Evaluation of a Pain Management Intervention Preparatory to a Future Pragmatic Trial, ASCENT Study

Overview

About this study

This clinical trial tests how well a pain management intervention preparatory to a future pragmatic trial works in rural dwelling and Hispanic cancer survivors. Cancer pain is a key case study in health disparities in the United States. Cancer pain is prevalent, under treated, and remains a major cause of suffering, impairment, and disability for millions of Americans. Individual pain interventions and care models show promise for cancer pain in controlled settings. Hispanic and rural-dwelling cancer survivors stand to benefit the most from electronic health record innovations, as each of these health disparities populations experience profound disparities in pain outcomes, including marked under- and over-prescribing of opioids. Additionally, Hispanics not only comprise a steadily growing proportion of cancer survivors, but are also increasingly immigrating to rural communities, potentially placing them at "double risk" for poor outcomes. This trial will allow for the refinement of pain management intervention components that could help the management of cancer-related pain in rural dwelling and Hispanic cancer survivors.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • A qualifying liquid or solid cancer diagnosis with visits at a participating Mayo site.
  • Age 18+.
  • NRS pain score of a 5+ out of 10.
  • Pain that developed (onset) or significantly worsened since cancer diagnosis.
  • Malignant Hematology including:
    • Lymphoma;
    • Myeloma;
    • Chronic Leukemias.

Exclusion Criteria:

  • PHQ8 score of 14 or more.
  • Life expectancy less than 12 months
  • Hospice enrollment
  • Admitted to hospital from Long Term Care/SNF
  • Acute Leukemias
  • Primary brain tumors
  • Confinement to a bed or a chair more than a third of waking hours because of health complications.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/30/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Andrea Cheville, M.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Jessica Austin, Ph.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available
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CLS-20549841

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