Citrullinated Antigens in Rheumatoid Arthritis Patient-Matched Synovial Biopsy, Synovial Fluid, and Serum Samples

Overview

About this study

The purpose of this study is to characterize the presence and level of SBT777101-reactive antigen in synovial biopsy tissue and fluid from both early and late-stage RA patients, who are on different type of medications (including but not limited to TNF-inhibitors. Correlate local levels of antigen with systemic levels measured in serum using matched patient tissue and blood sample, and correlate local and systemic levels of 7101-reactive antigen with ACPA, VICM, and other RA-related serum biomarkers. Also, to evaluate immune cell populations and correlating this with clinical information and levels of antigen.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Critieria:

Rheumatoid arthritis (RA) patients.
Age ≥ 18 and ≤ 70.
Body mass index (BMI) < 35 kg/m^2, inclusive.
Adults with adult-onset RA.
Moderate to severe disease activity defined by CDAI.
Inflamed joint available for synovial biopsy.

Exclusion Criteria:

< 18 years of age.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/6/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Fawad Aslam, M.B.B.S., M.S.	Open for enrollment	Contact information: Fawad Aslam M.B.B.S., M.S. Aslam.Fawad@mayo.edu

Mayo Clinic Location

Status

Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Fawad Aslam, M.B.B.S., M.S.

Open for enrollment

Contact information:

Fawad Aslam M.B.B.S., M.S.

Aslam.Fawad@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials