mellitus Is an Independent Predictor for the Development of Heart Failure: A Population Study. Mayo Clin Proc. 2020 Jan; 95 (1):124-133
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24. Wan SH, Torres-Courchoud I, McKie PM, Slusser JP, Redfield MM, Burnett JC Jr, Hodge DO, Chen HH. Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP. JACC Basic Transl Sci. 2019 Dec; 4 (8):962-972 Epub 2019 Dec 23
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25. Vinnakota S, Scott CG, Rodeheffer RJ, Chen HH. Estimated Glomerular Filtration Rate, Activation of Cardiac Biomarkers and Long-Term Cardiovascular Outcomes: A Population-Based Cohort. Mayo Clin Proc. 2019 Nov; 94 (11):2189-2198 Epub 2019 Oct 23
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26. Wan SH, Pumerantz AS, Dong F, Ochoa C, Chen HH. Comparing the influence of 2009 versus 2016 ASE/EACVI diastolic function guidelines on the prevalence and echocardiographic characteristics of preclinical diastolic dysfunction (stage B heart failure) in a Hispanic population with type 2 diabetes mellitus. J Diabetes Complications. 2019 Aug; 33 (8):579-584 Epub 2019 May 07
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27. Chen Y, Zheng Y, Iyer SR, Harders GE, Pan S, Chen HH, Ichiki T, Burnett JC Jr, Sangaralingham SJ. C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts. J Mol Cell Cardiol. 2019 May; 130:140-150 Epub 2019 Apr 04
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28. Yang M, Li X, Yang D, Li Y, Zhou S, Liang J, Wu G, Del-Carpio Munoz F, Chen HH, Friedman PA, Cha YM. Cardiac resynchronization therapy improves myocardial conduction. Pacing Clin Electrophysiol. 2019 Feb; 42 (2):238-246 Epub 2018 Dec 27
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29. Berent TE, Dorschner JM, Meyer T, Craig TA, Wang X, Kunz H, Jatoi A, Lanza IR, Chen H, Kumar R. Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice. PLoS One. 2019; 14 (12):e0226440 Epub 2019 Dec 18
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30. Borlaug BA, Anstrom KJ, Lewis GD, Shah SJ, Levine JA, Koepp GA, Givertz MM, Felker GM, LeWinter MM, Mann DL, Margulies KB, Smith AL, Tang WHW, Whellan DJ, Chen HH, Davila-Roman VG, McNulty S, Desvigne-Nickens P, Hernandez AF, Braunwald E, Redfield MM, National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. JAMA. 2018 Nov 6; 320 (17):1764-1773
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31. Kawakami R, Lee CYW, Scott C, Bailey KR, Schirger JA, Chen HH, Benike SL, Cannone V, Martin FL, Sangaralingham SJ, Ichiki T, Burnett JC Jr. A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure. Clin Pharmacol Ther. 2018 Sep; 104 (3):546-552 Epub 2018 Jan 11
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32. Wan SH, Slusser JP, Hodge DO, Chen HH. The Vascular-Renal Connection in Patients Hospitalized With Hypertensive Crisis: A Population-Based Study. Mayo Clin Proc Innov Qual Outcomes. 2018 Jun; 2 (2):148-154 Epub 2018 Mar 15
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33. Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM. Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. Circulation. 2018 May 8; 137 (19):2016-2028 Epub 2018 Jan 19
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34. Jain A, Scott C, Chen HH. The renal-cardiac connection in subjects with preserved ejection fraction: a population based study. ESC Heart Fail. 2017 Aug; 4 (3):266-273 Epub 2017 May 16
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35. Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever TD, Classic KL, Pham L, Chen HH, Burnett JC, Russell SJ, Redfield MM. Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2017 Aug 1; 313 (2):H392-H407 Epub 2017 May 26
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36. Grodin JL, Gallup D, Anstrom KJ, Felker GM, Chen HH, Tang WHW. Implications of Alternative Hepatorenal Prognostic Scoring Systems in Acute Heart Failure (from DOSE-AHF and ROSE-AHF). Am J Cardiol. 2017 Jun 15; 119 (12):2003-2009 Epub 2017 Mar 29
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37. AbouEzzeddine OF, McKie PM, Dunlay SM, Stevens SR, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2017 Feb 18; 6 (2)
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38. Grodin JL, Sun JL, Anstrom KJ, Chen HH, Starling RC, Testani JM, Tang WH. Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF). Am J Cardiol. 2017 Jan 1; 119 (1):78-83 Epub 2016 Sept 30
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39. AbouEzzeddine OF, McKie PM, Scott CG, Rodeheffer RJ, Chen HH, Michael Felker G, Jaffe AS, Burnett JC, Redfield MM. Biomarker-based risk prediction in the community. Eur J Heart Fail. 2016 Nov; 18 (11):1342-1350
