A Study of Effect of Megakaryocytes and Platelets in Breast Cancer

Overview

About this study

The purpose of this study is to determine how megakarocytes (cells in the bone marrow responsible for making platelets, which are necessary for blood clotting) affect the survivial and growth/division patterns of breast cancer stem cells, and the effects of breast cancer cells on megakatocyte survival and function. Through chart review, the study team will look at the relationship different blood components and different breast cancer diagnosis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Cohort 1-Biopsy negative

-Females age 18 and above

Cohort 2-Biopsy positive for carcinoma in situ (ductal, lobular, or other)

- Females age 18 and above

- Any subtype of breast cancer

Cohort 3-Biopsy positive for Stage 1, 2, or 3 invasive carcinoma (ductal, lobular, or
other)

- Females age 18 and above

- Any subtype of breast cancer

- Have no distant metastases

Cohort 4-Stage 4 Metastatic Disease

- Females age 18 and above

- Any subtype of breast cancer

Exclusion Criteria:

Cohort 1-Biopsy negative

- Males

- Females less than age 18

Cohort 2-Biopsy positive for carcinoma in situ (ductal, lobular, or other)

- Males

- Females less than age 18

- Currently undergoing neoadjuvant therapy

Cohort 3-Biopsy positive for Stage 1, 2, or 3 invasive carcinoma (ductal, lobular, or
other)

- Males

- Females less than age 18

- Presence of distant metastases

- Currently undergoing neoadjuvant therapy

Cohort 4-Stage 4 Metastatic Disease

- Males

- Females less than age 18

- Currently undergoing neoadjuvant therapy

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/10/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
La Crosse, Wis. Mayo Clinic principal investigator Scott Okuno, M.D.	Open for enrollment	Contact information: Leandra Pake CCRP (608) 392-9719 Franzen.Leandra@mayo.edu

Mayo Clinic Location

Status

Contact

La Crosse, Wis.

Mayo Clinic principal investigator

Scott Okuno, M.D.

Open for enrollment

Contact information:

Leandra Pake CCRP

(608) 392-9719

Franzen.Leandra@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials