SUMMARY
The research interests of Kianoush B. Kashani, M.D., M.S., are in the fields of acute kidney injury (AKI), acid-base balance and electrolytes, renal replacement therapies, fluid management, point-of-care ultrasonography, and education. He has played a significant role in the discovery and validation of two new biomarkers of acute kidney injury (TIMP-2 and IGFBP7), defining the sarcopenia Index, and investigating ultrasound elastography, and he has created an electronic surveillance tool to detect AKI early in the intensive care unit (ICU). He provides lectures regarding AKI, education, and fluid management in the ICU across the globe. He has published many peer-reviewed papers and written several book chapters.
Focus areas
- Acute kidney injury prediction
- Development of early biomarkers of acute kidney injury
- Development of clinical and electronic models for prediction and prevention of acute kidney injury
- Acute kidney injury management
- Finding appropriate paths to manage acute kidney injury by:
- Implementing automated augmented human intelligence using artificial intelligence
- Finding appropriate paths to manage fluid and vasopressor therapy among patients who have a high risk of acute kidney injury
- Developing and validating clinical and automated models to assist clinicians in the management of nephrotoxins
- Fluid management
- Assessment of diuretic resistance among volume overloaded patients
- Development and validation of interventions for management of volume overload among patients with diuretic resistant volume overloaded
- Impact of different fluid types for resuscitation on patient outcomes
- Impact of different rates of fluid therapy and removal for resuscitation on clinical outcomes
- Electrolytes
- Development of new knowledge regarding the impact of electrolyte imbalances on patients with critical illnesses
- Innovation
- Real-time measurement and monitoring of kidney function
- Real-time measurement and monitoring of kidney hypoxia
- Noninvasive measurement of kidney intracapsular pressure
- Education
- Development and construct validity of education assessment tools
- Quality improvement project and its education
- Decrease burnout
Significance to patient care
The appropriate and timely identification of AKI in high-risk patients, the management of fluid and vasopressor therapy, and avoiding nephrotoxicity are steps that directly impact the quality of care provided to patients and will most likely impact clinical outcomes, including the need for dialysis, length of stay in the ICU and hospital, and mortality rates.