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40. Gandhi PU, Gaggin HK, Redfield MM, Chen HH, Stevens SR, Anstrom KJ, Semigran MJ, Liu P, Januzzi JL Jr. Insulin-Like Growth Factor-Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial. JACC Heart Fail. 2016 Nov; 4 (11):860-869 Epub 2016 Oct 12
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41. Torres-Courchoud I, Chen HH. B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics. Rev Clin Esp (Barc). 2016 Oct; 216 (7):393-398 Epub 2016 Mar 05
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42. Wan SH, Stevens SR, Borlaug BA, Anstrom KJ, Deswal A, Felker GM, Givertz MM, Bart BA, Tang WHW, Redfield MM, Chen HH. Differential response to low-dose dopamine or low-dose nesiritide in acute heart failure with reduced or preserved ejection fraction results from the rose ahf trial (renal optimization strategies evaluation in acute heart failure) Circulation-Heart Failure. 2016 Aug; 9: (8)e002593.
    
43. Wan SH, Stevens SR, Borlaug BA, Anstrom KJ, Deswal A, Felker GM, Givertz MM, Bart BA, Tang WH, Redfield MM, Chen HH. Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure). Circ Heart Fail. 2016 Aug; 9 (8)
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44. Kelly JP, Cooper LB, Gallup D, Anstrom KJ, Chen HH, Redfield MM, O'Connor CM, Mentz RJ, Hernanadez AF, Felker GM. Implications of Using Different Definitions on Outcomes in Worsening Heart Failure. Circ Heart Fail. 2016 Aug; 9 (8)
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45. Wan SH, McKie PM, Schirger JA, Slusser JP, Hodge DO, Redfield MM, Burnett JC Jr, Chen HH. Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure). JACC Heart Fail. 2016 Jul; 4 (7):539-547 Epub 2016 Feb 10
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46. Patel PA, Scott CG, Rodeheffer RJ, Chen HH. The Natural History of Patients With Isolated Metabolic Syndrome. Mayo Clin Proc. 2016 May; 91 (5):623-33 Epub 2016 Apr 08
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47. McKie PM, Schirger JA, Benike SL, Harstad LK, Slusser JP, Hodge DO, Redfield MM, Burnett JC Jr, Chen HH. Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure. Eur J Heart Fail. 2016 Apr; 18 (4):433-41 Epub 2016 Jan 24
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48. AbouEzzeddine OF, Lala A, Khazanie PP, Shah R, Ho JE, Chen HH, Pang PS, McNulty SE, Anstrom KJ, Hernandez AF, Redfield MM, NHLBI Heart Failure Clinical Research Network. Evaluation of a provocative dyspnea severity score in acute heart failure. Am Heart J. 2016 Feb; 172:34-41 Epub 2015 Oct 20
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49. Huang Y, Ng XW, Lim SG, Chen HH, Burnett JC Jr, Boey YC, Venkatraman SS. In vivo Evaluation of Cenderitide-Eluting Stent (CES) II. Ann Biomed Eng. 2016 Feb; 44 (2):432-41 Epub 2015 July 16
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50. Grodin JL, Stevens SR, de Las Fuentes L, Kiernan M, Birati EY, Gupta D, Bart BA, Felker GM, Chen HH, Butler J, Davila-Roman VG, Margulies KB, Hernandez AF, Anstrom KJ, Tang WH. Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure. J Card Fail. 2016 Jan; 22 (1):26-32 Epub 2015 July 21
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51. Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E, NHLBI Heart Failure Clinical Research Network. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10; 373 (24):2314-24 Epub 2015 Nov 08
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52. Sangaralingham SJ, McKie PM, Ichiki T, Scott CG, Heublein DM, Chen HH, Bailey KR, Redfield MM, Rodeheffer RJ, Burnett JC Jr. Circulating C-type natriuretic peptide and its relationship to cardiovascular disease in the general population. Hypertension. 2015 Jun; 65 (6):1187-94 Epub 2015 Apr 20
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53. Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8 (3):533-41 Epub 2015 Mar 17
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54. Patel P, Chen HH. Natriuretic Peptides as a Novel Target in Resistant Hypertension. Curr Hypertens Rep. 2015 Mar; 17 (3):18
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55. AbouEzzeddine OF, Haines P, Stevens S, Nativi-Nicolau J, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail. 2015 Mar; 3 (3):245-52
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56. Wan SH, Chen HH. Targeting preclinical diastolic dysfunction to prevent heart failure: contemporary insights. Current Cardiovascular Risk Reports. 2015; 9(8):40.
