Faculty

Mark A. Frye, M.D.

Publications

Singh B, Kung S, Poppe KA, Brown SL, Erickson C, Hale AM, Johnson BL, Jones KL, Pazdernik VK, Schak KM, Betcher HK, Moore KM, Ozerdem A, Veldic M, Frye MA, Bobo WV. Partial wake therapy and luminotherapy as an adjunct to usual care in hospitalized patients with depression - a pilot study. Psychiatry Res 2024 Jul; 337:115921 Epub 2024 Apr 25
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Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cruceanu C, Czerski PM, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisen L, Frye MA, Fullerton JM, Gallo C, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu YH, Jamain S, Jimenez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, Konig B, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy MJ, McElroy SL, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Novak T, Nothen MM, O'Donovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulte EC, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Streit F, Tekola-Ayele F, Thalamuthu A, Tortorella A, Turecki G, Veeh J, Vieta E, Viswanath B, Witt SH, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Rietschel M, Schulze TG, Baune BT. Exploring the genetics of lithium response in bipolar disorders. Int J Bipolar Disord. 2024 Jun 12; 12 (1):20 Epub 2024 June 12
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Ercis M, Sanchez-Ruiz JA, Webb LM, Solares-Bravo M, Betcher HK, Moore KM, Frye MA, Veldic M, Ozerdem A. Sex differences in effectiveness and adverse effects of mood stabilizers and antipsychotics: A systematic review. J Affect Disord. 2024 May 1; 352:171-192 Epub 2024 Feb 15
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Ercis M, Ozerdem A, Veldic M, Singh B, Coombes BJ, Biernacka JM, Lazaridis KN, Frye MA. Measuring the exposome in bipolar disorder. Bipolar Disord. 2024 May 1 Epub 2024 May 01
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Singh B, Parikh SV, Voort JLV, Pazdernik VK, Achtyes ED, Goes FS, Yocum AK, Nykamp L, Becerra A, Smart L, Greden JF, Bobo WV, Frye MA, Burdick KE, Ryan KA. Change in neurocognitive functioning in patients with treatment-resistant depression with serial intravenous ketamine infusions: The Bio-K multicenter trial. Psychiatry Res. 2024 May; 335:115829 Epub 2024 Feb 28
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Singh B, Vande Voort JL, Pazdernik VK, Frye MA, Kung S. Treatment-resistant depression patients with baseline suicidal ideation required more treatments to achieve therapeutic response with ketamine/esketamine. J Affect Disord. 2024 Apr 15; 351:534-540 Epub 2024 Jan 30
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Cavalcanti S, Lopez OA, Kung S, Vande Voort JL, Somers K, Frye MA, Singh B. A Case of Tachyphylaxis After Long-Term Intravenous Racemic Ketamine for Treatment-Resistant Depression. J Clin Psychopharmacol. 2024 Apr 10 [Epub ahead of print]
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Nunez NA, Jezzini-Martinez S, Ho AM, Gardea-Resendez M, Prokop LJ, Singh B, Robledo-Atilano PM, Romo-Nava F, Veldic M, McElroy SL, Frye MA, Cuellar-Barboza AB. Candidate gene polymorphisms and clinical implications of the use of psychostimulants in adults with mood or attentional deficit disorders: A systematic review Biomarkers in Neuropsychiatry. 2024.
Sanchez-Ruiz JA, Coombes BJ, Pazdernik VM, Melhuish Beaupre LM, Jenkins GD, Pendegraft RS, Batzler A, Ozerdem A, McElroy SL, Gardea-Resendez MA, Cuellar-Barboza AB, Prieto ML, Frye MA, Biernacka JM. Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data. Mol Psychiatry. 2024 Mar 28 [Epub ahead of print]
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Romo-Nava F, Awosika OO, Basu I, Blom TJ, Welge J, Datta A, Guillen A, Guerdjikova AI, Fleck DE, Georgiev G, Mori N, Patino LR, DelBello MP, McNamara RK, Buijs RM, Frye MA, McElroy SL. Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern. Mol Psychiatry. 2024 Mar; 29 (3):580-589 Epub 2023 Dec 20
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Parikh SV, Vande Voort JL, Yocum AK, Achtyes E, Goes FS, Nykamp L, Singh B, Lopez-Vives D, Sera CE, Maixner D, Tarnal V, Severe J, Bartek S, Tye SJ, Rico J, Stoppel CJ, Becerra A, Smart L, Miller CR, Frye MA, Greden JF, Bobo WV. Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression. J Affect Disord. 2024 Mar 1; 348:143-151 Epub 2023 Dec 22
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Ou AH, Rosenthal SB, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Del Zompo M, Degenhardt F, DePaulo JR, Etain B, Falkai P, Fellendorf FT, Ferensztajn-Rochowiak E, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hofmann A, Hou L, Jamain S, Jimenez E, Kahn JP, Kassem L, Kato T, Kittel-Schneider S, Konig B, Kuo PH, Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Maj M, Manchia M, Marie-Claire C, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, McMahon FJ, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, Osby U, Ozaki N, Papiol S, Perlis RH, Pisanu C, Potash JB, Pfennig A, Reich-Erkelenz D, Reif A, Reininghaus EZ, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulze TG, Schweizer BW, Seemuller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt S, Wray NR, Wright A, Young LT, Zandi PP, Kelsoe JR. Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. Transl Psychiatry. 2024 Feb 23; 14 (1):109
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Nunez NA, Coombes BJ, Beaupre LM, Ozerdem A, Resendez MG, Romo-Nava F, Bond DJ, Veldic M, Singh B, Moore KM, Betcher HK, Kung S, Prieto ML, Fuentes M, Ercis M, Miola A, Sanchez Ruiz JA, Jenkins G, Batzler A, Leung JG, Cuellar-Barboza A, Tye SJ, McElroy SL, Biernacka JM, Frye MA. Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder. Transl Psychiatry. 2024 Feb 13; 14 (1):93
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Nooraeen S, Croarkin PE, Geske JR, Shekunov J, Orth SS, Romanowicz M, Frye MA, Vande Voort JL. High Probability of Gene-Drug Interactions Associated with Medication Side Effects in Adolescent Depression: Results from a Randomized Controlled Trial of Pharmacogenetic Testing. J Child Adolesc Psychopharmacol. 2024 Feb; 34 (1):28-33
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Singh B, Yocum AK, Strawbridge R, Burdick KE, Millett CE, Peters AT, Sperry SH, Fico G, Vieta E, Verdolini N, Godin O, Leboyer M, Etain B, Tso IF, Coombes BJ, McInnis MG, Nierenberg AA, Young AH, Ashton MM, Berk M, Williams LJ, Keramatian K, Yatham LN, Overs BJ, Fullerton JM, Roberts G, Mitchell PB, Andreassen OA, Andreazza AC, Zandi PP, Pham D, Biernacka JM, Frye MA, FACE-BD Collaborators, The Global Bipolar Cohort Collaborative. Patterns of pharmacotherapy for bipolar disorder: A GBC survey. Bipolar Disord. 2024 Feb; 26 (1):22-32 Epub 2023 July 18
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Miola A, Frye MA, Tondo L, Baldessarini RJ. Current Status and Treatment of Rapid Cycling Bipolar Disorder. J Clin Psychopharmacol. 2024 Jan 17 [Epub ahead of print]
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Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Oedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR. Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Mol Psychiatry. 2024 Jan; 29 (1):6-19 Epub 2023 Mar 29
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Frye MA, Nemeroff CB. Pharmacogenomic testing for antidepressant treatment selection: lessons learned and roadmap forward. Neuropsychopharmacology. 2024 Jan; 49 (1):282-284 Epub 2023 Aug 07
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Breitinger S, Gardea-Resendez M, Langholm C, Xiong A, Laivell J, Stoppel C, Harper L, Volety R, Walker A, D'Mello R, Byun AJS, Zandi P, Goes FS, Frye M, Torous J. Digital Phenotyping for Mood Disorders: Methodology-Oriented Pilot Feasibility Study. J Med Internet Res. 2023 Dec 29; 25:e47006
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Langholm C, Breitinger S, Gray L, Goes F, Walker A, Xiong A, Stopel C, Zandi P, Frye MA, Torous J. Classifying and clustering mood disorder patients using smartphone data from a feasibility study. NPJ Digit Med. 2023 Dec 21; 6 (1):238
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Zai CC, Squassina A, Tiwari AK, Pisanu C, Pinna M, Pinna F, Meloni A, Paribello P, Carpiniello B, Tondo L, Frye MA, Biernacka JM, Coombes BJ, Kennedy JL, Manchia M. A genome-wide association study of antidepressant-induced mania. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20; 127:110800 Epub 2023 May 24
