Impact of Temperature-sensitive Radiofrequency Ablation in Patients with Malignant Biliary Obstructions Undergoing Biliary Stenting

Overview

About this study

The purpose of this study is to assess the impact of temperature-sensitive radiofrequency ablation (RFA) immediately before biliary stent placement on duration of biliary stent patency and re-intervention free survival. Additionally, to describe the incidence of adverse events with combination RFA plus stenting.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- Malignant biliary stricture

- Biopsy-confirmed pancreaticobiliary or ampullary malignancy that have agreed to
undergo radiofrequency ablation with placement of biliary stents

- Patients with life expectancy greater than 3 months

Exclusion Criteria:

- Patients who are pregnant, have cirrhosis, or significant liver metastasis >30% on
radiologic imaging suggestive of poor liver function that will not improve despite
endoscopic drainage.

- Patients who have undergone prior biliary decompression stents or percutaneous
drainage that cannot be removed at time of ERCP and thus preclude effective
radiofrequency ablation

- Patients with altered anatomy unable to undergo conventional ERCP

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 5/4/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Vinay Chandrasekhara, M.D.	Open for enrollment	Contact information: Lillian Wang M.D. Wang.Lillian@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Vinay Chandrasekhara, M.D.

Open for enrollment

Contact information:

Lillian Wang M.D.

Wang.Lillian@mayo.edu

More information

Publications

Publications are currently not available

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