    
57. Ng XW, Huang Y, Liu KL, Lim SG, Chen HH, Burnett JC Jr, Freddy Boey YC, Venkatraman SS. In vitro evaluation of cenderitide-eluting stent I -an antirestenosis and proendothelization approach. J Pharm Sci. 2014 Nov; 103 (11):3631-3640 Epub 2014 Sept 15
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58. Torres-Courchoud I, Chen HH. Is there still a role for low-dose dopamine use in acute heart failure? Curr Opin Crit Care. 2014 Oct; 20(5):467-71.
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59. Jain AK, Chen HH. ROSE-AHF and lessons learned. Curr Heart Fail Rep. 2014 Sep; 11 (3):260-5
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60. Dandamudi S, Slusser J, Mahoney DW, Redfield MM, Rodeheffer RJ, Chen HH. The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota. J Card Fail. 2014 May; 20 (5):304-9 Epub 2014 Feb 24
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61. Wan SH, Vogel MW, Chen HH. Pre-clinical diastolic dysfunction. J Am Coll Cardiol. 2014 Feb 11; 63 (5):407-16 Epub 2013 Nov 27
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62. McKie PM, Cataliotti A, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC Jr. M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics. J Am Heart Assoc. 2014 Jan 2; 3 (1):e000206 Epub 2014 Jan 02
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63. Pan S, Chen HH, Correia C, Dai H, Witt TA, Kleppe LS, Burnett JC Jr, Simari RD. Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate. PLoS One. 2014; 9(11):e112986. Epub 2014 Nov 24.
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64. Hoffmann LS, Chen HH. cGMP: Transition from bench to bedside: A report of the 6th International Conference on cGMP Generators, Effectors and Therapeutic Implications. Naunyn-Schmiedeberg's Archives of Pharmacology. 2014; 387:707-18.
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65. Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Davila-Roman VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM, NHLBI Heart Failure Clinical Research Network. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013 Dec 18; 310 (23):2533-43
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66. Chen HH, AbouEzzeddine OF, Anstrom KJ, Givertz MM, Bart BA, Felker GM, Hernandez AF, Lee KL, Braunwald E, Redfield MM, Heart Failure Clinical Research Network. Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial. Circ Heart Fail. 2013 Sep 1; 6 (5):1087-94
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67. Sangaralingham SJ, Burnett JC Jr, McKie PM, Schirger JA, Chen HH. Rationale and design of a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy of B-type natriuretic peptide for the preservation of left ventricular function after anterior myocardial infarction. J Card Fail. 2013 Aug; 19 (8):533-9
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68. Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, LeWinter MM, Rouleau JL, Bull DA, Mann DL, Deswal A, Stevenson LW, Givertz MM, Ofili EO, O'Connor CM, Felker GM, Goldsmith SR, Bart BA, McNulty SE, Ibarra JC, Lin G, Oh JK, Patel MR, Kim RJ, Tracy RP, Velazquez EJ, Anstrom KJ, Hernandez AF, Mascette AM, Braunwald E, RELAX Trial. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013 Mar 27; 309 (12):1268-77
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69. Ng XW, Huang Y, Chen HH, Burnett JC Jr, Boey FY, Venkatraman SS. Cenderitide-eluting film for potential cardiac patch applications. PLoS One. 2013; 8(7):e68346. Epub 2013 Jul 04.
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70. Lim SG, Venkatraman SS, Burnett JC Jr, Chen HH. In-vivo evaluation of an in situ polymer precipitation delivery system for a novel natriuretic peptide. PLoS One. 2013; 8(2):e52484. Epub 2013 Feb 18.