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Miola A, Gardea-Resendez M, Ortiz-Orendain J, Nunez NA, Ercis M, Coombes BJ, Salgado MF, Gruhlke PM, Michel I, Bostwick JM, McKean AJ, Ozerdem A, Frye MA. Factors associated with suicide attempts in the antecedent illness trajectory of bipolar disorder and schizophrenia. Int J Bipolar Disord. 2023 Dec 8; 11 (1):38 Epub 2023 Dec 08
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Amare AT, Thalamuthu A, Schubert KO, Fullerton JM, Ahmed M, Hartmann S, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hou L, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Hasler R, Richard-Lepouriel H, Perroud N, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Del Zompo M, DePaulo JR, Etain B, Jamain S, Falkai P, Forstner AJ, Frisen L, Frye MA, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Fallgatter AJ, Stegmaier S, Ethofer T, Biere S, Petrova K, Schuster C, Adorjan K, Budde M, Heilbronner M, Kalman JL, Kohshour MO, Reich-Erkelenz D, Schaupp SK, Schulte EC, Senner F, Vogl T, Anghelescu IG, Arolt V, Dannlowski U, Dietrich D, Figge C, Jager M, Lang FU, Juckel G, Konrad C, Reimer J, Schmauss M, Schmitt A, Spitzer C, von Hagen M, Wiltfang J, Zimmermann J, Andlauer TFM, Fischer A, Bermpohl F, Ritter P, Matura S, Gryaznova A, Falkenberg I, Yildiz C, Kircher T, Schmidt J, Koch M, Gade K, Trost S, Haussleiter IS, Lambert M, Rohenkohl AC, Kraft V, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Jimenez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, Konig B, Kusumi I, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nothen MM, Novak T, O'Donovan C, Ozaki N, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Veeh J, Witt SH, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Clark SR, Baune BT. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Mol Psychiatry. 2023 Dec; 28 (12):5251-5261 Epub 2023 July 11
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Ortiz-Orendain J, Gardea-Resendez M, Castiello-de Obeso S, Golebiowski R, Coombes B, Gruhlke PM, Michel I, Bostwick JM, Morgan RJ, Ozerdem A, Frye MA, McKean AJ. Antecedents to first episode psychosis and mania: Comparing the initial prodromes of schizophrenia and bipolar disorder in a retrospective population cohort. J Affect Disord. 2023 Nov 1; 340:25-32 Epub 2023 July 27
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Sanchez-Ruiz JA, Leibman NI, Larson NB, Jenkins GD, Ahmed AT, Nunez NA, Biernacka JM, Winham SJ, Weinshilboum RM, Wang L, Frye MA, Ozerdem A. Age-Dependent Sex Differences in the Prevalence of Selective Serotonin Reuptake Inhibitor Treatment: A Retrospective Cohort Analysis. J Womens Health (Larchmt). 2023 Nov; 32 (11):1229-1240 Epub 2023 Oct 19
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Cuellar-Barboza AB, Prieto ML, Coombes BJ, Gardea-Resendez M, Nunez N, Winham SJ, Romo-Nava F, Gonzalez S, McElroy SL, Frye MA, Biernacka JM. Polygenic prediction of bipolar disorder in a Latin American sample. Am J Med Genet B Neuropsychiatr Genet. 2023 Oct-Dec; 192 (7-8):139-146 Epub 2023 Mar 15
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Docherty AR, Mullins N, Ashley-Koch AE, Qin X, Coleman JRI, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos AI, DiBlasi E, Fullerton JM, Kranzler HR, Bakian AV, Monson ET, Renteria ME, Walss-Bass C, Andreassen OA, Behera C, Bulik CM, Edenberg HJ, Kessler RC, Mann JJ, Nurnberger JI Jr, Pistis G, Streit F, Ursano RJ, Polimanti R, Dennis M, Garrett M, Hair L, Harvey P, Hauser ER, Hauser MA, Huffman J, Jacobson D, Madduri R, McMahon B, Oslin DW, Trafton J, Awasthi S, Berrettini WH, Bohus M, Chang X, Chen HC, Chen WJ, Christensen ED, Crow S, Duriez P, Edwards AC, Fernandez-Aranda F, Galfalvy H, Gandal M, Gorwood P, Guo Y, Hafferty JD, Hakonarson H, Halmi KA, Hishimoto A, Jain S, Jamain S, Jimenez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Kim M, Klump KL, Levey DF, Li D, Liao SC, Lieb K, Lilenfeld L, Marshall CR, Mitchell JE, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su MH, Thornton LM, Treasure J, Ware EB, Watson HJ, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Appadurai V, Artigas MS, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Castelao E, Cervilla JA, Chaumette B, Corvin A, Craddock N, Djurovic S, Foo JC, Forstner AJ, Frye M, Gatt JM, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamshere ML, Hartmann AM, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Krebs MO, Landen M, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Mehta D, Melle I, Mitchell PB, Molina E, Morken G, Nievergelt C, Nothen MM, O'Donovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribases M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Trzaskowski M, Tsuang MT, Turecki G, Vilar-Ribo L, Vincent JB, Volzke H, Walters JTR, Weickert CS, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Agerbo E, Borglum AD, Breen G, Demontis D, Erlangsen A, Gelernter J, Glatt SJ, Hougaard DM, Hwu HG, Kuo PH, Lewis CM, Li QS, Liu CM, Martin NG, McIntosh AM, Medland SE, Mors O, Nordentoft M, Olsen CM, Porteous D, Smith DJ, Stahl EA, Stein MB, Wasserman D, Werge T, Whiteman DC, Willour V, Coon H, Beckham JC, Kimbrel NA, Ruderfer DM, VA Million Veteran Program (MVP)//MVP Suicide Exemplar Workgroup//Suicide Working Group of the Psychiatric Genomics Consortium//Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium//Bipolar Disorder Working Group of the Psychiatric Genomics Consortium//Schizophrenia Worki. GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. Am J Psychiatry. 2023 Oct 1; 180 (10):723-738
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Burdick KE, Millett CE, Yocum AK, Altimus CM, Andreassen OA, Aubin V, Belzeaux R, Berk M, Biernacka JM, Blumberg HP, Cleare AJ, Diaz-Byrd C, Dubertret C, Etain B, Eyler LT, Forester BP, Fullerton JM, Frye MA, Gard S, Godin O, Haffen E, Klaus F, Lagerberg TV, Leboyer M, Martinez-Aran A, McElroy S, Mitchell PB, Olie E, Olorunfemi P, Passerieux C, Peters AT, Pham DL, Polosan M, Potter JR, Sajatovic M, Samalin L, Schwan R, Shanahan M, Sole B, Strawbridge R, Stuart AL, Torres I, Ueland T, Vieta E, Williams LJ, Wrobel AL, Yatham LN, Young AH, Nierenberg AA, McInnis MG. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative. Focus (Am Psychiatr Publ). 2023 Oct; 21 (4):444-452 Epub 2023 Oct 15
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Mishra HK, Wei H, Rohr KE, Ko I, Nievergelt CM, Maihofer AX, Shilling PD, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye M, Gage F, Gershon E, McInnis MG, Nurnberger J, Oedegaard KJ, Zandi PP, Kelsoe JR, McCarthy MJ. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. Eur Neuropsychopharmacol. 2023 Sep; 74:1-14 Epub 2023 Apr 29
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Nunez NA, Coombes BJ, Melhuish Beaupre L, Romo-Nava F, Gardea-Resendez M, Ozerdem A, Veldic M, Singh B, Sanchez Ruiz JA, Cuellar-Barboza A, Leung JG, Prieto ML, McElroy SL, Biernacka JM, Frye MA. Antidepressant-Associated Treatment Emergent Mania: A Meta-Analysis to Guide Risk Modeling Pharmacogenomic Targets of Potential Clinical Value. J Clin Psychopharmacol. 2023 Aug 16; 43 (5):428-33 [Epub ahead of print]
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Miola A, Alvarez-Villalobos NA, Ruiz-Hernandez FG, De Filippis E, Veldic M, Prieto ML, Singh B, Sanchez Ruiz JA, Nunez NA, Resendez MG, Romo-Nava F, McElroy SL, Ozerdem A, Biernacka JM, Frye MA, Cuellar-Barboza AB. Insulin resistance in bipolar disorder: A systematic review of illness course and clinical correlates. J Affect Disord. 2023 Aug 1; 334:1-11 Epub 2023 Apr 21
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Romo-Nava F, Blom T, Cuellar-Barboza AB, Barrera FJ, Miola A, Mori NN, Prieto ML, Veldic M, Singh B, Gardea-Resendez M, Nunez NA, Ozerdem A, Biernacka JM, Frye MA, McElroy SL. Clinical characterization of patients with bipolar disorder and a history of asthma: An exploratory study. J Psychiatr Res. 2023 Aug; 164:8-14 Epub 2023 June 03
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Miola A, Fountoulakis KN, Baldessarini RJ, Veldic M, Solmi M, Rasgon N, Ozerdem A, Perugi G, Frye MA, Preti A. Prevalence and outcomes of rapid cycling bipolar disorder: Mixed method systematic meta-review. J Psychiatr Res. 2023 Aug; 164:404-415 Epub 2023 June 25
