Clinical Trials

A Study to Compare Two Ultrasound-based Methods for Assessing Diaphragm Muscle Function

Rochester, MN

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A Study to Compare Two Ultrasound-based Methods for Assessing Diaphragm Muscle Function

Location:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to assess and compare the utility of ultrasonographic shear wave elastography (SWE) method as compared to “ABCDE” thickening ratio and fraction method in assessing diaphragm function.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 19-006416
Sponsor Protocol Number:
19-006416

Ultrasound as Surrogate Diagnostic Tool for ACL Injury

Rochester, MN

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Ultrasound as Surrogate Diagnostic Tool for ACL Injury

Location:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

Aim 1 of this project will be entirely cadaveric and, thus, classified as not-human-subjects research by the Mayo Clinic IRB. Eight fresh-frozen cadaveric lower extremities (no history of knee trauma; < 50 years of age) will be acquired from a vendor that has provided >50 specimens with similar criteria in the past three years.5 Specimens will be thawed 24 hours prior to testing. 3D musculoskeletal (MSK) US images of the ACL in the intact knee will be acquired with an Aixplorer Mach 30 (SuperSonic Imagine, Bothell, WA). Literature described imaging techniques from both the anterior and posterior aspect of the knee will be used. SWE stiffness of the ACL will be calculated from the obtained images for cross-correlation against mechanical failure properties. Once images have been collected, each specimen will be resected such that the bone-ACL-bone complex remains intact. These complexes will be individually secured into custom mechanical fixtures and placed into a uniaxial hydraulic tensioner (MTS Systems, Eden Prairie, MN). Each structure will be exposed to 50 stress/relaxation cycles that vary ligament tension from 0-3% to remove viscoelastic effects. Specimens will then be tensioned at 20%/sec until failure is achieved. During tensioning, the hydraulic tensioner will measure displacement and a uniaxial load cell mounted to the tensioner will record linear force enacted on the tissue. ACL strain will be calculated as the linear displacement divided by the neutral ligament length (longest distance between ACL origin and insertion where the load cell registers 0 N force). Linear regression models will determine the significance of association between failure properties (ultimate strain, stress, and tensile strength) and US stiffness.

For Aim 2, 40 total lower extremities will be recruited for 3D US imaging of the ACL at their pre-surgical clinical visit. This will include the injured limb from 20 pre-surgical patients with an MRI-confirmed ACL rupture and 20 healthy control limbs with no documented history of injury or scheduled surgery. Subjects recruited for the injured limb cohort may be dual-recruited as controls so long as their contralateral limb satisfies the inclusion criteria. US images will be acquired from both the anterior and posterior aspect of each knee. Injured versus control status will be documented by the collecting research team member. These images will be assessed and descriptively categorized by a separate, blinded, experienced rater for tear presence, location, severity, and type. For injured limbs, the clinical MRI for each subject will be acquired and similarly categorized. For healthy limbs, a research MRI will be scheduled and similarly categorized. Chi-Square test of independence will be used to assess statistical correlation between the US and MRI image classification. Receiver operator curves will be used to assess sensitivity and specificity of US and MRI diagnoses of ACL injuries against known clinical conditions.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Contact us for the latest status	View complete study & contact information

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Site IRB:
- Rochester, Minnesota: 21-002175

A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma

Rochester, MN

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A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma

Location:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 15-002600
Sponsor Protocol Number:
15-002600

A Study Evaluating the Effectiveness of Ultrasound Imaging for Liver Steatosis Staging

Rochester, MN

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A Study Evaluating the Effectiveness of Ultrasound Imaging for Liver Steatosis Staging

Location:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to investigate the effectiveness of ultrasound imaging for staging liver steatosis, using liver fat content measured by MRI as the reference standard.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, Minn.	Open for enrollment	View complete study & contact information

Print study details

Site IRB:
- Rochester, Minnesota: 21-011918

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Search Results 21-24 of 24 for

A Study to Compare Two Ultrasound-based Methods for Assessing Diaphragm Muscle Function

Ultrasound as Surrogate Diagnostic Tool for ACL Injury

A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma

A Study Evaluating the Effectiveness of Ultrasound Imaging for Liver Steatosis Staging

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