Clinical Trials

Inclusion Criteria:

• Subjects will be recruited 1 year from their most recent live birth.
• 30 with Gestational Diabetes Mellitus (GDM) in the preceding pregnancy.
• 30 with no history of GDM.

Exclusion Criteria: 

• Individuals < 20 or > 40 years at the preceding pregnancy.
• Active systemic illness.
• Preceding multiple gestation pregnancy.
• Taking medication that affects glucose metabolism.
• Upper GI surgery that alters gastric emptying.
• Current BM I< 25kg/m^2.
• For the GDM group, those with GDM in any pregnancy prior to the most recent pregnancy will be excluded (to reduce within group heterogeneity).
• Currently pregnant or breastfeeding. At a screening visit, subjects will provide consent and undergo a history and physical. They will have an EKG, blood draw for complete blood count, fasting glucose, HbA1c and chemistry group, and a pregnancy test. Subjects will be excluded if HbA1c is > 5.6% or fasting glucose is > 100mg/dL. Body composition will be measured using dual-energy X-ray absorptiometry (iDXA scanner; GE Wauwatosa, WI).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/18/23. Questions regarding updates should be directed to the study team contact.