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Metabolic Agents Pharmacodynamic Analyses After Brain Radiation

Overview

About this study

Magnetic resonance spectroscopy is a feasible technique within brain tumor patients to detect metabolic differences between tumor and brain for metabolites indicative of the Warburg effect (lactate) and neural health (NAA and glutamate). Magnetic resonance spectroscopy is a feasible technique within brain tumor patients to detect metabolic differences between tumor and brain for metabolites indicative of the Warburg effect (lactate) and neural health (NAA and glutamate).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years
  • Radiographic evidence or histopathologic confirmation of CNS malignancy, with or without prior resection. 
  • Provide written informed consent for the current study.
  • Willing to undergo at least one MRI (at most two) with proton and/or phosphorus magnetic resonance spectroscopy analysis.

Exclusion Criteria: 

  • Vulnerable populations:  pregnant or nursing women (Arm B exempt), prisoners, mentally handicapped.
  • Cardiac pacemaker or artificial heart valve.
  • Metal plate, pin, or other metallic implant.
  • Intrauterine device, such as Copper-7 IUD.
  • Insulin or other drug pump.
  • Non-titanium aneurysm clips.
  • Previous gunshot wound.
  • Cochlear implant or other hearing device.
  • Employment history as a metalworker (had metal in eye).
  • Permanent (tattoo) eye-liner.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/16/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Terence Burns, M.D., Ph.D.

Contact us for the latest status

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

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CLS-20559107

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