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Kumar R, LeMahieu AM, Stan MN, Seshadri A, Ozerdem A, Pazdernik VK, Haynes TL, Daugherty DH 3rd, Sundaresh V, Veldic M, Croarkin PE, Frye MA, Singh B. The Association Between Thyroid Stimulating Hormone and Depression: A Historical Cohort Study. Mayo Clin Proc. 2023 Jul; 98 (7):1009-1020
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Bauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Altinbas K, Andreassen OA, Angelopoulos E, Ardau R, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, Balaban C, Becerra-Palars C, Behere AP, Behere PB, Belete H, Belete T, Belizario GO, Bellivier F, Belmaker RH, Benedetti F, Berk M, Bersudsky Y, Bicakci S, Birabwa-Oketcho H, Bjella TD, Brady C, Cabrera J, Cappucciati M, Castro AMP, Chen WL, Cheung EYW, Chiesa S, Crowe M, Cuomo A, Dallaspezia S, Del Zompo M, Desai P, Dodd S, Etain B, Fagiolini A, Fellendorf FT, Ferensztajn-Rochowiak E, Fiedorowicz JG, Fountoulakis KN, Frye MA, Geoffroy PA, Gitlin MJ, Gonzalez-Pinto A, Gottlieb JF, Grof P, Haarman BCM, Harima H, Hasse-Sousa M, Henry C, Hoffding L, Houenou J, Imbesi M, Isometsa ET, Ivkovic M, Janno S, Johnsen S, Kapczinski F, Karakatsoulis GN, Kardell M, Kessing LV, Kim SJ, Konig B, Kot TL, Koval M, Kunz M, Lafer B, Landen M, Larsen ER, Lenger M, Licht RW, Lopez-Jaramillo C, MacKenzie A, Madsen HO, Madsen SAKA, Mahadevan J, Mahardika A, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Martini J, Martiny K, Mashima Y, McLoughlin DM, Meesters Y, Melle I, Meza-Urzua F, Mikolas P, Mok YM, Monteith S, Moorthy M, Morken G, Mosca E, Mozzhegorov AA, Munoz R, Mythri SV, Nacef F, Nadella RK, Nakanotani T, Nielsen RE, O'Donovan C, Omrani A, Osher Y, Ouali U, Pantovic-Stefanovic M, Pariwatcharakul P, Petite J, Petzold J, Pfennig A, Ruiz YP, Pinna M, Pompili M, Porter RJ, Quiroz D, Rabelo-da-Ponte FD, Ramesar R, Rasgon N, Ratta-Apha W, Ratzenhofer M, Redahan M, Reddy MS, Reif A, Reininghaus EZ, Richards JG, Ritter P, Rybakowski JK, Sathyaputri L, Scippa AM, Simhandl C, Smith D, Smith J, Stackhouse PW Jr, Stein DJ, Stilwell K, Strejilevich S, Su KP, Subramaniam M, Sulaiman AH, Suominen K, Tanra AJ, Tatebayashi Y, Teh WL, Tondo L, Torrent C, Tuinstra D, Uchida T, Vaaler AE, Vieta E, Viswanath B, Yoldi-Negrete M, Yalcinkaya OK, Young AH, Zgueb Y, Whybrow PC. Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder. Int J Bipolar Disord. 2023 Jun 22; 11 (1):22 Epub 2023 June 22
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Singh B, Vande Voort JL, Riva-Posse P, Pazdernik VM, Frye MA, Tye SJ. Ketamine-Associated Change in Anhedonia and mTOR Expression in Treatment-Resistant Depression. Biol Psychiatry 2023 Jun 15; 93 (12):e65-e68 Epub 2023 Jan 25
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Sanchez Ruiz JA, Coombes BJ, Pendegraft RS, Ozerdem A, McElroy SL, Cuellar-Barboza AB, Prieto ML, Frye MA, Winham SJ, Biernacka JM. Pharmacotherapy exposure as a marker of disease complexity in bipolar disorder: Associations with clinical & genetic risk factors. Psychiatry Res. 2023 May; 323:115174 Epub 2023 Mar 21
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Price JB, Bronars C, Erhardt S, Cullen KR, Schwieler L, Berk M, Walder K, McGee SL, Frye MA, Tye SJ. Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression. Neurosci Biobehav Rev. 2018 Jul; 90:212-220 Epub 2018 Apr 12
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Ahmed AT, Weinshilboum R, Frye MA. Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder. Clin Pharmacol Ther. 2018 May; 103 (5):767-769 Epub 2018 Feb 01
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McElroy SL, Winham SJ, Cuellar-Barboza AB, Colby CL, Ho AM, Sicotte H, Larrabee BR, Crow S, Frye MA, Biernacka JM. Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. Transl Psychiatry. 2018 Feb 2; 8 (1):40 Epub 2018 Feb 02
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Nassan M, Jia YF, Jenkins G, Colby C, Feeder S, Choi DS, Veldic M, McElroy SL, Bond DJ, Weinshilboum R, Biernacka JM, Frye MA. Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach. J Psychiatr Res. 2017 Dec; 95:208-212 Epub 2017 July 04
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Blacker CJ, Lewis CP, Frye MA, Veldic M. Metabotropic glutamate receptors as emerging research targets in bipolar disorder. Psychiatry Res. 2017 Nov; 257:327-337 Epub 2017 July 31
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Croarkin PE, Luby JL, Cercy K, Geske JR, Veldic M, Simonson M, Joshi PT, Wagner KD, Walkup JT, Nassan MM, Cuellar-Barboza AB, Casuto L, McElroy SL, Jensen PS, Frye MA, Biernacka JM. Genetic Risk Score Analysis in Early-Onset Bipolar Disorder. J Clin Psychiatry. 2017 Nov-Dec; 78 (9):1337-1343
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Riemann G, Weisscher N, Post RM, Altshuler L, McElroy S, Frye MA, Keck PE Jr, Leverich GS, Suppes T, Grunze H, Nolen WA, Kupka RW. The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder. Int J Bipolar Disord. 2017 Sep 25; 5 (1):31 Epub 2017 Sept 25
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Lapid MI, Kung S, Frye MA, Biernacka JM, Geske JR, Drake MT, Jankowski MD, Clarke BL. Association of the serotonin transporter-linked polymorphic region genotype with lower bone mineral density. Transl Psychiatry. 2017 Aug 22; 7 (8):e1213
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Witt SH, Streit F, Jungkunz M, Frank J, Awasthi S, Reinbold CS, Treutlein J, Degenhardt F, Forstner AJ, Heilmann-Heimbach S, Dietl L, Schwarze CE, Schendel D, Strohmaier J, Abdellaoui A, Adolfsson R, Air TM, Akil H, Alda M, Alliey-Rodriguez N, Andreassen OA, Babadjanova G, Bass NJ, Bauer M, Baune BT, Bellivier F, Bergen S, Bethell A, Biernacka JM, Blackwood DHR, Boks MP, Boomsma DI, Borglum AD, Borrmann-Hassenbach M, Brennan P, Budde M, Buttenschon HN, Byrne EM, Cervantes P, Clarke TK, Craddock N, Cruceanu C, Curtis D, Czerski PM, Dannlowski U, Davis T, de Geus EJC, Di Florio A, Djurovic S, Domenici E, Edenberg HJ, Etain B, Fischer SB, Forty L, Fraser C, Frye MA, Fullerton JM, Gade K, Gershon ES, Giegling I, Gordon SD, Gordon-Smith K, Grabe HJ, Green EK, Greenwood TA, Grigoroiu-Serbanescu M, Guzman-Parra J, Hall LS, Hamshere M, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hitturlingappa S, Hoffmann P, Holmans P, Hottenga JJ, Jamain S, Jones I, Jones LA, Jureus A, Kahn RS, Kammerer-Ciernioch J, Kirov G, Kittel-Schneider S, Kloiber S, Knott SV, Kogevinas M, Landen M, Leber M, Leboyer M, Li QS, Lissowska J, Lucae S, Martin NG, Mayoral-Cleries F, McElroy SL, McIntosh AM, McKay JD, McQuillin A, Medland SE, Middeldorp CM, Milaneschi Y, Mitchell PB, Montgomery GW, Morken G, Mors O, Muhleisen TW, Muller-Myhsok B, Myers RM, Nievergelt CM, Nurnberger JI, O'Donovan MC, Loohuis LMO, Ophoff R, Oruc L, Owen MJ, Paciga SA, Penninx BWJH, Perry A, Pfennig A, Potash JB, Preisig M, Reif A, Rivas F, Rouleau GA, Schofield PR, Schulze TG, Schwarz M, Scott L, Sinnamon GCB, Stahl EA, Strauss J, Turecki G, Van der Auwera S, Vedder H, Vincent JB, Willemsen G, Witt CC, Wray NR, Xi HS, Tadic A, Dahmen N, Schott BH, Cichon S, Nothen MM, Ripke S, Mobascher A, Rujescu D, Lieb K, Roepke S, Schmahl C, Bohus M, Rietschel M, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium//Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium//Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl Psychiatry. 2017 Jun 20; 7 (6):e1155 Epub 2017 June 20
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Sanacora G, Frye MA, McDonald W, Mathew SJ, Turner MS, Schatzberg AF, Summergrad P, Nemeroff CB, American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments. A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry. 2017 Apr 1; 74 (4):399-405
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Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA. More childhood onset bipolar disorder in the United States than Canada or Europe: Implications for treatment and prevention. Neurosci Biobehav Rev. 2017 Mar; 74 (Pt A):204-213 Epub 2017 Jan 21
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Nassan M, Li Q, Croarkin PE, Chen W, Colby CL, Veldic M, McElroy SL, Jenkins GD, Ryu E, Cunningham JM, Leboyer M, Frye MA, Biernacka JM. A genome wide association study suggests the association of muskelin with early onset bipolar disorder: Implications for a GABAergic epileptogenic neurogenesis model. J Affect Disord. 2017 Jan 15; 208:120-129. Epub 2016 Sep 30.