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71. Bart BA, Goldsmith SR, Lee KL, Givertz MM, O'Connor CM, Bull DA, Redfield MM, Deswal A, Rouleau JL, LeWinter MM, Ofili EO, Stevenson LW, Semigran MJ, Felker GM, Chen HH, Hernandez AF, Anstrom KJ, McNulty SE, Velazquez EJ, Ibarra JC, Mascette AM, Braunwald E, Heart Failure Clinical Research Network. Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med. 2012 Dec 13; 367(24):2296-304. Epub 2012 Nov 06.
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72. Chen HH, Glockner JF, Schirger JA, Cataliotti A, Redfield MM, Burnett JC Jr. Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide. J Am Coll Cardiol. 2012 Dec 4; 60 (22):2305-12 Epub 2012 Nov 01
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73. Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM. Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J. 2012 Nov; 164 (5):763-770.e3 Epub 2012 Oct 16
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74. Macheret F, Heublein D, Costello-Boerrigter LC, Boerrigter G, McKie P, Bellavia D, Mangiafico S, Ikeda Y, Bailey K, Scott CG, Sandberg S, Chen HH, Malatino L, Redfield MM, Rodeheffer R, Burnett J Jr, Cataliotti A. Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP. J Am Coll Cardiol. 2012 Oct 16; 60 (16):1558-65
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75. Dandamudi S, Chen HH. The ASCEND-HF trial: an acute study of clinical effectiveness of nesiritide and decompensated heart failure. Expert Rev Cardiovasc Ther. 2012 May; 10(5):557-63.
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76. Clements IP, Akerem Khan SK, Chen HH, Mullan BP. Measurement of left and right ventricular volumes with tomographic equilibrium radionuclide angiocardiography and cardiac MRI. Nucl Med Commun. 2012 May; 33: (5)481-5.
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77. Bart BA, Goldsmith SR, Lee KL, Redfield MM, Felker GM, O'Connor CM, Chen HH, Rouleau JL, Givertz MM, Semigran MJ, Mann D, Deswal A, Bull DA, Lewinter MM, Braunwald E. Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network. J Card Fail. 2012 Mar; 18(3):176-82. Epub 2012 Feb 02.
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78. Vogel MW, Slusser JP, Hodge DO, Chen HH. The natural history of preclinical diastolic dysfunction: a population-based study. Circ Heart Fail. 2012 Mar 1; 5 (2):144-51 Epub 2012 Jan 25
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79. Martin FL, McKie PM, Cataliotti A, Sangaralingham SJ, Korinek J, Huntley BK, Oehler EA, Harders GE, Ichiki T, Mangiafico S, Nath KA, Redfield MM, Chen HH, Burnett JC Jr. Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15; 302 (2):R292-9 Epub 2011 Nov 09
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80. Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett JC Jr. CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS One. 2012; 7 (12):e52422 Epub 2012 Dec 18
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81. Dandamudi S, Chen HH. Evolving treatment strategies for management of cardiorenal syndrome. Curr Treat Options Cardiovasc Med. 2011 Dec; 13 (6):556-69
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82. McKie PM, Schirger JA, Costello-Boerrigter LC, Benike SL, Harstad LK, Bailey KR, Hodge DO, Redfield MM, Simari RD, Burnett JC Jr, Chen HH. Impaired natriuretic and renal endocrine response to acute volume expansion in pre-clinical systolic and diastolic dysfunction. J Am Coll Cardiol. 2011 Nov 8; 58 (20):2095-103
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83. Dong YX, Burnett JC Jr, Chen HH, Sandberg S, Yang YZ, Zhang Y, Chen PS, Cha YM. Effect of cardiac resynchronization therapy on broad neurohormone biomarkers in heart failure. J Interv Card Electrophysiol. 2011 Apr; 30 (3):241-9 Epub 2011 Feb 19
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84. Felker GM, Lee KL, Bull DA, Redfield MM, Stevenson LW, Goldsmith SR, LeWinter MM, Deswal A, Rouleau JL, Ofili EO, Anstrom KJ, Hernandez AF, McNulty SE, Velazquez EJ, Kfoury AG, Chen HH, Givertz MM, Semigran MJ, Bart BA, Mascette AM, Braunwald E, O'Connor CM, NHLBI Heart Failure Clinical Research Network. Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 2011 Mar 3; 364(9):797-805.
