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Clinical Studies

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  • Adjuvant De-escalation, Extracapsular Spread, P16, Transoral (A.D.E.P.T.) Trial for Oropharynx Malignancy (ADEPT) Scottsdale/Phoenix, Ariz. This randomized clinical trial studies the intensity of adjuvant ("helper") therapy required in p16 positive oropharynx cancer patients, who have had all known disease removed surgically by a minimally invasive approach, and who have extracapsular spread in their lymph nodes. After the surgery, patients are randomized to receive either radiation alone, or radiation and weekly cis-platinum during therapy. Patients are then followed for cancer, functional and quality of life outcomes.
  • Infrared In-Situ Imaging for Cancer Surgery Scottsdale/Phoenix, Ariz.

      The purpose of this study is to investigate the new mid-range infrared spectroscopy imaging technology as a non-invasive approach for detecting  cancer tumors from the surrounding tissues during surgery.
  • Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-Dose or Standard-Dose IMRT in Resectable p16 Locally Advanced Oropharynx Cancer Scottsdale/Phoenix, Ariz.

    This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy with chemotherapy may kill any tumor cells that remain after surgery. It is not yet known how much extra treatment needs to be given after surgery.
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