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Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Atrial Fibrillation
Rochester, MN
The purpose of this study is to compare edoxaban (investigational drug) with warfarin and enoxaparin, to see if it is safe and effective in preventing stroke and other blood clot complications in subjects with atrial fibrillation whose doctors plan to treat them with an electrical cardioversion. It is expected that 284 sites will recruit 2200 subjects from North America, EU, Russia, Ukraine and Israel. Participants will be randomly allocated to receive either treatment with edoxaban, or treatment with warfarin, plus enoxaparin if required. Participants will have an equal chance of receiving either treatment. Participants will be in the study for ...
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MediCool Protocol
Rochester, MN
The purpose of this study is to assess termination of atrial fibrillation (AF) following delivery of cold treatment to the oblique sinus using an experimental cooling module.
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A Study to Evaluate Potential Myocardial Injury Following Elective Direct Current Cardioversion
Rochester, MN
The purpose of this study is to prospectively determine if direct current cardioversion (DCCV) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT) assay.
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A Study to Analyze Arterial Stiffness and Atrial Fibrillation
Rochester, MN
The purpose of this study is to determine arterial stiffness in patients with atrial fibrillation (AF) using acoustic radiation vibrometry, to compare acoustic radiation force (ARF) measurements in patients with AF before and after electrical cardioversion, and to determine whether arterial stiffness predicts recurrence of AF after cardioversion.
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A Study to Analyze the Effect of Cardioversion on the Tricuspid and Mitral Valves in Patients with Atrial Fibrillation
Rochester, MN
The purpose of this study is to assess the immediate effect of cardioversion on both the tricuspid and mitral annular dynamics and size in patients with atrial fibrillation, and to compare the annular dynamics and dimensions in both the tricuspid and mitral valves immediately before and after cardioversion in patients with atrial fibrillation using 3D transesophageal echocardiography.
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Effect of Wearable Devices on Patient-Reported Outcomes and Clinical Utilization: A Randomized, Controlled Trial
Rochester, MN
The purpose of this study is to help researchers better understand the impact of wearable devices on patient experience and clinical trends following a cardioversion.
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Recovery of Left Ventricular Systolic Function and Atrial Fibrillation Recurrence after Restoration of Sinus Rhythm in Patients with Atrial Fibrillation
Rochester, MN
The objectives of this study are: (1) to analyze beat-to-beat variability and the variations of R-R interval to pre-preceding R-R interval (RRp/RRpp) ratio of left ventricular (LV) function by strain imaging (2D speckle tracking echocardiography) in patients with atrial fibrillation (AF) undergoing electrical cardioversion(ECV) or radiofrequency catheter ablation (RFCA) as a predictor of a recovery of LV function and volume after restoration of sinus rhythm , (2) to evaluate left atrial mechanics as a predictor of for AF recurrence after electrical cardioversion (ECV) or radiofrequency catheter ablation (RFCA)