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85. Vogel MW, Chen HH. Novel natriuretic peptides: new compounds and new approaches. Curr Heart Fail Rep. 2011 Mar; 8 (1):22-7
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86. Sangaralingham SJ, Huntley BK, Martin FL, McKie PM, Bellavia D, Ichiki T, Harders GE, Chen HH, Burnett JC Jr. The aging heart, myocardial fibrosis, and its relationship to circulating C-type natriuretic Peptide. Hypertension. 2011 Feb; 57 (2):201-7 Epub 2010 Dec 28
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87. McKie PM, Cataliotti A, Boerrigter G, Chen HH, Sangaralingham SJ, Martin FL, Ichiki T, Burnett JC Jr. A novel atrial natriuretic peptide based therapeutic in experimental angiotensin II mediated acute hypertension. Hypertension. 2010 Dec; 56 (6):1152-9 Epub 2010 Oct 25
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88. Huntley BK, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC Jr. B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts. J Cell Physiol. 2010 Oct; 225 (1):251-5
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89. Boilson BA, Larsen K, Harbuzariu A, Delacroix S, Korinek J, Froehlich H, Bailey KR, Scott CG, Shapiro BP, Boerrigter G, Chen HH, Redfield MM, Burnett JC Jr, Simari RD. Regulation of circulating progenitor cells in left ventricular dysfunction. Circ Heart Fail. 2010 Sep; 3 (5):635-42 Epub 2010 June 23
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90. Correa de Sa DD, Hodge DO, Slusser JP, Redfield MM, Simari RD, Burnett JC, Chen HH. Progression of preclinical diastolic dysfunction to the development of symptoms. Heart. 2010 Apr; 96 (7):528-32
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91. From AM, Scott CG, Chen HH. The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study. J Am Coll Cardiol. 2010 Jan 26; 55 (4):300-5
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96. Chen HH, Cataliotti A, Schirger JA, Martin FL, Harstad LK, Burnett JC Jr. Local renal delivery of a natriuretic peptide a renal-enhancing strategy for B-type natriuretic peptide in overt experimental heart failure. J Am Coll Cardiol. 2009 Apr 14; 53 (15):1302-8
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99. Martin FL, Chen HH, Cataliotti A, Burnett JC Jr. B-type natriuretic peptide: beyond a diagnostic. Heart Fail Clin. 2008 Oct; 4 (4):449-54
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100. Mohammed SF, Korinek J, Chen HH, Burnett JC, Redfield MM. Nesiritide in acute decompensated heart failure: current status and future perspectives. Rev Cardiovasc Med. 2008 Summer; 9 (3):151-8
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101. Owan TE, Chen HH, Frantz RP, Karon BL, Miller WL, Rodeheffer RJ, Hodge DO, Burnett JC Jr, Redfield MM. The effects of nesiritide on renal function and diuretic responsiveness in acutely decompensated heart failure patients with renal dysfunction. J Card Fail. 2008 May; 14 (4):267-75
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102. de Sa DD, Chen HH. The role of natriuretic peptides in heart failure. Curr Cardiol Rep. 2008 May; 10 (3):182-9
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103. Martin FL, Supaporn T, Chen HH, Sandberg SM, Matsuda Y, Jougasaki M, Burnett JC Jr. Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure. Am J Physiol Regul Integr Comp Physiol. 2007 Oct; 293 (4):R1580-5 Epub 2007 Aug 01
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104. Chen HH, Sundt TM, Cook DJ, Heublein DM, Burnett JC Jr. Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: a double-blind placebo-controlled pilot study. Circulation. 2007 Sep 11; 116 (11 Suppl):I134-8
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105. Binder J, Ommen SR, Chen HH, Ackerman MJ, Tajik AJ, Jaffe AS. Usefulness of brain natriuretic peptide levels in the clinical evaluation of patients with hypertrophic cardiomyopathy. Am J Cardiol. 2007 Aug 15; 100: (4)712-4.
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106. Cataliotti A, Chen HH, James KD, Burnett JC Jr. Oral brain natriuretic peptide: a novel strategy for chronic protein therapy for cardiovascular disease. Trends Cardiovasc Med. 2007 Jan; 17(1):10-4.
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107. Chen HH, Schrier RW. Pathophysiology of volume overload in acute heart failure syndromes. Am J Med. 2006 Dec; 119(12 Suppl 1):S11-6.
