Translational Neuroimmunology: Charles L. Howe

Novel tools for neuroimmunological research

Primary mouse cortical neurons grown in polymeric microfluidic isolation devices permit the separation and independent manipulation of pure axons (right side). The neuron cell bodies (left side; nuclei in blue) extend long axons (green) through physical channels (center) that prohibit entry of cells. The axons enter a distal chamber that allows the lab to analyze axon physiology and pathophysiology. Axons frequently grow several millimeters long in this platform.