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Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Nolen WA. Illnesses in siblings of US patients with bipolar disorder relate to multigenerational family history and patients severity of illness. J Affect Disord. 2017 Jan 1; 207:313-319 Epub 2016 Oct 06
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Frye MA, Ryu E, Nassan M, Jenkins GD, Andreazza AC, Evans JM, McElroy SL, Evans JM, Oglesbee D Jr, Highsmith WE, Biernacka JM. Mitochondrial DNA sequence data reveals association of haplogroup U with psychosis in bipolar disorder. J Psychiatr Res. 2017 Jan; 84:221-226 Epub 2016 Sept 30
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Athreya AP, Banerjee SS, Neavin D, Kaddurah-Daouk R, Rush AJ, Frye MA, Wang L, Weinshilboum RM, Bobo WV, Iyer RK. Data-driven longitudinal modeling and prediction of symptom dynamics in major depressive disorder: Integrating factor graphs and learning methods 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2017. 2017; 8058559
Jia YF, Choi Y, Ayers-Ringler JR, Biernacka JM, Geske JR, Lindberg DR, McElroy SL, Frye MA, Choi DS, Veldic M. Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction. Front Cell Neurosci. 2017; 11:217 Epub 2017 July 21
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Frye MA, English T. Lori Altshuler. Neuropsychopharmacology. 2016 Dec; 41 (13):3114-3115
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Schmidt KA, Palmer BA, Frye MA. Mixed mania associated with cessation of breastfeeding. Int J Bipolar Disord. 2016 Dec; 4 (1):18 Epub 2016 Sept 05
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Vande Voort JL, Morgan RJ, Kung S, Rasmussen KG, Rico J, Palmer BA, Schak KM, Tye SJ, Ritter MJ, Frye MA, Bobo WV. Continuation phase intravenous ketamine in adults with treatment-resistant depression. J Affect Disord. 2016 Dec; 206:300-304. Epub 2016 Sep 12.
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Frye MA, Hinton DJ, Karpyak VM, Biernacka JM, Gunderson LJ, Feeder SE, Choi DS, Port JD. Anterior Cingulate Glutamate Is Reduced by Acamprosate Treatment in Patients With Alcohol Dependence. J Clin Psychopharmacol. 2016 Dec; 36 (6):669-674
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Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo WV, Frye MA, Skime M, Jenkins GD, Batzler A, Kalari K, Matson W, Bhasin SS, Zhu H, Mushiroda T, Nakamura Y, Kubo M, Wang L, Kaddurah-Daouk R, Weinshilboum RM. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol Psychiatry. 2016 Dec; 21 (12):1717-1725 Epub 2016 Feb 23
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Gharacholou SM, Roger VL, Lennon RJ, Frye MA, Rihal CS, Singh M. Depressive symptom severity and mortality in older adults undergoing percutaneous coronary intervention. Int J Cardiol 2016 Oct 15; 221:521-3 Epub 2016 July 01
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Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA. Age at Onset of Bipolar Disorder Related to Parental and Grandparental Illness Burden. J Clin Psychiatry. 2016 Oct; 77 (10):e1309-e1315
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Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA. Age of onset of bipolar disorder: Combined effect of childhood adversity and familial loading of psychiatric disorders. J Psychiatr Res. 2016 Oct; 81:63-70 Epub 2016 June 16
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Miller S, Suppes T, Mintz J, Hellemann G, Frye MA, McElroy SL, Nolen WA, Kupka R, Leverich GS, Grunze H, Altshuler LL, Keck PE Jr, Post RM. Mixed Depression in Bipolar Disorder: Prevalence Rate and Clinical Correlates During Naturalistic Follow-Up in the Stanley Bipolar Network. Am J Psychiatry. 2016 Oct 1; 173 (10):1015-1023 Epub 2016 Apr 15
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Schmidt KA, Ho AMC, Frye MA, Choi DS. Association of plasma orexin-A and ethanol-drinking behaviors in pregnant rats. J Alcohol Drug Depend. 2016; 4(5).
McElroy SL, Crow S, Blom TJ, Cuellar-Barboza AB, Prieto ML, Veldic M, Winham SJ, Bobo WV, Geske J, Seymour LR, Mori N, Bond DJ, Biernacka JM, Frye MA. Clinical features of bipolar spectrum with binge eating behaviour. J Affect Disord. 2016 Sep 1; 201:95-8 Epub 2016 May 06
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Puffer CC, Wall CA, Huxsahl JE, Frye MA. A 20 Year Practice Review of Electroconvulsive Therapy for Adolescents. J Child Adolesc Psychopharmacol. 2016 Sep; 26 (7):632-6 Epub 2016 Jan 19
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Wall CA, Croarkin PE, Maroney-Smith MJ, Haugen LM, Baruth JM, Frye MA, Sampson SM, Port JD. Magnetic Resonance Imaging-Guided, Open-Label, High-Frequency Repetitive Transcranial Magnetic Stimulation for Adolescents with Major Depressive Disorder. J Child Adolesc Psychopharmacol. 2016 Sep; 26 (7):582-9 Epub 2016 Feb 05
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Prieto ML, Ryu E, Jenkins GD, Batzler A, Nassan MM, Cuellar-Barboza AB, Pathak J, McElroy SL, Frye MA, Biernacka JM. Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities. Transl Psychiatry. 2016 Aug 16; 6 (8):e870
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Post RM, Kupka R, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Rowe M, Grunze H, Suppes T, Leverich GS, Nolen WA. Further Evidence of a Cohort Effect in Bipolar Disorder: More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs. J Clin Psychiatry. 2016 Aug; 77 (8):1043-9
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Frye MA, Hinton DJ, Karpyak VM, Biernacka JM, Gunderson LJ, Geske J, Feeder SE, Choi DS, Port JD. Elevated Glutamate Levels in the Left Dorsolateral Prefrontal Cortex Are Associated with Higher Cravings for Alcohol. Alcohol Clin Exp Res. 2016 Aug; 40 (8):1609-16 Epub 2016 July 20
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Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landen M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L, Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Etain B, Falkai P, Foroud T, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn JP, Kassem L, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Koller DL, Konig B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Muhleisen TW, Nievergelt CM, Nothen MM, Novak T, Nurnberger JI Jr, Nwulia EA, Osby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. Hum Mol Genet. 2016 Aug 1; 25 (15):3383-3394 Epub 2016 June 21
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Bobo WV, Vande Voort JL, Croarkin PE, Leung JG, Tye SJ, Frye MA. KETAMINE FOR TREATMENT-RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE. Depress Anxiety. 2016 Aug; 33 (8):698-710 Epub 2016 Apr 06
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Karpyak VM, Biernacka JM, Geske JR, Abulseoud OA, Brunner MD, Chauhan M, Hall-Flavin DK, Lewis KA, Loukianova LL, Melnyk GJ, Onsrud DA, Proctor BD, Schneekloth TD, Skime MK, Wittkopp JE, Frye MA, Mrazek DA. Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states. Addiction. 2016 Aug; 111 (8):1366-75 Epub 2016 May 05
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Nassan M, Nicholson WT, Elliott MA, Rohrer Vitek CR, Black JL, Frye MA. Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine. Mayo Clin Proc. 2016 Jul; 91 (7):897-907 Epub 2016 June 21
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Ketter TA, Amchin J, Frye MA, Gross N. Long-term safety and efficacy of armodafinil in bipolar depression: A 6-month open-label extension study. J Affect Disord. 2016 Jun; 197:51-7 Epub 2016 Feb 27
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Kim Y, Morath B, Hu C, Byrne LK, Sutor SL, Frye MA, Tye SJ. Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex. Behav Brain Res. 2016 Jun 1; 306:170-7 Epub 2016 Mar 05
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Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 5; 16:129 Epub 2016 May 05
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Prieto ML, Schenck LA, Kruse JL, Klaas JP, Chamberlain AM, Bobo WV, Bellivier F, Leboyer M, Roger VL, Brown RD Jr, Rocca WA, Frye MA. Long-term risk of myocardial infarction and stroke in bipolar I disorder: A population-based Cohort Study. J Affect Disord. 2016 Apr; 194:120-7 Epub 2016 Jan 13
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Frey BN, Andreazza AC, Houenou J, Jamain S, Goldstein BI, Frye MA, Leboyer M, Berk M, Malhi GS, Lopez-Jaramillo C, Taylor VH, Dodd S, Frangou S, Hall GB, Fernandes BS, Kauer-Sant'Anna M, Yatham LN, Kapczinski F, Young LT. Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. Aust N Z J Psychiatry. 2013 Apr; 47: (4)321-32.
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Kung S, Alarcon RD, Williams MD, Poppe KA, Jo Moore M, Frye MA. Comparing the Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire (PHQ-9) depression measures in an integrated mood disorders practice. J Affect Disord. 2013 Mar 5; 145 (3):341-3 Epub 2012 Sept 25
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Abulseoud OA, Gitlin M, Altshuler L, Frye MA. Baseline thyroid indices and the subsequent response to citalopram treatment, a pilot study. Brain Behav. 2013 Mar; 3 (2):89-94 Epub 2013 Jan 18
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Lapid MI, Drake MT, Geske JR, Mundis CB, Hegard TL, Kung S, Frye MA. Hypovitaminosis D in psychogeriatric inpatients. J Nutr Health Aging. 2013 Mar; 17 (3):231-4
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Post RM, Chang K, Frye MA. Paradigm shift: preliminary clinical categorization of ultrahigh risk for childhood bipolar disorder to facilitate studies on prevention. J Clin Psychiatry. 2013 Feb; 74: (2)167-9.