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108. Chen HH, Schirger JA, Cataliotti A, Burnett JC Jr. Intact acute cardiorenal and humoral responsiveness following chronic subcutaneous administration of the cardiac peptide BNP in experimental heart failure. Eur J Heart Fail. 2006 Nov; 8(7):681-6. Epub 2006 Feb 03.
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110. Chen HH, Huntley BK, Schirger JA, Cataliotti A, Burnett JC Jr. Maximizing the renal cyclic 3'-5'-guanosine monophosphate system with type V phosphodiesterase inhibition and exogenous natriuretic peptide: a novel strategy to improve renal function in experimental overt heart failure. J Am Soc Nephrol. 2006 Oct; 17 (10):2742-7 Epub 2006 Aug 23
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112. Chen HH, Burnett JC Jr. Therapeutic potential for existing and novel forms of natriuretic peptides. Heart Fail Clin. 2006 Jul; 2(3):365-73.
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113. Cataliotti A, Chen HH, Redfield MM, Burnett JC Jr. Natriuretic peptides as regulators of myocardial structure and function: pathophysiologic and therapeutic implications. Heart Fail Clin. 2006 Jul; 2(3):269-76.
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114. Riter H, Redfield M, Burnett JC, Chen HH. Non-hypotensive low dose nesiritide has differential renal effects compared to standard dose nesiritide in patients with acute decompensated heart failure and renal dysfunction. J Am Coll Cardiol. 2006 Jun 6; 47(11):2334-5.
     
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116. Detaint D, Messika-Zeitoun D, Chen HH, Rossi A, Avierinos JF, Scott C, Burnett JC Jr, Enriquez-Sarano M. Association of B-type natriuretic peptide activation to left ventricular end-systolic remodeling in organic and functional mitral regurgitation. Am J Cardiol. 2006 Apr 1; 97 (7):1029-34 Epub 2006 Feb 28
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119. Chen HH, Cataliotti A, Schirger JA, Martin FL, Burnett JC Jr. Equimolar doses of atrial and brain natriuretic peptides and urodilatin have differential renal actions in overt experimental heart failure. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288 (5):R1093-7 Epub 2004 Dec 30
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120. Mirzoyev Z, Anavekar NS, Chen HH. Renal and humoral pathophysiological actions of angiotensin II in congestive heart failure. Timely Top Med Cardiovasc Dis. 2005 Apr 1; 9:E9 Epub 2005 Apr 01
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122. Krajicek BJ, Chen HH. 76-year-old woman with chest pain. Mayo Clin Proc. 2004 Nov; 79(11):1435-8.
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123. Cataliotti A, Boerrigter G, Costello-Boerrigter LC, Schirger JA, Tsuruda T, Heublein DM, Chen HH, Malatino LS, Burnett JC Jr. Brain natriuretic peptide enhances renal actions of furosemide and suppresses furosemide-induced aldosterone activation in experimental heart failure. Circulation. 2004 Apr 6; 109(13):1680-5. Epub 2004 Mar 15.
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124. Chen HH, Redfield MM, Nordstrom LJ, Horton DP, Burnett JC Jr. Subcutaneous administration of the cardiac hormone BNP in symptomatic human heart failure. J Card Fail. 2004 Apr; 10 (2):115-9
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125. Schirger JA, Chen HH, Jougasaki M, Lisy O, Boerrigter G, Cataliotti A, Burnett JC Jr. Endothelin A receptor antagonism in experimental congestive heart failure results in augmentation of the renin-angiotensin system and sustained sodium retention. Circulation. 2004 Jan 20; 109: (2)249-54.
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126. Chen HH, Redfield MM, Nordstrom LJ, Cataliotti A, Burnett JC Jr. Angiotensin II AT1 receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure. Am J Physiol Renal Physiol. 2003 May; 284(5):F1115-9.
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127. Shapiro BP, Chen HH, Burnett JC Jr, Redfield MM. Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure. Mayo Clin Proc. 2003 Apr; 78 (4):481-6
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128. Jougasaki M, Leskinen H, Larsen AM, Cataliotti A, Chen HH, Burnett JC Jr. Leukemia inhibitory factor is augmented in the heart in experimental heart failure. Eur J Heart Fail. 2003 Mar; 5(2):137-45.
