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Genetics of Pediatric Eye Disease

Overview

About this study

The purpose of this study is to test the hypothesis that abnormalities of binocular vision underlie the various forms of strabismus by determining the heritability of subclinical markers of abnormal binocular vision (same 6 as described in Aim 1 above) in family members of 150-200 patients (500 total subjects) with accommodative esotropia. This new knowledge will guide classification schemes for future genetic studies and provide insights into the underlying nature of strabismus.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Children of all ages diagnosed with accommodative esotropia who have at least one sibling 5 years or older that is available, along with their biological parents, for an evaluation in our department.
  • Strabismic patients with an underlying or associated developmental, neurologic, or ocular sensory disorder will be excluded. Patients whose biological parents or siblings are unavailable for evaluation will also be excluded.
  • At least one sibling will be required.

Exclusion Criteria: 

  • None 

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/16/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Brian Mohney, M.D.

Open for enrollment

Contact information:

Brian Mohney M.D.

(507) 284-3760

Mohney@mayo.edu

More information

Publications

Publications are currently not available

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