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Biernacka JM, Geske JR, Schneekloth TD, Frye MA, Cunningham JM, Choi DS, Tapp CL, Lewis BR, Drews MS, L Pietrzak T, Colby CL, Hall-Flavin DK, Loukianova LL, Heit JA, Mrazek DA, Karpyak VM. Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. PLoS One. 2013; 8 (3):e58798 Epub 2013 Mar 13
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Knight EJ, Min HK, Hwang SC, Marsh MP, Paek S, Kim I, Felmlee JP, Abulseoud OA, Bennet KE, Frye MA, Lee KH. Nucleus accumbens deep brain stimulation results in insula and prefrontal activation: a large animal FMRI study. PLoS One. 2013; 8 (2):e56640 Epub 2013 Feb 18
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Swann AC, Lafer B, Perugi G, Frye MA, Bauer M, Bahk WM, Scott J, Ha K, Suppes T. Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis. Am J Psychiatry. 2013 Jan; 170: (1)31-42.
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Leboyer M, Soreca I, Scott J, Frye M, Henry C, Tamouza R, Kupfer DJ. Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord. 2012 Dec 01; 141: (1)1-10.
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Chopra A, Tye SJ, Lee KH, Sampson S, Matsumoto J, Adams A, Klassen B, Stead M, Fields JA, Frye MA. Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. J Neuropsychiatry Clin Neurosci. 2012 Winter; 24 (1):102-10
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Schneekloth TD, Biernacka JM, Hall-Flavin DK, Karpyak VM, Frye MA, Loukianova LL, Stevens SR, Drews MS, Geske JR, Mrazek DA. Alcohol craving as a predictor of relapse. Am J Addict. 2012 Nov; 21 Suppl 1:S20-6.
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Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez-Pinto A, Henry C, Kapczinski F, Kliwicki S, Konig B, Kunz M, Lafer B, Lopez-Jaramillo C, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Melle I, Morken G, Munoz R, Nery FG, O'Donovan C, Pfennig A, Quiroz D, Rasgon N, Reif A, Rybakowski J, Sagduyu K, Simhandl C, Torrent C, Vieta E, Zetin M, Whybrow PC. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord. 2012 Sep; 14: (6)654-63.
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Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray JA, Berk M, Tye SJ. Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neurosci Biobehav Rev. 2012 Sep; 36(8):1920-33. Epub 2012 Jun 18.
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Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Rowe M, Kupka RW, Grunze H, Goodwin FK. Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients. J Clin Psychiatry. 2012 Jul; 73: (7)924-30.
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Hinton DJ, Lee MR, Jacobson TL, Mishra PK, Frye MA, Mrazek DA, Macura SI, Choi DS. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1. Neuropharmacology. 2012 Jun; 62 (8):2480-8
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Malhi GS, Bargh DM, Cashman E, Frye MA, Gitlin M. The clinical management of bipolar disorder complexity using a stratified model. Bipolar Disord. 2012 May; 14 Suppl 2:66-89.
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Gitlin M, Frye MA. Maintenance therapies in bipolar disorders. Bipolar Disord. 2012 May; 14 Suppl 2:51-65.
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Malhi GS, Bargh DM, McIntyre R, Gitlin M, Frye MA, Bauer M, Berk M. Balanced efficacy, safety, and tolerability recommendations for the clinical management of bipolar disorder. Bipolar Disord. 2012 May; 14 Suppl 2:1-21.
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Chopra A, Kolla BP, Mansukhani MP, Netzel P, Frye MA. Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management. Gen Hosp Psychiatry. 2012 May-Jun; 34 (3):290-8 Epub 2012 Feb 02
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Lapid MI, Drake MT, Geske JR, Mundis CB, Hegard TL, Kung S, Frye MA. Hypovitaminosis D in psychogeriatric inpatients J Nutr Health Aging.2012;
Li X, Frye MA, Shelton RC. Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology. 2012 Jan; 37: (1)77-101.
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Biernacka JM, McElroy SL, Crow S, Sharp A, Benitez J, Veldic M, Kung S, Cunningham JM, Post RM, Mrazek D, Frye MA. Pharmacogenomics of antidepressant induced mania: a review and meta-analysis of the serotonin transporter gene (5HTTLPR) association. J Affect Disord. 2012 Jan; 136 (1-2):e21-e29 Epub 2011 June 15
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Kolla BP, Schneekloth TD, Biernacka JM, Frye MA, Mansukhani MP, Hall-Flavin DK, Karpyak VM, Loukianova LL, Lesnick TG, Mrazek D. Trazodone and alcohol relapse: a retrospective study following residential treatment. Am J Addict. 2011 Nov-Dec; 20 (6):525-9 Epub 2011 Sept 29
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Shippee ND, Shah ND, Williams MD, Moriarty JP, Frye MA, Ziegenfuss JY. Differences in demographic composition and in work, social, and functional limitations among the populations with unipolar depression and bipolar disorder: results from a nationally representative sample. Health Qual Life Outcomes. 2011 Oct 13; 9:90
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Frye MA, Ha K, Kanba S, Kato T, McElroy SL, Ozerdem A, Vazquez G, Vieta E. International consensus group on depression prevention in bipolar disorder. J Clin Psychiatry 2011 Oct; 72 (10):1295-310
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Williams MD, Shah ND, Wagie AE, Wood DL, Frye MA. Direct costs of bipolar disorder versus other chronic conditions: an employer-based health plan analysis. Psychiatr Serv. 2011 Sep; 62(9):1073-8.
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Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J, Rowe M. Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany. Int Clin Psychopharmacol. 2011 Mar; 26: (2)96-106.
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McElroy SL, Frye MA, Hellemann G, Altshuler L, Leverich GS, Suppes T, Keck PE, Nolen WA, Kupka R, Post RM. Prevalence and correlates of eating disorders in 875 patients with bipolar disorder. J Affect Disord. 2011 Feb; 128: (3)191-8.
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Frye MA. Clinical practice. Bipolar disorder--a focus on depression. N Engl J Med. 2011 Jan 6; 364 (1):51-9
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Hall-Flavin DK, Schneekloth TD, Loukianova LL, Karpyak VM, Lesnick TG, Biernacka JM, Mrazek DA, Frye MA. Utilization of residential alcoholism treatment in bipolar disorder. Am J Addict. 2011 Jan-Feb; 20 (1):40-4 Epub 2010 Nov 12
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Calabrese JR, Ketter TA, Youakim JM, Tiller JM, Yang R, Frye MA. Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study. J Clin Psychiatry. 2010 Oct; 71: (10)1363-70.
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Post RM, Altshuler LL, Frye MA, Suppes T, Keck PE Jr, McElroy SL, Leverich GS, Luckenbaugh DA, Rowe M, Pizzarello S, Kupka RW, Grunze H, Nolen WA. Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder. J Clin Psychiatry. 2010 Sep; 71: (9)1176-86; quiz 1252-3.
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Gitlin MJ, Abulseoud O, Frye MA. Improving the design of maintenance studies for bipolar disorder. Curr Med Res Opin. 2010 Aug; 26(8):1835-42.
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Post RM, Leverich GS, Kupka RW, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA. Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. J Clin Psychiatry. 2010 Jul; 71: (7)864-72.
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Boykoff N, Schneekloth TD, Hall-Flavin D, Loukianova L, Karpyak VM, Stevens SR, Biernacka JM, Mrazek DA, Frye MA. Gender differences in the relationship between depressive symptoms and cravings in alcoholism. Am J Addict. 2010 Jul-Aug; 19 (4):352-6
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Altshuler LL, Kupka RW, Hellemann G, Frye MA, Sugar CA, McElroy SL, Nolen WA, Grunze H, Leverich GS, Keck PE, Zermeno M, Post RM, Suppes T. Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network. Am J Psychiatry. 2010 Jun; 167: (6)708-15.
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Frye MA. Treatment guidelines for acute manic and mixed episodes of bipolar disorder. Cns Spectrums. 2009 Dec; 14(Suppl 15):8-11.
Benazzi F, Berk M, Frye MA, Wang W, Barraco A, Tohen M. Olanzapinefluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis. J Clin Psychiatry. 2009 Oct; 70: (10)1424-31.
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Goldberg JF, Calabrese JR, Saville BR, Frye MA, Ketter TA, Suppes T, Post RM, Goodwin FK. Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo. J Clin Psychiatry. 2009 Sep; 70: (9)1273-80.
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Frye MA, Yatham L, Ketter TA, Goldberg J, Suppes T, Calabrese JR, Bowden CL, Bourne E, Bahn RS, Adams B. Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies. Acta Psychiatr Scand. 2009 Jul; 120 (1):10-3 Epub 2009 Jan 31
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Tye SJ, Frye MA, Lee KH. Disrupting disordered neurocircuitry: treating refractory psychiatric illness with neuromodulation. Mayo Clin Proc. 2009 Jun; 84 (6):522-32
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Altshuler LL, Post RM, Hellemann G, Leverich GS, Nolen WA, Frye MA, Keck PE Jr, Kupka RW, Grunze H, McElroy SL, Sugar CA, Suppes T. Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study. J Clin Psychiatry. 2009 Apr; 70: (4)450-7.