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129. Tsuruda T, Boerrigter G, Huntley BK, Noser JA, Cataliotti A, Costello-Boerrigter LC, Chen HH, Burnett JC Jr. Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ Res. 2002 Dec 13; 91 (12):1127-34
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130. Chen HH, Lainchbury JG, Senni M, Bailey KR, Redfield MM. Diastolic heart failure in the community: clinical profile, natural history, therapy, and impact of proposed diagnostic criteria. J Card Fail. 2002 Oct; 8 (5):279-87
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131. Chen HH, Lainchbury JG, Burnett JC Jr. Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide. J Am Coll Cardiol. 2002 Sep 18; 40 (6):1186-91
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132. Chen HH, Lainchbury JG, Harty GJ, Burnett JC Jr. Maximizing the natriuretic peptide system in experimental heart failure: subcutaneous brain natriuretic peptide and acute vasopeptidase inhibition. Circulation. 2002 Feb 26; 105 (8):999-1003
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133. Tsuruda T, Jougasaki M, Boerrigter G, Huntley BK, Chen HH, D'Assoro AB, Lee SC, Larsen AM, Cataliotti A, Burnett JC Jr. Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor. Circ Res. 2002 Feb 8; 90 (2):128-34
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134. Cataliotti A, Boerrigter G, Chen HH, Jougasaki M, Costello LC, Tsuruda T, Lee SC, Malatino LS, Burnett JC Jr. Differential actions of vasopeptidase inhibition versus angiotensin-converting enzyme inhibition on diuretic therapy in experimental congestive heart failure. Circulation. 2002 Feb 5; 105 (5):639-44
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135. Chen HH, Cataliotti A, Burnett JC Jr. Role of the natriuretic peptides in the cardiorenal and humoral actions of omapatrilat: insights from experimental heart failure. Curr Hypertens Rep. 2001 Dec; 3 Suppl 2:S15-21
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136. Chen HH, Lainchbury JG, Matsuda Y, Harty GJ, Burnett JC Jr. Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure. Hypertension. 2001 Aug; 38 (2):187-91
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137. Chen HH, Grantham JA, Schirger JA, Jougasaki M, Redfield MM, Burnett JC Jr. Subcutaneous administration of brain natriuretic peptide in experimental heart failure. J Am Coll Cardiol. 2000 Nov 1; 36 (5):1706-12
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138. Chen HH, Burnett JC. Natriuretic peptides in the pathophysiology of congestive heart failure. Curr Cardiol Rep. 2000 May; 2 (3):198-205
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139. Chen HH, Oh KY, Terzic A, Burnett JC Jr. The modulating actions of sulfonylurea on atrial natriuretic peptide release in experimental acute heart failure. Eur J Heart Fail. 2000 Mar; 2 (1):33-40
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140. Schirger JA, Grantham JA, Kullo IJ, Jougasaki M, Wennberg PW, Chen HH, Lisy O, Miller V, Miller V, Simari RD, Burnett JC Jr. Vascular actions of brain natriuretic peptide: modulation by atherosclerosis and neutral endopeptidase inhibition. J Am Coll Cardiol. 2000 Mar 1; 35 (3):796-801
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142. Chen HH, Burnett JC Jr. The natriuretic peptides in heart failure: diagnostic and therapeutic potentials. Proc Assoc Am Physicians. 1999 Sep-Oct; 111 (5):406-16
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143. Lisy O, Jougasaki M, Heublein DM, Schirger JA, Chen HH, Wennberg PW, Burnett JC. Renal actions of synthetic dendroaspis natriuretic peptide. Kidney Int. 1999 Aug; 56 (2):502-8
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144. Schirger JA, Heublein DM, Chen HH, Lisy O, Jougasaki M, Wennberg PW, Burnett JC Jr. Presence of Dendroaspis natriuretic peptide-like immunoreactivity in human plasma and its increase during human heart failure. Mayo Clin Proc. 1999 Feb; 74 (2):126-30
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146. Chen HH, Burnett JC Jr. C-type natriuretic peptide: the endothelial component of the natriuretic peptide system. J Cardiovasc Pharmacol. 1998; 32 Suppl 3:S22-8
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147. Chen HH, Shields RC, Bardsley WT. 68-year-old man with anemia and renal failure. Mayo Clin Proc. 1996 Feb; 71 (2):197-200
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