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Frye MA, Helleman G, McElroy SL, Altshuler LL, Black DO, Keck PE Jr, Nolen WA, Kupka R, Leverich GS, Grunze H, Mintz J, Post RM, Suppes T. Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression. Am J Psychiatry. 2009 Feb; 166 (2):164-72 Epub 2008 Nov 17
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Kupka R, Frye MA. Diagnosis and treatment of rapid cycling bipolar disorder. In: Yatham LN; Kusumakar V editor. Bipolar disorder: A clinician's guide to treatment management. 2nd Edition. New York: Routledge/Taylor & Francis Group; 2009. p. 45-77.
McKeon A, Frye MA, Delanty N. The alcohol withdrawal syndrome. J Neurol Neurosurg Psychiatry. 2008 Aug; 79: (8)854-62.
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Frye MA. Diagnostic dilemmas and clinical correlates of mixed states in bipolar disorder. J Clin Psychiatry. 2008 May; 69 (5):e13
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Shivakumar G, Bernstein IH, Suppes T, Stanley Foundation Bipolar Network, Keck PE, McElroy SL, Altshuler LL, Frye MA, Nolen WA, Kupka RW, Grunze H, Leverich GS, Mintz J, Post RM. Are bipolar mood symptoms affected by the phase of the menstrual cycle? J Womens Health (Larchmt). 2008 Apr; 17: (3)473-8.
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Cardenas J, Frye MA, Marusak SL, Levander EM, Chirichigno JW, Lewis S, Nakelsky S, Hwang S, Mintz J, Altshuler LL. Modal subcomponents of metabolic syndrome in patients with bipolar disorder. J Affect Disord. 2008 Feb; 106: (1-2)91-7.
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Post RM, Luckenbaugh DA, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J. Incidence of childhood-onset bipolar illness in the USA and Europe. Br J Psychiatry. 2008 Feb; 192: (2)150-1.
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Abulseoud OA, Hellmann G, Calabrese JR, Verduin ML, Chirichigno JW, McKowen J, Gitlin MJ, Altshuler LL, Frye MA. Sex and bipolar subtype association with self-reported hazardous alcohol consumption in bipolar depression. Journal of Dual Diagnosis. 2008; 4(3):291-302.
Goldberg JF, Bowden CL, Calabrese JR, Ketter TA, Dann RS, Frye MA, Suppes T, Post RM. Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder. Biol Psychiatry. 2008 Jan 01; 63: (1)125-30.
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Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, Fischer J, Chirichigno JW, Ventura J, Elman S, Tsuang J, Walot I, Thomas MA. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology. 2007 Dec; 32: (12)2490-9.
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Keck PE Jr, Frye MA, Thase ME. Bipolar depression: best practices for the hospitalized patient. CNS Spectr. 2007 Nov; 12(11 Suppl 19):1-13.
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Suppes T, Kelly DI, Keck PE Jr, McElroy SL, Altshuler LL, Mintz J, Frye MA, Nolen WA, Luckenbaugh DA, Post RM, Leverich GS, Kupka RW, Grunze H. Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network. Int Clin Psychopharmacol. 2007 Nov; 22: (6)376-81.
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Frye MA, Grunze H, Suppes T, McElroy SL, Keck PE Jr, Walden J, Leverich GS, Altshuler LL, Nakelsky S, Hwang S, Mintz J, Post RM. A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression. Am J Psychiatry. 2007 Aug; 164: (8)1242-9.
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McElroy SL, Suppes T, Frye MA, Altshuler LL, Stanford K, Martens B, Leverich GS, Post RM, Keck PE Jr. Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial. J Affect Disord. 2007 Aug; 101(1-3):275-81. Epub 2007 Jan 16.
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Levander E, Frye MA, McElroy S, Suppes T, Grunze H, Nolen WA, Kupka R, Keck PE Jr, Leverich GS, Altshuler LL, Hwang S, Mintz J, Post RM. Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism. J Affect Disord. 2007 Aug; 101: (1-3)211-7.
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McDermott BE, Quanbeck CD, Frye MA. Comorbid substance use disorder in women with bipolar disorder associated with criminal arrest. Bipolar Disord. 2007 Aug; 9: (5)536-40.
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Kupka RW, Altshuler LL, Nolen WA, Suppes T, Luckenbaugh DA, Leverich GS, Frye MA, Keck PE Jr, McElroy SL, Grunze H, Post RM. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord. 2007 Aug; 9: (5)531-5.
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McElroy SL, Frye MA, Altshuler LL, Suppes T, Hellemann G, Black D, Mintz J, Kupka R, Nolen W, Leverich GS, Denicoff KD, Post RM, Keck PE Jr. A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders. Bipolar Disord. 2007 Jun; 9(4):426-34.
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Abulseoud O, Sane N, Cozzolino A, Kiriakos L, Mehra V, Gitlin M, Masseling S, Whybrow P, Altshuler LL, Mintz J, Frye MA. Free T4 index and clinical outcome in patients with depression. J Affect Disord. 2007 Jun; 100(1-3):271-7. Epub 2006 Nov 22.
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Nolen WA, Kupka RW, Hellemann G, Frye MA, Altshuler LL, Leverich GS, Suppes T, Keck PE Jr, McElroy S, Grunze H, Mintz J, Post RM. Tranylcypromine vs. lamotrigine in the treatment of refractory bipolar depression: a failed but clinically useful study. Acta Psychiatr Scand. 2007 May; 115(5):360-5.
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Leverich GS, Post RM, Keck PE Jr, Altshuler LL, Frye MA, Kupka RW, Nolen WA, Suppes T, McElroy SL, Grunze H, Denicoff K, Moravec MK, Luckenbaugh D. The poor prognosis of childhood-onset bipolar disorder. J Pediatr. 2007 May; 150(5):485-90.
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Frye MA, Thomas MA, Yue K, Binesh N, Davanzo P, Ventura J, O'Neill J, Guze B, Curran JG, Mintz J. Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy. Psychiatry Res. 2007 Apr 15; 154: (3)259-65.
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Frye MA, Tsai GE, Huggins T, Coyle JT, Post RM. Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biol Psychiatry. 2007 Jan 15; 61(2):162-6. Epub 2006 Jun 02.
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Hirschfeld RM, Calabrese JR, Frye MA, Lavori PW, Sachs G, Thase ME, Wagner KD. Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and roughening. Psychopharmacol Bull. 2007; 40: (3)7-14.
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Fan AH, Frye MA, Masseling SJ, Hwang S, Cozzolino A, Kiriakos L, Mintz J, Sane N, Gitlin MJ, Altshuler L. Increased suicidality in mania complicated by alcoholism. Psychiatry. 2007; 4:34-9.
Frye MA, Thomas MA, Yue K, Binesh N, Davanzo P, Ventura J, O'Neil J, Barry Guze B, Curran JG, Mintz J. Reduced Basal Ganglia [NAA] and NAA/Cr in Mania: A 3T 1H MRS Study. J Psychiatric Research Neuroimaging. 2007; 154:259-65.
Post RM, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck PE Jr, Leverich GS, Kupka R, Nolen WA, Grunze H. New findings from the Bipolar Collaborative Network: clinical implications for therapeutics. Curr Psychiatry Rep. 2006 Dec; 8(6):489-97.
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Frye MA, Salloum IM. Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations. Bipolar Disord. 2006 Dec; 8: (6)677-85.
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Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry. 2006 Nov 1; 60(9):1020-2. Epub 2006 Jun 30.
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Frye MA, Yatham LN, Calabrese JR, Bowden CL, Ketter TA, Suppes T, Adams BE, Thompson TR. Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials. J Clin Psychiatry. 2006 Nov; 67: (11)1721-8.
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Altshuler LL, Post RM, Black DO, Keck PE Jr, Nolen WA, Frye MA, Suppes T, Grunze H, Kupka RW, Leverich GS, McElroy SL, Walden J, Mintz J. Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study. J Clin Psychiatry. 2006 Oct; 67(10):1551-60.
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Frye MA, Calabrese JR, Reed ML, Hirschfeld RM. Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study. CNS Spectr. 2006 Sep; 11(9):704-10; quiz 719.
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Brook M, Hilty DM, Liu W, Hu R, Frye MA. Discharge against medical advice from inpatient psychiatric treatment: a literature review. Psychiatr Serv. 2006 Aug; 57(8):1192-8.
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Post RM, Altshuler LL, Leverich GS, Frye MA, Nolen WA, Kupka RW, Suppes T, McElroy S, Keck PE, Denicoff KD, Grunze H, Walden J, Kitchen CM, Mintz J. Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. Br J Psychiatry. 2006 Aug; 189:124-31.
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Calabrese JR, Goldberg JF, Ketter TA, Suppes T, Frye M, White R, DeVeaugh-Geiss A, Thompson TR. Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies. Biol Psychiatry. 2006 Jun 1; 59(11):1061-4.
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Altshuler LL, Suppes T, Black DO, Nolen WA, Leverich G, Keck PE Jr, Frye MA, Kupka R, McElroy SL, Grunze H, Kitchen CM, Post R. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants. Am J Psychiatry. 2006 Feb; 163(2):313-5.
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Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Kupka RW, Denicoff KD, Nolen WA, Grunze H, Martinez MI, Post RM. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry. 2006 Feb; 163(2):232-9.
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Calabrese JR, Muzina DJ, Kemp DE, Sachs GS, Frye MA, Thompson TR, Klingman D, Reed ML, Hirschfeld RM. Predictors of bipolar disorder risk among patients currently treated for major depression. MedGenMed. 2006; 8(3):38. Epub 2006 Aug 15.
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Frye MA, Calabrese JR, Reed ML, Wagner KD, Lewis L, McNulty J, Hirschfeld RM. Use of health care services among persons who screen positive for bipolar disorder. Psychiatr Serv. 2005 Dec; 56(12):1529-33.
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Rasgon NL, Reynolds MF, Elman S, Saad M, Frye MA, Bauer M, Altshuler LL. Longitudinal evaluation of reproductive function in women treated for bipolar disorder. J Affect Disord. 2005 Dec; 89(1-3):217-25. Epub 2005 Sep 19.
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Quanbeck CD, McDermott BE, Frye MA. Clinical and legal characteristics of inmates with bipolar disorder. Curr Psychiatry Rep. 2005 Dec; 7(6):478-84.
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Suppes T, Mintz J, McElroy SL, Altshuler LL, Kupka RW, Frye MA, Keck PE Jr, Nolen WA, Leverich GS, Grunze H, Rush AJ, Post RM. Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon. Arch Gen Psychiatry. 2005 Oct; 62(10):1089-96.
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Quanbeck CD, Stone DC, McDermott BE, Boone K, Scott CL, Frye MA. Relationship between criminal arrest and community treatment history among patients with bipolar disorder. Psychiatr Serv. 2005 Jul; 56(7):847-52.
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Kupka RW, Luckenbaugh DA, Post RM, Suppes T, Altshuler LL, Keck PE Jr, Frye MA, Denicoff KD, Grunze H, Leverich GS, McElroy SL, Walden J, Nolen WA. Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients. Am J Psychiatry. 2005 Jul; 162(7):1273-80.
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Rasgon NL, Altshuler LL, Fairbanks L, Elman S, Bitran J, Labarca R, Saad M, Kupka R, Nolen WA, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Leverich G, Grunze H, Walden J, Post R, Mintz J. Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disord. 2005 Jun; 7(3):246-59.
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McElroy SL, Suppes T, Keck PE Jr, Black D, Frye MA, Altshuler LL, Nolen WA, Kupka RW, Leverich GS, Walden J, Grunze H, Post RM. Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial. J Clin Psychiatry. 2005 May; 66(5):617-24.
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Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL, Mandelkern MA, Bramen J, Voytek B, Woods R, Mazziotta JC, Whybrow PC. Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry. 2005 May; 10(5):456-69.
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Post RM, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Leverich GS, Kupka R, Nolen WA, Luckenbaugh DA, Walden J, Grunze H. Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder. J Clin Psychiatry. 2005 Mar; 66(3):370-4.
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Calabrese JR, Hirschfeld RM, Frye MA, Reed ML. Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample. J Clin Psychiatry. 2004 Nov; 65(11):1499-504.
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Gitlin M, Altshuler LL, Frye MA, Suri R, Huynh EL, Fairbanks L, Bauer M, Korenman S. Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors. J Psychiatry Neurosci. 2004 Sep; 29(5):383-6.
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State RC, Frye MA, Altshuler LL, Strober M, DeAntonio M, Hwang S, Mintz J. Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania. J Clin Psychiatry. 2004 Aug; 65(8):1057-63.
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Nolen WA, Luckenbaugh DA, Altshuler LL, Suppes T, McElroy SL, Frye MA, Kupka RW, Keck PE Jr, Leverich GS, Post RM. Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry. 2004 Aug; 161(8):1447-54.
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Quanbeck CD, Stone DC, Scott CL, McDermott BE, Altshuler LL, Frye MA. Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest. J Clin Psychiatry. 2004 Feb; 65(2):198-203.
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Frye MA, Gitlin MJ, Altshuler LL. Unmet needs in bipolar depression. Depress Anxiety. 2004; 19(4):199-208.
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Post RM, Leverich GS, Nolen WA, Kupka RW, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck P, Grunze H, Walden J, Stanley Foundation Bipolar Network. A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network. Bipolar Disord. 2003 Dec; 5(6):396-406.
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Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes TM, Keck PE Jr, McElroy SL, Kupka R, Nolen WA, Grunze H, Walden J. An overview of recent findings of the Stanley Foundation Bipolar Network (Part I). Bipolar Disord. 2003 Oct; 5(5):310-9.
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Keck PE Jr, McElroy SL, Havens JR, Altshuler LL, Nolen WA, Frye MA, Suppes T, Denicoff KD, Kupka R, Leverich GS, Rush AJ, Post RM. Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness. Compr Psychiatry. 2003 Jul-Aug; 44(4):263-9.
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Tohen M, Ketter TA, Zarate CA, Suppes T, Frye M, Altshuler L, Zajecka J, Schuh LM, Risser RC, Brown E, Baker RW. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry. 2003 Jul; 160(7):1263-71.
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Altshuler L, Suppes T, Black D, Nolen WA, Keck PE Jr, Frye MA, McElroy S, Kupka R, Grunze H, Walden J, Leverich G, Denicoff K, Luckenbaugh D, Post R. Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up. Am J Psychiatry. 2003 Jul; 160(7):1252-62.
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Quanbeck C, Frye M, Altshuler L. Mania and the law in California: understanding the criminalization of the mentally ill. Am J Psychiatry. 2003 Jul; 160(7):1245-50.
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Bertolino A, Frye M, Callicott JH, Mattay VS, Rakow R, Shelton-Repella J, Post R, Weinberger DR. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry. 2003 May 15; 53(10):906-13.
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Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE Jr, McElroy SL, Denicoff KD, Obrocea G, Nolen WA, Kupka R, Walden J, Grunze H, Perez S, Luckenbaugh DA, Post RM. Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network. J Clin Psychiatry. 2003 May; 64(5):506-15.
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Frye MA, Altshuler LL, McElroy SL, Suppes T, Keck PE, Denicoff K, Nolen WA, Kupka R, Leverich GS, Pollio C, Grunze H, Walden J, Post RM. Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder. Am J Psychiatry. 2003 May; 160(5):883-9.
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Altshuler LL, Frye MA, Gitlin MJ. Acceleration and augmentation strategies for treating bipolar depression. Biol Psychiatry. 2003 Apr 15; 53(8):691-700.
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Frye MA, Gitlin MJ, Altshuler LL. Treating acute mania. J Fam Pract. 2003 Mar; Suppl:S10-3.
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Frye MA, Pazzaglia PJ, George MS, Luckenbaugh DA, Vanderham E, Davis CL, Rubinow DR, Post RM. Low CSF somatostatin associated with response to nimodipine in patents with affective illness. Biol Psychiatry. 2003 Jan 15; 53(2):180-3.
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Hirschfeld RM, Calabrese JR, Weissman MM, Reed M, Davies MA, Frye MA, Keck PE Jr, Lewis L, McElroy SL, McNulty JP, Wagner KD. Screening for bipolar disorder in the community. J Clin Psychiatry. 2003 Jan; 64(1):53-9.
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Hirschfeld RM, Holzer C, Calabrese JR, Weissman M, Reed M, Davies M, Frye MA, Keck P, McElroy S, Lewis L, Tierce J, Wagner KD, Hazard E. Validity of the mood disorder questionnaire: a general population study. Am J Psychiatry. 2003 Jan; 160(1):178-80.
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Calabrese JR, Sullivan JR, Bowden CL, Suppes T, Goldberg JF, Sachs GS, Shelton MD, Goodwin FK, Frye MA, Kusumakar V. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry. 2002 Nov; 63(11):1012-9.
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Altshuler LL, Gitlin MJ, Mintz J, Leight KL, Frye MA. Subsyndromal depression is associated with functional impairment in patients with bipolar disorder. J Clin Psychiatry. 2002 Sep; 63(9):807-11.
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State RC, Altshuler LL, Frye MA. Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges. Am J Psychiatry. 2002 Jun; 159(6):918-25.
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Li X, Ketter TA, Frye MA. Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? J Affect Disord. 2002 May; 69(1-3):1-14.
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McElroy SL, Frye MA, Suppes T, Dhavale D, Keck PE Jr, Leverich GS, Altshuler L, Denicoff KD, Nolen WA, Kupka R, Grunze H, Walden J, Post RM. Correlates of overweight and obesity in 644 patients with bipolar disorder. J Clin Psychiatry. 2002 Mar; 63(3):207-13.
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Post RM, Altshuler LL, Frye MA, Suppes T, Rush AJ, Keck PE Jr, McElroy SL, Denicoff KD, Leverich GS, Kupka R, Nolen WA. Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers. Bipolar Disord. 2001 Oct; 3(5):259-65.
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Altshuler LL, Bauer M, Frye MA, Gitlin MJ, Mintz J, Szuba MP, Leight KL, Whybrow PC. Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature. Am J Psychiatry. 2001 Oct; 158(10):1617-22.
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Post RM, Nolen WA, Kupka RW, Denicoff KD, Leverich GS, Keck PE Jr, McElroy SL, Rush AJ, Suppes T, Altshuler LL, Frye MA, Grunze H, Walden J. The Stanley Foundation Bipolar Network. I. Rationale and methods. Br J Psychiatry Suppl. 2001 Jun; 41:s169-76.
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Kupka RW, Nolen WA, Altshuler LL, Denicoff KD, Frye MA, Leverich GS, Keck PE Jr, McElroy SL, Rush AJ, Suppes T, Post RM. The Stanley Foundation Bipolar Network. 2. Preliminary summary of demographics, course of illness and response to novel treatments. Br J Psychiatry Suppl. 2001 Jun; 41:s177-83.
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McElroy SL, Altshuler LL, Suppes T, Keck PE Jr, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001 Mar; 158(3):420-6.
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Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM, Osuch EA, Luckenbaugh DA, Cora-Ocatelli G, Leverich GS, Post RM. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol. 2000 Dec; 20(6):607-14.
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Post RM, Frye MA, Denicoff KD, Leverich GS, Dunn RT, Osuch EA, Speer AM, Obrocea G, Jajodia K. Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review. Bipolar Disord. 2000 Dec; 2(4):305-15.
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McElroy SL, Suppes T, Keck PE, Frye MA, Denicoff KD, Altshuler LL, Brown ES, Nolen WA, Kupka RW, Rochussen J, Leverich GS, Post RM. Open-label adjunctive topiramate in the treatment of bipolar disorders. Biol Psychiatry. 2000 Jun 15; 47(12):1025-33.
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Vawter MP, Frye MA, Hemperly JJ, VanderPutten DM, Usen N, Doherty P, Saffell JL, Issa F, Post RM, Wyatt RJ, Freed WJ. Elevated concentration of N-CAM VASE isoforms in schizophrenia. J Psychiatr Res. 2000 Jan-Feb; 34(1):25-34.
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Frye MA, Ketter TA, Leverich GS, Huggins T, Lantz C, Denicoff KD, Post RM. The increasing use of polypharmacotherapy for refractory mood disorders: 22 years of study. J Clin Psychiatry. 2000 Jan; 61(1):9-15.
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Frye MA, Denicoff KD, Bryan AL, Smith-Jackson EE, Ali SO, Luckenbaugh D, Leverich GS, Post RM. Association between lower serum free T4 and greater mood instability and depression in lithium-maintained bipolar patients. Am J Psychiatry. 1999 Dec; 156(12):1909-14.
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Altshuler LL, Keck PE Jr, McElroy SL, Suppes T, Brown ES, Denicoff K, Frye M, Gitlin M, Hwang S, Goodman R, Leverich G, Nolen W, Kupka R, Post R. Gabapentin in the acute treatment of refractory bipolar disorder. Bipolar Disord. 1999 Sep; 1(1):61-5.
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Goldstein TR, Frye MA, Denicoff KD, Smith-Jackson E, Leverich GS, Bryan AL, Ali SO, Post RM. Antidepressant discontinuation-related mania: critical prospective observation and theoretical implications in bipolar disorder. J Clin Psychiatry. 1999 Aug; 60(8):563-7; quiz 568-9.
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Ketter TA, Frye MA, Cora-Locatelli G, Kimbrell TA, Post RM. Metabolism and excretion of mood stabilizers and new anticonvulsants. Cell Mol Neurobiol. 1999 Aug; 19(4):511-32.
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Frye MA, Dunn RT, Gary KA, Kimbrell TA, Callahan AM, Luckenbaugh DA, Cora-Locatelli G, Vanderham E, Winokur A, Post RM. Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression. Biol Psychiatry. 1999 Apr 15; 45(8):1049-52.
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Little JT, Ketter TA, Mathe AA, Frye MA, Luckenbaugh D, Post RM. Venlafaxine but not bupropion decreases cerebrospinal fluid 5-hydroxyindoleacetic acid in unipolar depression. Biol Psychiatry. 1999 Feb 1; 45(3):285-9.
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Frye MA, Kimbrell TA, Dunn RT, Piscitelli S, Grothe D, Vanderham E, Cora-Locatelli G, Post RM, Ketter TA. Gabapentin does not alter single-dose lithium pharmacokinetics. J Clin Psychopharmacol. 1998 Dec; 18(6):461-4.
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Post RM, Denicoff KD, Frye MA, Dunn RT, Leverich GS, Osuch E, Speer A. A history of the use of anticonvulsants as mood stabilizers in the last two decades of the 20th century. Neuropsychobiology. 1998 Oct; 38(3):152-66.
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Pazzaglia PJ, Post RM, Ketter TA, Callahan AM, Marangell LB, Frye MA, George MS, Kimbrell TA, Leverich GS, Cora-Locatelli G, Luckenbaugh D. Nimodipine monotherapy and carbamazepine augmentation in patients with refractory recurrent affective illness. J Clin Psychopharmacol. 1998 Oct; 18(5):404-13.
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Post RM, Frye MA, Denicoff KD, Leverich GS, Kimbrell TA, Dunn RT. Beyond lithium in the treatment of bipolar illness. Neuropsychopharmacology. 1998 Sep; 19(3):206-19.
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McElroy SL, Frye M, Denicoff K, Altshuler L, Nolen W, Kupka R, Suppes T, Keck PE Jr, Leverich GS, Kmetz GF, Post RM. Olanzapine in treatment-resistant bipolar disorder. J Affect Disord. 1998 May; 49(2):119-22.
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Frye MA, Ketter TA, Altshuler LL, Denicoff K, Dunn RT, Kimbrell TA, Cora-Locatelli G, Post RM. Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. J Affect Disord. 1998 Mar; 48(2-3):91-104.
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Parekh PI, Ketter TA, Altshuler L, Frye MA, Callahan A, Marangell L, Post RM. Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients. Biol Psychiatry. 1998 Mar 1; 43(5):392-4.
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Bonds C, Frye MA, Coudreaut MF, Cunningham M, Spearing M, McGuire M, Guze B. Cost reduction with maintenance ECT in refractory bipolar disorder. J ECT. 1998 Mar; 14(1):36-41.
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Goldberg JF, Altshuler LL, Frye MA, Keck PE. The pharmacoeconomics of treating bipolar illness with divalproex sodium. Dir Psychiatry. 1998; 18:113-28.
Post RM, Kramlinger KG, Joffe RT, Roy-Byrne PP, Rosoff A, Frye MA, Huggins T. Rapid cycling bipolar affective disorder: lack of relation to hypothyroidism. Psychiatry Res. 1997 Aug 29; 72: (1)1-7.
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Callahan AM, Frye MA, Marangell LB, George MS, Ketter TA, L'Herrou T, Post RM. Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics. Biol Psychiatry. 1997 Feb 1; 41(3):264-72.
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Frye MA, Altshuler LL. Selection of initial treatment for bipolar disorder, manic phase. Mod Probl Pharmacopsychiatry. 1997; 25:88-113.
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Post RM, Denicoff KD, Frye MA, Leverich GS. Algorithms for bipolar mania. Mod Probl Pharmacopsychiatry. 1997; 25:114-45.
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Post RM, Leverich GS, Denicoff KD, Frye MA, Kimbrell TA, Dunn R. Alternative approaches to refractory depression in bipolar illness. Depress Anxiety. 1997; 5(4):175-89.
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Post RM, Denicoff KD, Leverich GS, Frye MA. Drug-induced switching in bipolar disorder: prevention and management. CNS Drugs. 1997; 8:352-65.
Post RM, Weiss SRR, Ketter TA, Denicoff KD, George MS, Frye MA, Leverich GR. The kindling model: implications for the etiology and treatment of mood disorders. Current Review Mood & Anxiety Disorders. 1997; 1:113-26.
Post RM, Ketter TA, Denicoff K, Pazzaglia PJ, Leverich GS, Marangell LB, Callahan AM, George MS, Frye MA. The place of anticonvulsant therapy in bipolar illness. Psychopharmacology (Berl). 1996 Nov; 128: (2)115-29.
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Poltorak M, Frye MA, Wright R, Hemperly JJ, George MS, Pazzaglia PJ, Jerrels SA, Post RM, Freed WJ. Increased neural cell adhesion molecule in the CSF of patients with mood disorder. J Neurochem. 1996 Apr; 66(4):1532-8.
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Frye MA, Altshuler LL, Szuba MP, Finch NN, Mintz J. The relationship between antimanic agent for treatment of classic or dysphoric mania and length of hospital stay. J Clin Psychiatry. 1996 Jan; 57(1):17-21.
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Post RM, Ketter TA, Pazzaglia PJ, Denicoff K, George MS, Callahan A, Leverich G, Frye M. Rational polypharmacy in the bipolar affective disorders. Epilepsy Res Suppl. 1996; 11:153-80.
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Post RM, Weiss SR, Smith M, Rosen J, Frye M. Stress, conditioning, and the temporal aspects of affective disorders. Ann N Y Acad Sci. 1995 Dec 29; 771:677-96.
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Frye MA, Coudreaut MF, Hakeman SM, Shah BG, Strouse TB, Skotzko CE. Continuous droperidol infusion for management of agitated delirium in an intensive care unit. Psychosomatics. 1995 May-Jun; 36(3):301-5.
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Coudreaut MF, Frye MA, Pynoos R. Civil unrest and exacerbation of psychiatric symptoms: a case series. J Nerv Ment Dis. 1995 Feb; 183(2):109-11.
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Frye MA, Melton LJ 3rd, Melton LJ 3rd, Bryant SC, Fitzpatrick LA, Wahner HW, Schwartz RS, Riggs BL, Riggs BL. Osteoporosis and calcification of the aorta. Bone Miner. 1992 Nov; 19 (2):185-94
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Melton LJ 3rd, Kan SH, Melton LJ 3rd, Frye MA, Wahner HW, O'Fallon WM, Riggs BL, Riggs BL. Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989 May; 129 (5):1000-11
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Mark A. Frye, M.D.

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